Integrin alpha L information

ITGAL
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4IXD, 1CQP, 1DGQ, 1LFA, 1MJN, 1MQ8, 1MQ9, 1MQA, 1RD4, 1T0P, 1XDD, 1XDG, 1XUO, 1ZON, 1ZOO, 1ZOP, 2ICA, 2K8O, 2M3E, 2O7N, 3BN3, 3BQM, 3BQN, 3E2M, 3EOA, 3EOB, 3F74, 3F78, 3HI6, 3M6F, 3TCX, 5E6S, 5E6R, 5E6U
Identifiers
Aliases	ITGAL, CD11A, LFA-1, LFA1A, integrin subunit alpha L
External IDs	OMIM: 153370; MGI: 96606; HomoloGene: 1666; GeneCards: ITGAL; OMA:ITGAL - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	30,523,567 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	126,934,310 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; monocyte; ; blood; ; spleen; ; lymph node; ; bone marrow cells; ; appendix; ; thymus; ; upper lobe of left lung; ; epithelium of colon;
	Top expressed in
	granulocyte; ; thymus; ; mesenteric lymph nodes; ; blood; ; spleen; ; subcutaneous adipose tissue; ; submandibular gland; ; bone marrow; ; right lung lobe; ; stroma of bone marrow;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein-containing complex binding; metal ion binding; protein binding; protein heterodimerization activity; ICAM-3 receptor activity; cell adhesion molecule binding;
Cellular component	integral component of membrane; integrin alphaL-beta2 complex; membrane; cell surface; integrin complex; extracellular exosome; plasma membrane; specific granule membrane;
Biological process	leukocyte cell-cell adhesion; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell; extracellular matrix organization; receptor clustering; cell adhesion; regulation of immune response; integrin-mediated signaling pathway; cell-matrix adhesion; inflammatory response; leukocyte migration; signal transduction; phagocytosis; neutrophil degranulation; cell-cell adhesion;
	Sources:Amigo / QuickGO
Orthologs
	3683
	16408
	ENSG00000005844
	ENSMUSG00000030830
	P20701
	P24063
	NM_001114380; NM_002209
	NM_001253872; NM_001253873; NM_001253874; NM_008400
	NP_001107852; NP_002200
	NP_001240801; NP_001240802; NP_001240803; NP_032426
	Wikidata
View/Edit Human	View/Edit Mouse

Integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide), also known as ITGAL, is a protein that in humans is encoded by the ITGAL gene.^[5] CD11a functions in the immune system. It is involved in cellular adhesion and costimulatory signaling. It is the target of the drug efalizumab.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000005844 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030830 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "NCBI".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000005844 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030830 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] "NCBI".

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