dentate gyrus of hippocampal formation granule cell
superior frontal gyrus
primary visual cortex
hippocampus proper
Region I of hippocampus proper
nucleus accumbens
prefrontal cortex
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
integrin binding
protein binding
Cellular component
integral component of membrane
plasma membrane
integral component of plasma membrane
membrane
Biological process
cell adhesion
phagocytosis
regulation of immune response
extracellular matrix organization
cell-cell adhesion
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
7087
15898
Ensembl
ENSG00000105376
ENSMUSG00000032174
UniProt
Q9UMF0
Q60625
RefSeq (mRNA)
NM_003259
NM_008319
RefSeq (protein)
NP_003250
NP_032345
Location (UCSC)
Chr 19: 10.29 – 10.3 Mb
Chr 9: 20.94 – 20.95 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Intercellular adhesion molecule 5 is a protein that in humans is encoded by the ICAM5 gene.[5][6][7]
The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is expressed on the surface of telencephalic neurons and displays two types of adhesion activity, homophilic binding between neurons and heterophilic binding between neurons and leukocytes. It may be a critical component in neuron-microglial cell interactions in the course of normal development or as part of neurodegenerative diseases.[7]
^ abcGRCh38: Ensembl release 89: ENSG00000105376 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000032174 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Mizuno T, Yoshihara Y, Inazawa J, Kagamiyama H, Mori K (Feb 1997). "cDNA cloning and chromosomal localization of the human telencephalin and its distinctive interaction with lymphocyte function-associated antigen-1". J Biol Chem. 272 (2): 1156–63. doi:10.1074/jbc.272.2.1156. PMID 8995416.
^Kilgannon P, Turner T, Meyer J, Wisdom W, Gallatin WM (Jan 1999). "Mapping of the ICAM-5 (telencephalin) gene, a neuronal member of the ICAM family, to a location between ICAM-1 and ICAM-3 on human chromosome 19p13.2". Genomics. 54 (2): 328–30. doi:10.1006/geno.1998.5565. PMID 9828136.
Intercellular adhesion molecule 5 is a protein that in humans is encoded by the ICAM5 gene. The protein encoded by this gene is a member of the intercellular...