Cytochrome P450 reductase (also known as NADPH:ferrihemoprotein oxidoreductase, NADPH:hemoprotein oxidoreductase, NADPH:P450 oxidoreductase, P450 reductase, POR, CPR, CYPOR) is a membrane-bound enzyme required for electron transfer from NADPH to cytochrome P450[5] and other heme proteins including heme oxygenase in the endoplasmic reticulum[6] of the eukaryotic cell.
^ abcGRCh38: Ensembl release 89: ENSG00000127948 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000005514 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Pandey AV, Flück CE (May 2013). "NADPH P450 oxidoreductase: structure, function, and pathology of diseases". Pharmacology & Therapeutics. 138 (2): 229–54. doi:10.1016/j.pharmthera.2013.01.010. PMID 23353702.
^Jensen K, Møller BL (February 2010). "Plant NADPH-cytochrome P450 oxidoreductases". Phytochemistry. 71 (2–3): 132–41. Bibcode:2010PChem..71..132J. doi:10.1016/j.phytochem.2009.10.017. PMID 19931102. CPR was shown to be localized in the endoplasmic reticulum in the early 1960s (Williams and Kamin, 1962).
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CytochromesP450 (P450s or CYPs) are a superfamily of enzymes containing heme as a cofactor that mostly, but not exclusively, function as monooxygenases...
cytochromeP450reductase binding site—as seen in HB plot—transform CYP2B4 to a conformation state, where binding of NADPH cytochromeP450reductase occurs...
NADPH:cytochromeP450reductase The general scheme of electron flow in the POR/P450 system is: NADPH → FAD → FMN → P450 → O2 Reduced (ferrous) cytochrome P450...
cytochrome classes, several additional classifications such as cytochrome o and cytochromeP450 can be found in biochemical literature. Cytochromes were...
CytochromeP450 oxidoreductase deficiency (PORD) is a rare disease and inborn error of metabolism caused by deficiency of cytochromeP450 oxidoreductase...
Spanish preposition Por, a Portuguese preposition POR (gene), cytochromeP450reductase Portugal, IOC country code Power-on reset Program of Record (PoR)...
Epoxygenases are a set of membrane-bound, heme-containing cytochromeP450 (CYP P450 or just CYP) enzymes that metabolize polyunsaturated fatty acids to...
heme-thiolate proteins, and a multi-domain C-terminal reductase, which is homologous to NADPH:cytochromeP450reductase (EC 1.6.2.4) and other flavoproteins. The...
23-46. Voznesensky, A. I.; Schenkman, J. B. The cytochromeP450 2B4-NADPH cytochromeP450reductase electron transfer complex is not formed by charge-pairing...
prosthetic groups. The activity of HO-1 is dependent upon NADPH-CytochromeP450Reductase. HO-1 is a stress-induced isoform present throughout the body...
nucleotides. In a recent study Rifampicin was shown to bind to cytochromeP450reductase and alter its conformation as well as activity towards supporting...
Roots I (2001). "Co-expression of human cytochrome P4501A1 (CYP1A1) variants and human NADPH-cytochromeP450reductase in the baculovirus/insect cell system"...
species (ROS) in the presence of oxidoreductive enzymes such as cytochromeP450reductase, NADH dehydrogenase and xanthine oxidase. Converting quinone to...
oxygenase-1 (hHO-1) in conjunction with cytochromep450reductase to catalyzes the NADPH-cytochromeP450reductase-dependent oxidation of heme to biliverdin...
"The binding sites on human heme oxygenase-1 for cytochromep450reductase and biliverdin reductase". The Journal of Biological Chemistry. 278 (22): 20069–76...
and/or methemoglobinemia, similarly to deficiency of cytochrome b5 reductase (methemoglobin reductase). Mark A. Sperling (10 April 2014). Pediatric Endocrinology...
Adrenodoxin reductase is a flavoprotein as it carries a FAD type coenzyme. The enzyme functions as the first electron transfer protein of mitochondrial P450 systems...
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