Diagram showing a generalized view of cellular iron homeostasis in humans. Iron import can occur via endocytosis of transferrin receptor 1 or via ferrous iron importers DMT1 and ZIP14, which require the activity of iron reductases such as STEAP2, SDR-2 and Dcytb. Intracellular iron can be stored in ferritin and used for protein biosynthesis, or to generate reactive oxygen species (ROS) and regulate transcription via iron-responsive element-binding proteins (IRP1/2). Export occurs through ferroportin, often aided by hephaestin (Hp) and/or ceruloplasmin (Cp), and repressed by hepcidin.
Human iron metabolism is the set of chemical reactions that maintain human homeostasis of iron at the systemic and cellular level. Iron is both necessary to the body and potentially toxic. Controlling iron levels in the body is a critically important part of many aspects of human health and disease. Hematologists have been especially interested in systemic iron metabolism, because iron is essential for red blood cells, where most of the human body's iron is contained. Understanding iron metabolism is also important for understanding diseases of iron overload, such as hereditary hemochromatosis, and iron deficiency, such as iron-deficiency anemia.
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Humanironmetabolism is the set of chemical reactions that maintain human homeostasis of iron at the systemic and cellular level. Iron is both necessary...
Ironmetabolism disorders may involve a number of genes including HFE and TFR2. Hepcidin is the master regulator of ironmetabolism and, therefore, most...
muscles. To maintain the necessary levels, humanironmetabolism requires a minimum of iron in the diet. Iron is also the metal at the active site of many...
fertility and menstrual cycle in women. metabolism: diabetes in people with iron overload occurs as a result of selective iron deposition in islet beta cells in...
causing iron deficiency have been studied in rodents, there are no known genetic disorders of humanironmetabolism that directly cause iron deficiency...
values to interpret a specific test (for instance, your own). Humanironmetabolism Serum Iron Archived 2006-10-28 at the Wayback Machine. University of Illinois...
becomes a part of the endogenous iron pool and establishes normal humaniron distribution, metabolism, and elimination. Iron poisoning is a fatal medical...
Child Health and Human Development and she heads the section on humanironmetabolism. Tracey Rouault completed bachelor's degree in biology at Yale College...
film Iron & Blood: Warriors of Ravenloft Humanironmetabolism This disambiguation page lists articles associated with the title Blood and Iron. If an...
in humans is encoded by the CP gene. Ceruloplasmin is the major copper-carrying protein in the blood, and in addition plays a role in ironmetabolism. It...
HEPH, is a protein which in humans is encoded by the HEPH gene. Hephaestin is involved in the metabolism and homeostasis of iron and possibly copper. It is...
Metabolism (/məˈtæbəlɪzəm/, from Greek: μεταβολή metabolē, "change") is the set of life-sustaining chemical reactions in organisms. The three main functions...
Differentiation 71 (CD71), is a protein that in humans is encoded by the TFRC gene. TfR1 is required for iron import from transferrin into cells by endocytosis...
Hepcidin is a protein that in humans is encoded by the HAMP gene. Hepcidin is a key regulator of the entry of iron into the circulation in mammals. During...
Microbial metabolism is the means by which a microbe obtains the energy and nutrients (e.g. carbon) it needs to live and reproduce. Microbes use many different...
simultaneously to prevent tissue damage to the liver and pancreas. HumanironmetabolismIron overload disorder "Aceruloplasminemia | Genetic and Rare Diseases...
intracellular iron-storage protein in both prokaryotes and eukaryotes, keeping iron in a soluble and non-toxic form. In humans, it acts as a buffer against iron deficiency...
hemoglobin, cytochrome (see high-valent iron), and catalase. The average adult human contains about 0.005% body weight of iron, or about four grams, of which three...
calcium and is involved in calcium metabolism, and bone marrow can store iron in ferritin and is involved in ironmetabolism. However, bones are not entirely...
the transport of iron (Fe) through blood plasma. They are produced in the liver and contain binding sites for two Fe3+ ions. Human transferrin is encoded...
Humans (Homo sapiens) or modern humans are the most common and widespread species of primate, and the last surviving species of the genus Homo. They are...
Lucky iron fish are fish-shaped cast iron ingots used to provide dietary supplementation of iron to individuals affected by iron-deficiency anaemia. The...
investigated in non-human animals are those either involved in development (e.g., retinoic acid or hormone metabolism) or involved in the metabolism of toxic compounds...
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