Crystal structures of ferrous and ferrous-no forms of verdoheme in a complex with human heme oxygenase-1: catalytic implications for heme cleavage
Identifiers
Symbol
Heme_oxygenase
Pfam
PF01126
Pfam clan
CL0230
InterPro
IPR016053
PROSITE
PDOC00512
SCOP2
1qq8 / SCOPe / SUPFAM
Membranome
532
Available protein structures:
Pfam
structures / ECOD
PDB
RCSB PDB; PDBe; PDBj
PDBsum
structure summary
Heme oxygenase, or haem oxygenase, (HMOX, commonly abbreviated as HO) is an enzyme that catalyzes the degradation of heme to produce biliverdin, ferrous iron, and carbon monoxide.[1]
There are many heme degrading enzymes in nature. In general, only aerobic heme degrading enzymes are referred to as HMOX-like enzymes whereas anaerobic enzymes are typically not affiliated with the HMOX family.
^Ryter SW, Alam J, Choi AM (April 2006). "Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications". Physiological Reviews. 86 (2): 583–650. doi:10.1152/physrev.00011.2005. PMID 16601269.
Hemeoxygenase, or haem oxygenase, (HMOX, commonly abbreviated as HO) is an enzyme that catalyzes the degradation of heme to produce biliverdin, ferrous...
erythrocytes from the circulation. In the first step, heme is converted to biliverdin by the enzyme hemeoxygenase (HO). NADPH is used as the reducing agent, molecular...
HMOX1 (hemeoxygenase 1 gene) is a human gene that encodes for the enzyme hemeoxygenase 1 (EC 1.14.99.3). Hemeoxygenase (abbreviated HMOX or HO) mediates...
Hemeoxygenase 2 is an enzyme that in humans is encoded by the HMOX2 gene. Hemeoxygenase, an essential enzyme in heme catabolism, cleaves heme to form...
first compound in the porphyrin synthesis pathway, the pathway that leads to heme in mammals, as well as chlorophyll in plants. 5ALA is used in photodynamic...
Retrieved 2008-10-12. Kikuchi, G.; Yoshida, T.; Noguchi, M. (2005). "Hemeoxygenase and heme degradation". Biochemical and Biophysical Research Communications...
microbial P450 monooxygenase research: peroxo-heme intermediates--the central bus station in hemeoxygenase catalysis". Biochem. Biophys. Res. Commun. 338...
mostly produced by the destruction of erythrocytes. Heme is metabolized into biliverdin (via hemeoxygenase) and then into bilirubin (via biliverdin reductase)...
pathways. The most extensively studied pathway is the metabolism of heme by hemeoxygenase which occurs throughout the body with significant activity in the...
gamma (c15), and delta (c20). In the context of heme, metabolic biotransformation by hemeoxygenase results in the selective opening of the alpha-methine...
genes encoding cytoprotective proteins. NRF2 induces the expression of hemeoxygenase 1 in vitro leading to an increase in phase II enzymes. NRF2 also inhibits...
electron transfer from NADPH to cytochrome P450 and other heme proteins including hemeoxygenase in the endoplasmic reticulum of the eukaryotic cell. Human...
extracellular heme can lead to the deactivation of Bach1 repression which leads to the transcriptional activation of antioxidant hemeoxygenase-1 gene. Hemoglobin...
pathways, the best understood of which is the catabolic action of hemeoxygenase on the heme derived from hemoproteins such as hemoglobin. Following the first...
investigated for cancer therapies. ZnPP is a competitive inhibitor of hemeoxygenase. Hemeoxygenase is a cytoprotective enzyme that copes with oxidative stress...
a sign indicating the presence of underlying diseases involving abnormal heme metabolism, liver dysfunction, or biliary-tract obstruction. The prevalence...
N2-(2-carboxyethyl)-L-arginine (CEA) synthase. Clavaminate synthase is a non-hemeoxygenase dependent on iron and α-keto-glutarate and is encoded by orf5 of the...
the "X factor" required for the growth of Haemophilus influenzae. HemeoxygenaseHeme arginate Acute intermittent porphyria Hematin Hemozoin Carbon monoxide-releasing...
majority of endogenous carbon monoxide is produced by hemeoxygenase; the loss of hemeoxygenase and subsequent loss of carbon monoxide signaling has catastrophic...
channels also changes throughout the lifetime. Some studies propose that heme-oxygenase 2 is the transducer; however, since its deletion in mice does not affect...
red blood cells are then degraded to release heme, which will be converted by microsomal hemeoxygenase to iron, carbon monoxide and biliverdin, and are...
released in the degradation (catabolism) of heme by the action of O2, NADPH and the enzyme hemeoxygenase: Heme b + 3 O 2 + 3 2 NADPH + 3 2 H + ⟶ biliverdin...
to heme, it is instead transported across the apical membrane by heme carrier protein 1 (HCP1). Heme is then catabolized by microsomal hemeoxygenase into...
consists of a group of competitive inhibitors of hemeoxygenase, a rate-limiting enzyme in the heme catabolic pathway. Tin mesoporphyrin is one of the...
oxidative stress in the cardiovascular system: focusing on the Bach1/hemeoxygenase-1 pathway". Current Pharmaceutical Biotechnology. 7 (2): 87–93. doi:10...
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