Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references
Chemical compound
Protoporphyrin IX is an organic compound, classified as a porphyrin, that plays an important role in living organisms as a precursor to other critical compounds like heme (hemoglobin) and chlorophyll. It is a deeply colored solid that is not soluble in water. The name is often abbreviated as PPIX.
Protoporphyrin IX contains a porphine core, a tetrapyrrole macrocycle with a marked aromatic character. Protoporphyrin IX is essentially planar, except for the N-H bonds that are bent out of the plane of the rings, in opposite (trans) directions.[2]
^"protoporphyrin IX". pubchem.ncbi.nlm.nih.gov.
^Winslow S. Caughey; James A. Ibers (1977). "Crystal and Molecular Structure of the Free Base Porphyrin, Protoporphyrin IX Dimethyl Ester". J. Am. Chem. Soc. 99 (20): 6639–6645. doi:10.1021/ja00462a027. PMID 19518.
ProtoporphyrinIX is an organic compound, classified as a porphyrin, that plays an important role in living organisms as a precursor to other critical...
Zinc protoporphyrin (ZPP) refers to coordination complexes of zinc and protoporphyrinIX. It is a red-purple solid that is soluble in water. The complex...
In enzymology, a magnesium protoporphyrinIX methyltransferase (EC 2.1.1.11) is an enzyme that catalyzes the chemical reaction S-adenosyl-L-methionine...
in the cytosol and finally gets converted to ProtoporphyrinIX inside the mitochondria. This protoporphyrin molecule chelates with iron in presence of enzyme...
biosynthesis of heme, converting protoporphyrinIX into heme B. It catalyses the reaction: protoheme + 2 H+ = protoporphyrin + Fe2+ Ferrochelatase catalyzes...
Protoporphyrinogen oxidase is responsible for the seventh step in biosynthesis of protoporphyrinIX. This porphyrin is the precursor to hemoglobin, the oxygen carrier...
three-component enzyme (EC 6.6.1.1) that catalyses the insertion of Mg2+ into protoporphyrinIX. This is the first unique step in the synthesis of chlorophyll and...
Derivatives of protoporphyrinIX are common in nature, the precursor to hemes. Octaethylporphyrin (H2OEP) is a synthetic analogue of protoporphyrinIX. Unlike...
that include hemoglobin and chlorophyll. It is a direct precursor of protoporphyrinIX. The compound is a porphyrinogen, meaning that it has a non-aromatic...
Derivatives of protoporphyrinIX are common in nature, the precursor to hemes. Octaethylporphyrin (H2OEP) is a synthetic analogue of protoporphyrinIX. Unlike...
cytotoxic, most probably due to the iron atom contained within its protoporphyrinIX ring, which can act as a Fenton's reagent to catalyze in an unfettered...
structure by indicating its parent molecule was protoporphyrinIX cleaved at the alpha position (see protoporphyrinIX for further information on the Fischer nomenclature...
porphobilinogen (PBG), and four molecules of PBG are coupled, forming protoporphyrinIX. Chlorophyll synthase is the enzyme that completes the biosynthesis...
porphobilinogen (PBG), and four molecules of PBG are coupled, forming protoporphyrinIX. Chlorophyll synthase is the enzyme that completes the biosynthesis...
severe itching and burning sensation of the skin due to the buildup of protoporphyrinIX. One possible treatment was discovered when treating an individual...
Sensibion) is a porphyrin prepared from hemin. It is a derivative of protoporphyrinIX, where the two vinyl groups have been hydrated (converted to alcohols)...
probably evolved to incorporate the iron atom contained within the protoporphyrinIX ring of heme into proteins. As it makes hemeproteins responsive to...
complex. PPO inhibitors poison that enzyme, causing a build up of ProtoporphyrinIX (Proto). Normally Proto is present in very low amounts, but when there...
Chlorophyll and haem (Heme) share a common precursor in the form of ProtoporphyrinIX, and share the same characteristic closed tetrapyrrole ring structure...
studied to detect or monitor other diseases. For example, isolation of protoporphyrinIX from blood samples can be used as a diagnostic tool for atherosclerosis...
where it reacts with protoporphyrin-III oxidase to produce protoporphyrinIX. Iron is then enzymatically inserted into protoporphyrin via ferrochelatase...
by a deficiency in ferrochelatase, leading to the accumulation of protoporphyrinIX in red blood cells, plasma, and tissues. Patients with EPP experience...
such as heme B found in the hemoglobin of human blood. Hemin is protoporphyrinIX containing a ferric iron (Fe3+) ion with a coordinating chloride ligand...
means the bilin's parent compound was protoporphyrinIX cleaved at the alpha-methine bridge (see protoporphyrinIX nomenclature). Origins pertaining to...
sensitizer in photodynamic therapy. It is a prodrug that is metabolized to protoporphyrinIX. It is marketed as Metvix. Metvix cream is applied topically and some...
The light chains are glycosylated and contain the modified iron protoporphyrinIX active site. Together, the light and heavy chains form two identical...
Global Information
