negative regulation of transcription by RNA polymerase II
regulation of transcription involved in G1/S transition of mitotic cell cycle
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter in response to hypoxia
DNA repair
positive regulation of transcription by RNA polymerase II
regulation of transcription involved in G2/M transition of mitotic cell cycle
protein ubiquitination
transcription by RNA polymerase II
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
571
12013
Ensembl
ENSG00000156273
ENSMUSG00000025612
UniProt
O14867
P97302
RefSeq (mRNA)
NM_001011545 NM_001186 NM_206866
NM_007520
RefSeq (protein)
NP_001177 NP_996749
NP_031546
Location (UCSC)
Chr 21: 29.19 – 29.63 Mb
Chr 16: 87.5 – 87.53 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Transcription regulator protein BACH1 is a protein that in humans is encoded by the BACH1 gene.[5][6][7]
^ abcGRCh38: Ensembl release 89: ENSG00000156273 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000025612 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Blouin JL, Duriaux Saïl G, Guipponi M, Rossier C, Pappasavas MP, Antonarakis SE (Mar 1998). "Isolation of the human BACH1 transcription regulator gene, which maps to chromosome 21q22.1". Human Genetics. 102 (3): 282–8. doi:10.1007/s004390050692. PMID 9544839. S2CID 9494442.
^Ohira M, Seki N, Nagase T, Ishikawa K, Nomura N, Ohara O (Jan 1998). "Characterization of a human homolog (BACH1) of the mouse Bach1 gene encoding a BTB-basic leucine zipper transcription factor and its mapping to chromosome 21q22.1". Genomics. 47 (2): 300–6. doi:10.1006/geno.1997.5080. PMID 9479503.
Transcription regulator protein BACH1 is a protein that in humans is encoded by the BACH1 gene. This gene encodes a transcription factor that belongs...
National Library of Medicine. Menichini P, Linial M (November 2001). "SUVi and BACH1: a new subfamily of mammalian helicases?". Mutation Research. 487 (1–2):...
Helicases are a class of enzymes thought to be vital to all organisms. Their main function is to unpack an organism's genetic material. Helicases are motor...
Bach1-sMaf heterodimer is critical for heme metabolism. Knockout mouse studies showed that heme oxygenase-1 gene expression is upregulated in Bach1 knockout...
from similar protein – High-throughput in vitro [53] AAWTANNNBRMCATATGKY BACH1 ENSG00000156273 bZIP Known motif – In vivo/Misc source [54] RTGACTCAGCANWWH...
A, Vingron M, Lehrach H, Yaspo ML (2011). "The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control...
Activation Promotes Lung Cancer Metastasis by Inhibiting the Degradation of Bach1". Cell. 178 (2): 316–329.e18. doi:10.1016/j.cell.2019.06.003. PMC 6625921...
to reduce oxidative stress in the cardiovascular system: focusing on the Bach1/heme oxygenase-1 pathway". Current Pharmaceutical Biotechnology. 7 (2):...
-dependent uptake of extracellular heme can lead to the deactivation of Bach1 repression which leads to the transcriptional activation of antioxidant...
"Heme induces ubiquitination and degradation of the transcription factor Bach1". Molecular and Cellular Biology. 27 (19): 6962–71. doi:10.1128/MCB.02415-06...
HJ, Schmidt D, Manke T, et al. (July 2011). "The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control...
Sultan M, Borodina T, et al. (July 2011). "The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control...
Vingron M, Lehrach H, Yaspo ML (July 2011). "The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control...
Vingron M, Lehrach H, Yaspo ML (July 2011). "The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control...
Grossman S, Wahrer DC, Sgroi DC, Lane WS, Haber DA, Livingston DM (Apr 2001). "BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes...
(NFE2), Nrf1 (NFE2L1), Nrf2 (NFE2L2), and Nrf3 (NFE2L3)] and Bach proteins (BACH1 and BACH2). sMaf homodimers bind to a palindromic DNA sequence called the...
Vingron M, Lehrach H, Yaspo ML (July 2011). "The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control...
metabolizing enzyme genes. The Bach1-sMaf heterodimer regulates the heme oxygenase-1 gene. In particular, it has been reported that Bach1-MafG heterodimers participate...
"Mutational analysis of the BRCA1-interacting genes ZNF350/ZBRK1 and BRIP1/BACH1 among BRCA1 and BRCA2-negative probands from breast-ovarian cancer families...
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