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Lifitegrast information


Lifitegrast
Clinical data
Trade namesXiidra
Other namesSAR-1118
AHFS/Drugs.comMonograph
MedlinePlusa616039
Pregnancy
category
  • AU: B1
Routes of
administration
Eye drops
ATC code
  • S01XA25 (WHO)
Legal status
Legal status
  • AU: S4 (Prescription only)
  • CA: ℞-only[1]
  • US: ℞-only
Identifiers
IUPAC name
  • N-{[2-(1-Benzofuran-6-ylcarbonyl)-5,7-dichloro-1,2,3,4-tetrahydro-6-isoquinolinyl]carbonyl}-3-(methylsulfonyl)-L-phenylalanine
CAS Number
  • 1025967-78-5
PubChem CID
  • 11965427
ChemSpider
  • 10139520
UNII
  • 038E5L962W
KEGG
  • D10374
ChEBI
  • CHEBI:133023 checkY
ChEMBL
  • ChEMBL2048028
CompTox Dashboard (EPA)
  • DTXSID60145345 Edit this at Wikidata
ECHA InfoCard100.245.695 Edit this at Wikidata
Chemical and physical data
FormulaC29H24Cl2N2O7S
Molar mass615.48 g·mol−1
3D model (JSmol)
  • Interactive image
SMILES
  • CS(=O)(=O)c1cccc(c1)C[C@@H](C(=O)O)NC(=O)c2c(cc3c(c2Cl)CCN(C3)C(=O)c4ccc5ccoc5c4)Cl
InChI
  • InChI=1S/C29H24Cl2N2O7S/c1-41(38,39)20-4-2-3-16(11-20)12-23(29(36)37)32-27(34)25-22(30)13-19-15-33(9-7-21(19)26(25)31)28(35)18-6-5-17-8-10-40-24(17)14-18/h2-6,8,10-11,13-14,23H,7,9,12,15H2,1H3,(H,32,34)(H,36,37)/t23-/m0/s1
  • Key:JFOZKMSJYSPYLN-QHCPKHFHSA-N

Lifitegrast, sold under the brand name Xiidra (/ˈzdrə/[2]), is a medication for the treatment of signs and symptoms of dry eye, a syndrome called keratoconjunctivitis sicca. Lifitegrast reduces inflammation by inhibiting inflammatory cell binding.[3] It is often used in conjunction with ciclosporin (Ikervis, Restasis, or Cequa) for dry eye treatment including meibomian gland dysfunction and inflammatory dry eye.

  1. ^ "Eye health". Health Canada. 9 May 2018. Retrieved 13 April 2024.
  2. ^ "Patient information: Xiidra® (ZYE-druh) (lifitegrast ophthalmic solution) 5% for topical ophthalmic use" (PDF). Novartis. June 2020. Retrieved 5 February 2021.
  3. ^ Cite error: The named reference Tauber was invoked but never defined (see the help page).

and 6 Related for: Lifitegrast information

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Lifitegrast

Last Update:

Lifitegrast, sold under the brand name Xiidra (/ˈzaɪdrə/), is a medication for the treatment of signs and symptoms of dry eye, a syndrome called keratoconjunctivitis...

Word Count : 575

Meibomian gland

Last Update:

shampoo, or emptying ("expression") of the gland by a professional. Lifitegrast and Restasis are topical medication commonly used to control the inflammation...

Word Count : 1183

Meibomian gland dysfunction

Last Update:

cleanser, or emptying ("expression") of the gland by a professional. Lifitegrast and Restasis are topical medication commonly used to control the inflammation...

Word Count : 817

ATC code S01

Last Update:

Mercaptamine S01XA22 Ocriplasmin S01XA23 Sirolimus S01XA24 Cenegermin S01XA25 Lifitegrast S01XA26 Riboflavin S01XA27 Voretigene neparvovec S01XA28 Varenicline...

Word Count : 800

Dry eye syndrome

Last Update:

conjunctiva, rather than by directly stimulating the lacrimal glands. Lifitegrast was approved by the US FDA for the treatment of the condition in 2016...

Word Count : 6282

Signaling peptide receptor

Last Update:

Secretin Thymopoietin Thymosins Thymulin Urotensin-II VGF Exogenous Lifitegrast (LFA-1 antagonist) Neuropeptide receptor Neurotransmitter receptor Peptide+receptor...

Word Count : 706

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