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Siderophore information


Structure of the siderophore triacetylfusarinine encapsulating iron(III) within a tris(hydroxamate) coordination sphere (color code: red = oxygen, gray = carbon, blue = nitrogen, dark blue = iron).[1]

Siderophores (Greek: "iron carrier") are small, high-affinity iron-chelating compounds that are secreted by microorganisms such as bacteria and fungi. They help the organism accumulate iron.[2][3][4][5] Although a widening range of siderophore functions is now being appreciated,[6] siderophores are among the strongest (highest affinity) Fe3+ binding agents known. Phytosiderophores are siderophores produced by plants.

  1. ^ Hossain MB, Eng-Wilmot DL, Loghry RA, an der Helm D (1980). "Circular Dichroism, Crystal Structure, and Absolute Configuration of the Siderophore Ferric N,N',N"-Triacetylfusarinine, FeC39H57N6O15". Journal of the American Chemical Society. 102 (18): 5766–5773. doi:10.1021/ja00538a012.
  2. ^ Neilands JB (November 1995). "Siderophores: structure and function of microbial iron transport compounds". The Journal of Biological Chemistry. 270 (45): 26723–6. doi:10.1074/jbc.270.45.26723. PMID 7592901.
  3. ^ Hider RC, Kong X (May 2010). "Chemistry and biology of siderophores". Natural Product Reports. 27 (5): 637–57. doi:10.1039/b906679a. PMID 20376388. S2CID 36973725.
  4. ^ Crosa JH, Mey AR, Payne SM, eds. (2004). Iron Transport in Bacteria. ASM Press. ISBN 978-1-55581-292-8.
  5. ^ Cornelis P, Andrews SC, eds. (2010). Iron Uptake and Homeostasis in Microorganisms. Caister Academic Press. ISBN 978-1-904455-65-3.
  6. ^ Johnstone TC, Nolan EM (April 2015). "Beyond iron: non-classical biological functions of bacterial siderophores". Dalton Transactions. 44 (14): 6320–39. doi:10.1039/C4DT03559C. PMC 4375017. PMID 25764171.

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Siderophore

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the siderophore biosynthesis pathway, proved siderophore-mediated iron uptake to be essential for virulence. Mutation of the downstream siderophore biosynthesis...

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cephalosporins, cephalosporin-beta-lactamase-inhibitor combinations, and new siderophore cephalosporins. Ceftazidime (3rd generation) Cefepime (4th generation)...

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Cefiderocol

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side chain further enhances its β-lactamase stability and renders it a siderophore. This means it enters into bacterial cells by binding to iron, which...

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a cyclic hexa-peptide that forms a complex with iron atoms. It is a siderophore composed of three glycine and three modified ornithine residues with...

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Pseudomonas aeruginosa

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of iron, P. aeruginosa uses siderophores, which are secreted molecules that bind and transport iron. These iron-siderophore complexes, however, are not...

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Parasites of phytoplankton

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vinelandii Siderophore Scenedesmus sp. A. vinelandii Siderophore Accumulation of fatty acids and lipids C. vulgaris A. brasilense Siderophore mediated nitrogen...

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although the risk is lower than with penicillins.[citation needed] Siderophore-conjugated monobactams show promise for the treatment of multi drug-resistant...

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Bacillus anthracis

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It feeds on the heme of blood protein haemoglobin using two secretory siderophore proteins, IsdX1 and IsdX2. Untreated B. anthracis infection is usually...

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biohybrid Lines on the Antiquity of Microbes Microbially induced sedimentary structure Omics Physical factors affecting microbial life Siderophore Category...

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bis-catechol siderophore found in M. hydrocarbonoclasticus, A. macleodii, and the anthrax-producing B. anthracis. Like other siderophores petrobactin is...

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and qualitative information on molecules of interest like aluminum and siderophores. Qualitatively a color change can be observed while also allowing to...

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A colorless solid, it is a siderophore. More specifically, it is a phytosiderophore, i.e. a plant-produced siderophore. It functions as an iron accumulating...

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combination (cell wall synthesis inhibitor). Cefiderocol: cephalosporin siderophore. FDA approved on 14 November 2019. Imipenem/relebactam: carbapenem/ β-lactamase...

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Pseudomonas

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fluorescent yellow-green siderophore under iron-limiting conditions. Certain Pseudomonas species may also produce additional types of siderophore, such as pyocyanin...

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Iron

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bacteria have evolved very high-affinity sequestering agents called siderophores. After uptake in human cells, iron storage is precisely regulated. A...

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Siderocalin

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that can prevent iron acquisition by pathogenic bacteria by binding siderophores, which are iron-binding chelators made by microorganisms. Iron serves...

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Pathogenic bacteria

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called siderophores, which take the iron away from iron-transport proteins by binding to the iron even more tightly. Once the iron-siderophore complex...

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Mold

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nutrients throughout ecosystems. Many molds also synthesize mycotoxins and siderophores which, together with lytic enzymes, inhibit the growth of competing microorganisms...

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Chelation

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produce water-soluble pigments that serve as chelating agents, termed siderophores. For example, species of Pseudomonas are known to secrete pyochelin and...

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Pathogen

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cells, capsules to prevent opsonization and phagocytosis, toxins, and siderophores to acquire iron. The bacterial disease tuberculosis, primarily caused...

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Mycobactin

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Mycobactin is a siderophore used by members of the genus Mycobacterium to shuttle free extracellular iron ions into the cytoplasm of mycobacterial cells...

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compounds such as siderophores are often secreted into the soil by fungi and bacteria to aid in the acquisition of these cations. A siderophore is a small molecule...

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Pyoverdine

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(alternatively, and less commonly, spelled as pyoverdins) are fluorescent siderophores produced by certain pseudomonads. Pyoverdines are important virulence...

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Stenotrophomonas

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they produce the siderophore enterobactin and many TonB‑dependent receptors (TBDRs) used for the active transport of iron–siderophore complexes. Parte...

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Elizabeth Nolan

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awarded a Fulbright Program Scholarship and moved to France to study siderophore-iron complexes. Nolan moved to Massachusetts Institute of Technology...

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Ferric

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grasses can thrive in such environments by secreting compounds called siderophores that form soluble complexes with iron(III), that can be reabsorbed into...

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