CD31 information

PECAM1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2KY5, 5C14
Identifiers
Aliases	PECAM1, CD31, CD31/EndoCAM, GPIIA', PECA1, PECAM-1, endoCAM, platelet and endothelial cell adhesion molecule 1, PCAM-1
External IDs	OMIM: 173445 MGI: 97537 HomoloGene: 47925 GeneCards: PECAM1
Gene location (Human)
Chr.	Chromosome 17 (human)
End	64,413,776 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	106,641,454 bp
RNA expression pattern
	Top expressed in
	visceral pleura; ; lower lobe of lung; ; pericardium; ; right lung; ; parietal pleura; ; monocyte; ; upper lobe of lung; ; upper lobe of left lung; ; Achilles tendon; ; bone marrow cells;
	Top expressed in
	right lung lobe; ; left lung; ; left lung lobe; ; ascending aorta; ; aortic valve; ; glomerular capillary; ; digastric muscle; ; dermis; ; body of femur; ; soleus muscle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; protein homodimerization activity;
Cellular component	integral component of membrane; platelet alpha granule membrane; membrane raft; cell junction; plasma membrane; extracellular exosome; membrane; extracellular space; secretory granule membrane; cytoplasm; external side of plasma membrane; smooth muscle contractile fiber; cell-cell contact zone; cell periphery;
Biological process	diapedesis; glomerular endothelium development; platelet degranulation; cell adhesion; extracellular matrix organization; cell recognition; leukocyte migration; signal transduction; phagocytosis; neutrophil degranulation; leukocyte cell-cell adhesion; neutrophil extravasation; cell-cell adhesion via plasma-membrane adhesion molecules; angiogenesis; endothelial cell morphogenesis; homophilic cell adhesion via plasma membrane adhesion molecules; Rho protein signal transduction; regulation of cell migration; monocyte extravasation; wound healing; positive regulation of tyrosine phosphorylation of STAT protein; endothelial cell migration; endothelial cell-matrix adhesion;
	Sources:Amigo / QuickGO
Orthologs
	5175
	18613
	ENSG00000261371
	ENSMUSG00000020717
	P16284
	Q08481
	NM_000442
	NM_001032378; NM_008816; NM_001305157; NM_001305158
	NP_000433
	NP_001027550; NP_001292086; NP_001292087; NP_032842
	Wikidata
View/Edit Human	View/Edit Mouse

Platelet endothelial cell adhesion molecule (PECAM-1) also known as cluster of differentiation 31 (CD31) is a protein that in humans is encoded by the PECAM1 gene found on chromosome17q23.3.^[5]^[6]^[7]^[8] PECAM-1 plays a key role in removing aged neutrophils from the body.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000261371 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020717 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Cite error: The named reference entrez was invoked but never defined (see the help page).
^ Newman PJ, Berndt MC, Gorski J, White GC, Lyman S, Paddock C, Muller WA (March 1990). "PECAM-1 (CD31) cloning and relation to adhesion molecules of the immunoglobulin gene superfamily". Science. 247 (4947): 1219–1222. Bibcode:1990Sci...247.1219N. doi:10.1126/science.1690453. PMID 1690453.
^ Gumina RJ, Kirschbaum NE, Rao PN, vanTuinen P, Newman PJ (June 1996). "The human PECAM1 gene maps to 17q23". Genomics. 34 (2): 229–232. doi:10.1006/geno.1996.0272. PMID 8661055.
^ Xie Y, Muller WA (October 1996). "Fluorescence in situ hybridization mapping of the mouse platelet endothelial cell adhesion molecule-1 (PECAM1) to mouse chromosome 6, region F3-G1". Genomics. 37 (2): 226–228. doi:10.1006/geno.1996.0546. PMID 8921400.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000261371 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020717 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] Cite error: The named reference entrez was invoked but never defined (see the help page).

[pmid1690453-6] Newman PJ, Berndt MC, Gorski J, White GC, Lyman S, Paddock C, Muller WA (March 1990). "PECAM-1 (CD31) cloning and relation to adhesion molecules of the immunoglobulin gene superfamily". Science. 247 (4947): 1219–1222. Bibcode:1990Sci...247.1219N. doi:10.1126/science.1690453. PMID 1690453.

[pmid8661055-7] Gumina RJ, Kirschbaum NE, Rao PN, vanTuinen P, Newman PJ (June 1996). "The human PECAM1 gene maps to 17q23". Genomics. 34 (2): 229–232. doi:10.1006/geno.1996.0272. PMID 8661055.

[pmid8921400-8] Xie Y, Muller WA (October 1996). "Fluorescence in situ hybridization mapping of the mouse platelet endothelial cell adhesion molecule-1 (PECAM1) to mouse chromosome 6, region F3-G1". Genomics. 37 (2): 226–228. doi:10.1006/geno.1996.0546. PMID 8921400.

CD31 information

and 23 Related for: CD31 information

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