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Choline transporter information


SLC5A7
Identifiers
AliasesSLC5A7, CHT, CHT1, HMN7A, hCHT, Choline transporter, solute carrier family 5 member 7, CMS20
External IDsOMIM: 608761; MGI: 1927126; HomoloGene: 32516; GeneCards: SLC5A7; OMA:SLC5A7 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001305005
NM_001305006
NM_001305007
NM_021815

NM_022025

RefSeq (protein)

NP_001291934
NP_001291935
NP_001291936
NP_068587
NP_001291936.1

NP_071308

Location (UCSC)Chr 2: 107.99 – 108.01 MbChr 17: 54.58 – 54.61 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The high-affinity choline transporter (ChT) also known as solute carrier family 5 member 7 is a protein in humans that is encoded by the SLC5A7 gene.[5] It is a cell membrane transporter and carries choline into acetylcholine-synthesizing neurons.

Hemicholinium-3 is an inhibitor of the ChT and can be used to deplete acetylcholine stores, while coluracetam is an enhancer of the ChT and can increase cholinergic neurotransmission by enhancing acetylcholine synthesis.

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000115665 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000023945 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Solute carrier family 5 (choline transporter), member 7".

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Choline transporter

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Choline

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significantly. Choline is a water-soluble ion and thus requires transporters to pass through fat-soluble cell membranes. Three types of choline transporters are...

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Betaine transporter

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The Betaine/Carnitine/Choline Transporter (BCCT) family proteins are found in Gram-negative and Gram-positive bacteria and archaea. The BCCT family members...

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Acetylcholine

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Kimura H (Feb 2011). "Nuclear choline acetyltransferase activates transcription of a high-affinity choline transporter". The Journal of Biological Chemistry...

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Citicoline

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diphosphate-choline (CDP-Choline) or cytidine 5'-diphosphocholine is an intermediate in the generation of phosphatidylcholine from choline, a common biochemical...

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Acetylcholinesterase

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breakdown of acetylcholine and some other choline esters that function as neurotransmitters: acetylcholine + H2O = choline + acetate It is found at mainly neuromuscular...

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Choline acetyltransferase

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Choline acetyltransferase (commonly abbreviated as ChAT, but sometimes CAT) is a transferase enzyme responsible for the synthesis of the neurotransmitter...

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Anticholinergic

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Choline transporter Inhibitors: Hemicholinium-3 (hemicholine) Triethylcholine Enhancers: Coluracetam VAChTTooltip Vesicular acetylcholine transporter...

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Botulinum toxin

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Cholinergic

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"choline" describes the various quaternary ammonium salts containing the N,N,N-trimethylethanolammonium cation. Found in most animal tissues, choline is...

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Donepezil

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Neostigmine

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that cleaves acetylcholine in the neuromuscular junction into acetate and choline. Neostigmine is an inhibitor of acetylcholinesterase. Neostigmine binds...

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Ethylcholine mustard

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transported into cholinergic neurons by the choline transporter. AF64A irreversibly inhibits the choline acetyltransferase and thereby inhibits acetylcholine...

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Carbaryl

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Choline transporter Inhibitors: Hemicholinium-3 (hemicholine) Triethylcholine Enhancers: Coluracetam VAChTTooltip Vesicular acetylcholine transporter...

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Pyridostigmine

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Reuptake inhibitor

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hyperforin, adhyperforin Choline reuptake inhibitor – hemicholinium-3, triethylcholine Vesicular acetylcholine transporter (VAChT) inhibitor – vesamicol...

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Soman

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central effect. The knowledge of the effects of low doses of soman and other choline esterase inhibitors on rats could possibly be used to explain the relatively...

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Coluracetam

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procognitive effects in cholinergic neurotoxin-treated rats by changing the choline transporter regulation system. Coluracetam is a schedule 4 substance in Australia...

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CHT

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of the National Board of Diving and Hyperbaric Medical Technology Choline transporter (ChT), a protein Cross-sex hormone therapy Chatham Islands / Tuuta...

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Tetrahydrocannabinol

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Pralidoxime

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Huperzine A

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enzyme that catalyzes the breakdown of the neurotransmitter ACh and other choline esters that function as neurotransmitters. The structure of the complex...

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