The genome organisation of HBV; the genes overlap. ORF P, in blue, encodes Hepatitis B virus DNA polymerase.
Identifiers
Organism
Hepatitis B virus ayw/France/Tiollais/1979
Symbol
P
UniProt
P03156
Search for
Structures
Swiss-model
Domains
InterPro
Protein P
Identifiers
Symbol
?
InterPro
IPR037531
Hepatitis B virus DNA polymerase is a hepatitis B viral protein.[1][2] It is a DNA polymerase that can use either DNA or RNA templates and a ribonuclease H that cuts RNA in the duplex. Both functions are supplied by the reverse transcriptase (RT) domain.
^Ono-Nita SK, Kato N, Shiratori Y, Masaki T, Lan KH, Carrilho FJ, Omata M (March 1999). "YMDD motif in hepatitis B virus DNA polymerase influences on replication and lamivudine resistance: A study by in vitro full-length viral DNA transfection". Hepatology. 29 (3): 939–45. doi:10.1002/hep.510290340. PMID 10051501.
^Shaw T, Mok SS, Locarnini SA (November 1996). "Inhibition of hepatitis B virus DNA polymerase by enantiomers of penciclovir triphosphate and metabolic basis for selective inhibition of HBV replication by penciclovir". Hepatology. 24 (5): 996–1002. doi:10.1002/hep.510240504. PMID 8903366.
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