TGF beta 1 information

TGFB1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1KLA, 1KLC, 1KLD, 3KFD, 4KV5
Identifiers
Aliases	TGFB1, CED, DPD1, LAP, TGFB, TGFbeta, transforming growth factor beta 1, IBDIMDE, TGF-beta1
External IDs	OMIM: 190180 MGI: 98725 HomoloGene: 540 GeneCards: TGFB1
Gene location (Human)
Chr.	Chromosome 19 (human)
End	41,353,922 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	25,404,502 bp
RNA expression pattern
	Top expressed in
	monocyte; ; stromal cell of endometrium; ; ascending aorta; ; right coronary artery; ; spleen; ; right lung; ; canal of the cervix; ; blood; ; upper lobe of left lung; ; left coronary artery;
	Top expressed in
	molar; ; calvaria; ; spleen; ; thymus; ; body of femur; ; ankle; ; lip; ; blood; ; subcutaneous adipose tissue; ; yolk sac;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	type II transforming growth factor beta receptor binding; protein N-terminus binding; cytokine activity; enzyme binding; growth factor activity; antigen binding; type I transforming growth factor beta receptor binding; protein homodimerization activity; protein serine/threonine kinase activator activity; protein binding; protein heterodimerization activity; type III transforming growth factor beta receptor binding; transforming growth factor beta receptor binding; identical protein binding;
Cellular component	cytoplasm; extracellular region; nucleus; microvillus; cell surface; blood microparticle; plasma membrane; secretory granule; axon; neuronal cell body; Golgi lumen; platelet alpha granule lumen; extracellular matrix; extracellular space;
Biological process	positive regulation of histone deacetylation; positive regulation of transcription regulatory region DNA binding; ureteric bud development; tolerance induction to self antigen; positive regulation of protein phosphorylation; endoderm development; response to cholesterol; positive regulation of MAP kinase activity; regulation of sodium ion transport; response to progesterone; negative regulation of cell cycle; response to organic substance; mammary gland development; T cell homeostasis; negative regulation of ossification; negative regulation of hyaluronan biosynthetic process; protein phosphorylation; T cell differentiation; positive regulation of vascular permeability; animal organ regeneration; positive regulation of blood vessel endothelial cell migration; negative regulation of epithelial cell proliferation; regulation of binding; inner ear development; myelination; negative regulation of macrophage cytokine production; cell population proliferation; transforming growth factor beta receptor signaling pathway; face morphogenesis; negative regulation of cell population proliferation; positive regulation of receptor clustering; regulation of apoptotic process; positive regulation of collagen biosynthetic process; cellular response to transforming growth factor beta stimulus; pathway-restricted SMAD protein phosphorylation; regulation of DNA binding; regulation of actin cytoskeleton reorganization; negative regulation of fat cell differentiation; positive regulation of protein metabolic process; cell-cell junction organization; negative regulation of myoblast differentiation; positive regulation of protein kinase B signaling; common-partner SMAD protein phosphorylation; positive regulation of branching involved in ureteric bud morphogenesis; SMAD protein signal transduction; epidermal growth factor receptor signaling pathway; macrophage derived foam cell differentiation; negative regulation of blood vessel endothelial cell migration; positive regulation of protein dephosphorylation; extrinsic apoptotic signaling pathway; negative regulation of extracellular matrix disassembly; mitotic cell cycle checkpoint signaling; positive regulation of fibroblast proliferation; negative regulation of cell differentiation; regulation of branching involved in mammary gland duct morphogenesis; positive regulation of exit from mitosis; negative regulation of transforming growth factor beta receptor signaling pathway; negative regulation of gene expression; morphogenesis of a branching structure; regulation of SMAD protein signal transduction; positive regulation of peptidyl-serine phosphorylation; cell activation; negative regulation of neuroblast proliferation; positive regulation of transcription, DNA-templated; cell growth; negative regulation of T cell proliferation; response to wounding; negative regulation of cell growth; positive regulation of chemotaxis; protein export from nucleus; regulation of protein import into nucleus; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein import into nucleus; positive regulation of cardiac muscle cell differentiation; oligodendrocyte development; positive regulation of interleukin-17 production; inflammatory response; negative regulation of interleukin-17 production; lymph node development; T cell activation; Notch signaling pathway; negative regulation of protein phosphorylation; regulation of blood vessel remodeling; SMAD protein complex assembly; regulation of striated muscle tissue development; response to vitamin D; chondrocyte differentiation; regulatory T cell differentiation; regulation of cartilage development; branch elongation involved in mammary gland duct branching; positive regulation of bone mineralization; positive regulation of epithelial cell proliferation; female pregnancy; cellular response to organic cyclic compound; positive regulation of extracellular matrix assembly; cellular calcium ion homeostasis; wound healing; negative regulation of transcription by RNA polymerase II; response to glucose; positive regulation of epithelial to mesenchymal transition; cellular response to dexamethasone stimulus; negative regulation of production of miRNAs involved in gene silencing by miRNA; mitigation of host defenses by virus; lens fiber cell differentiation; positive regulation of NF-kappaB transcription factor activity; extracellular matrix assembly; ATP biosynthetic process; hematopoietic progenitor cell differentiation; regulation of interleukin-23 production; positive regulation of protein secretion; frontal suture morphogenesis; epithelial to mesenchymal transition; phosphate-containing compound metabolic process; regulation of gene expression; adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains; negative regulation of release of sequestered calcium ion into cytosol; response to radiation; mononuclear cell proliferation; negative regulation of transcription, DNA-templated; negative regulation of T cell activation; positive regulation of odontogenesis; lipopolysaccharide-mediated signaling pathway; positive regulation of protein localization to nucleus; response to estradiol; regulation of cell migration; response to hypoxia; hyaluronan catabolic process; negative regulation of phagocytosis; response to organic cyclic compound; positive regulation of protein-containing complex assembly; protein kinase B signaling; negative regulation of cell-cell adhesion; negative regulation of gene silencing by miRNA; positive regulation of regulatory T cell differentiation; cellular response to growth factor stimulus; positive regulation of pathway-restricted SMAD protein phosphorylation; mammary gland branching involved in thelarche; response to laminar fluid shear stress; human ageing; regulation of regulatory T cell differentiation; platelet degranulation; negative regulation of DNA replication; myeloid dendritic cell differentiation; salivary gland morphogenesis; receptor catabolic process; MAPK cascade; positive regulation of histone acetylation; regulation of transforming growth factor beta receptor signaling pathway; positive regulation of phosphatidylinositol 3-kinase activity; negative regulation of protein localization to plasma membrane; positive regulation of NAD+ ADP-ribosyltransferase activity; negative regulation of immune response; regulation of cell population proliferation; negative regulation of skeletal muscle tissue development; positive regulation of peptidyl-threonine phosphorylation; positive regulation of smooth muscle cell differentiation; positive regulation of isotype switching to IgA isotypes; connective tissue replacement involved in inflammatory response wound healing; ossification involved in bone remodeling; positive regulation of apoptotic process; positive regulation of vascular endothelial growth factor production; positive regulation of superoxide anion generation; digestive tract development; cell migration; positive regulation of fibroblast migration; positive regulation of cell division; germ cell migration; positive regulation of transcription by RNA polymerase II; negative regulation of mitotic cell cycle; positive regulation of SMAD protein signal transduction; positive regulation of pri-miRNA transcription by RNA polymerase II; positive regulation of gene expression; positive regulation of cell population proliferation; liver regeneration; regulation of epithelial to mesenchymal transition involved in endocardial cushion formation; positive regulation of mononuclear cell migration; cellular response to insulin-like growth factor stimulus; positive regulation of cell migration; response to immobilization stress; cellular response to mechanical stimulus; cellular response to ionizing radiation; vasculogenesis; neural tube closure; heart valve morphogenesis; heart development; neural tube development; membrane protein intracellular domain proteolysis; leukocyte migration; ventricular cardiac muscle tissue morphogenesis; positive regulation of ERK1 and ERK2 cascade; transforming growth factor beta receptor signaling pathway involved in heart development; embryonic liver development; BMP signaling pathway; cell development; apoptotic process; regulation of pri-miRNA transcription by RNA polymerase II; positive regulation of production of miRNAs involved in gene silencing by miRNA; regulation of signaling receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	7040
	21803
	ENSG00000105329
	ENSMUSG00000002603
	P01137
	P04202
	NM_000660
	NM_011577
	NP_000651
	NP_035707
	Wikidata
View/Edit Human	View/Edit Mouse

Transforming growth factor beta 1 or TGF-β1 is a polypeptide member of the transforming growth factor beta superfamily of cytokines. It is a secreted protein that performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation, and apoptosis. In humans, TGF-β1 is encoded by the TGFB1 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000105329 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000002603 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ghadami M, Makita Y, Yoshida K, Nishimura G, Fukushima Y, Wakui K, Ikegawa S, Yamada K, Kondo S, Niikawa N, Tomita Ha (January 2000). "Genetic mapping of the Camurati-Engelmann disease locus to chromosome 19q13.1-q13.3". Am. J. Hum. Genet. 66 (1): 143–7. doi:10.1086/302728. PMC 1288319. PMID 10631145.
^ Vaughn SP, Broussard S, Hall CR, Scott A, Blanton SH, Milunsky JM, Hecht JT (May 2000). "Confirmation of the mapping of the Camurati-Englemann locus to 19q13. 2 and refinement to a 3.2-cM region". Genomics. 66 (1): 119–21. doi:10.1006/geno.2000.6192. PMID 10843814.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000105329 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000002603 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10631145-5] Ghadami M, Makita Y, Yoshida K, Nishimura G, Fukushima Y, Wakui K, Ikegawa S, Yamada K, Kondo S, Niikawa N, Tomita Ha (January 2000). "Genetic mapping of the Camurati-Engelmann disease locus to chromosome 19q13.1-q13.3". Am. J. Hum. Genet. 66 (1): 143–7. doi:10.1086/302728. PMC 1288319. PMID 10631145.

[pmid10843814-6] Vaughn SP, Broussard S, Hall CR, Scott A, Blanton SH, Milunsky JM, Hecht JT (May 2000). "Confirmation of the mapping of the Camurati-Englemann locus to 19q13. 2 and refinement to a 3.2-cM region". Genomics. 66 (1): 119–21. doi:10.1006/geno.2000.6192. PMID 10843814.

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