High affinity copper uptake protein 1 (CTR1) is a protein that in humans is encoded by the SLC31A1 gene.[5][6]
Copper is an element essential for life, but excessive copper can be toxic or even lethal to the cell. Therefore, cells have developed sophisticated ways to maintain a critical copper balance, with the intake, export, and intracellular compartmentalization or buffering of copper strictly regulated. The 2 related genes ATP7A and ATP7B, responsible for the human diseases Menkes syndrome and Wilson disease, respectively, are involved in copper export. In S. cerevisiae, the copper uptake genes CTR1, CTR2, and CTR3 have been identified, and in human the CTR1 and CTR2 (MIM 603088) genes have been identified.[6]
^ abcGRCh38: Ensembl release 89: ENSG00000136868 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000066150 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Zhou B, Gitschier J (Aug 1997). "hCTR1: a human gene for copper uptake identified by complementation in yeast". Proc Natl Acad Sci U S A. 94 (14): 7481–6. Bibcode:1997PNAS...94.7481Z. doi:10.1073/pnas.94.14.7481. PMC 23847. PMID 9207117.
^ ab"Entrez Gene: SLC31A1 solute carrier family 31 (copper transporters), member 1".
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