heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
extracellular matrix organization
receptor clustering
cell adhesion
regulation of immune response
integrin-mediated signaling pathway
cell-matrix adhesion
inflammatory response
leukocyte migration
signal transduction
phagocytosis
neutrophil degranulation
cell-cell adhesion
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
3683
16408
Ensembl
ENSG00000005844
ENSMUSG00000030830
UniProt
P20701
P24063
RefSeq (mRNA)
NM_001114380 NM_002209
NM_001253872 NM_001253873 NM_001253874 NM_008400
RefSeq (protein)
NP_001107852 NP_002200
NP_001240801 NP_001240802 NP_001240803 NP_032426
Location (UCSC)
Chr 16: 30.47 – 30.52 Mb
Chr 7: 126.9 – 126.93 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide), also known as ITGAL, is a protein that in humans is encoded by the ITGAL gene.[5] CD11a functions in the immune system. It is involved in cellular adhesion and costimulatory signaling. It is the target of the drug efalizumab.
^ abcGRCh38: Ensembl release 89: ENSG00000005844 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000030830 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Integrin, alphaL (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide), also known as ITGAL, is a protein that in humans...
Integrinalpha M (ITGAM) is one protein subunit that forms heterodimeric integrinalpha-M beta-2 (αMβ2) molecule, also known as macrophage-1 antigen (Mac-1)...
Integrins are transmembrane receptors that help cell-cell and cell-extracellular matrix (ECM) adhesion. Upon ligand binding, integrins activate signal...
known as Integrin, alpha X (complement component 3 receptor 4 subunit) (ITGAX), is a gene that encodes for CD11c . CD11c is an integrinalpha X chain protein...
is an integrinalpha subunit. It makes up half of the α4β1 lymphocyte homing receptor. The product of this gene belongs to the integrinalpha chain family...
CD49b gene. The CD49b protein is an integrinalpha subunit. It makes up half of the α2β1 integrin duplex. Integrins are heterodimeric integral membrane...
Integrinalpha-V is a protein that in humans is encoded by the ITGAV gene. ITGAV encodes integrinalpha chain V. Integrins are heterodimeric integral membrane...
Alpha-7 integrin is a protein that in humans is encoded by the ITGA7 gene. Alpha-7 integrin is critical for modulating cell-matrix interactions. Alpha-7...
Integrinalpha-5 is a protein that in humans is encoded by the ITGA5 gene. The product of this gene belongs to the integrinalpha chain family. Integrins...
Integrinalpha-IIb is a protein that in humans is encoded by the ITGA2B gene. ITGA2B, also known as CD41, encodes integrinalpha chain 2b. Integrins are...
with integrinalpha 1 and integrinalpha 2 to form integrin complexes which function as collagen receptors. It also forms dimers with integrinalpha 3 to...
CD18 (Integrin beta chain-2) is an integrin beta chain protein that is encoded by the ITGB2 gene in humans. Upon binding with one of a number of alpha chains...
Integrinalpha-6 is a protein that in humans is encoded by the ITGA6 gene. The ITGA6 protein product is the integrinalpha chain alpha 6. Integrins are...
Integrinalpha-9 is a protein that in humans is encoded by the ITGA9 gene. Cytogenetic location: 3p22.2 This gene encodes an alphaintegrin. Integrins...
Integrinalpha-10 also known as ITGA10 is a protein that in humans is encoded by the ITGA10 gene. Integrins are integral membrane proteins composed of...
Integrin, beta 4 (ITGB4) also known as CD104 (Cluster of Differentiation 104), is a human gene. Integrins are heterodimers composed of alpha and beta subunits...
Integrinalpha-D is a protein that in humans is encoded by the ITGAD gene. GRCh38: Ensembl release 89: ENSG00000156886 – Ensembl, May 2017 GRCm38: Ensembl...
survival, and transcription. Integrins are heterodimeric, as they consist of an alpha and beta subunit. There are currently 18 alpha subunits and 8 beta subunits...
ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given...
Integrin beta-7 is an integrin protein that in humans is encoded by the ITGB7 gene. It can pair with ITGA4 (CD49d) to form the heterodimeric integrin...
to integrin α4β7 (LPAM-1, lymphocyte Peyer's patch adhesion molecule 1, a dimer of Integrinalpha-4 and Integrin beta-7), blocking the α4β7 integrin results...
Integrin beta-6 is a protein that in humans is encoded by the ITGB6 gene. It is the β6 subunit of the integrin αvβ6. Integrins are αβ heterodimeric glycoproteins...
Global Information
