Class of enzymes which transfer an –SO3 group to glycoproteins and lipids
Carbohydrate Sulfotransferase family 2
Example carbohydrate sulfotransferase with PAPS cosubstrate and carbohydrate substrate: Crystal Structure of human 3-O-Sulfotransferase-3 with bound PAPS and tetrasaccharide substrate. Enzyme chain A (blue), Enzyme chain B (green), PAPS (red), tetrasaccharide substrate (white), sodium ion (purple sphere).[1]
Identifiers
Symbol
Sulfotransfer_2
Pfam
PF03567
InterPro
IPR005331
Membranome
495
Available protein structures:
Pfam
structures / ECOD
PDB
RCSB PDB; PDBe; PDBj
PDBsum
structure summary
Carbohydrate Sulfotransferase family 1
Identifiers
Symbol
Sulfotransfer_1
InterPro
IPR016469
Membranome
493
In biochemistry, carbohydrate sulfotransferases are enzymes within the class of sulfotransferases which catalyze the transfer of the sulfate (−SO−3) functional group to carbohydrate groups in glycoproteins and glycolipids. Carbohydrates are used by cells for a wide range of functions from structural purposes to extracellular communication. Carbohydrates are suitable for such a wide variety of functions due to the diversity in structure generated from monosaccharide composition, glycosidic linkage positions, chain branching, and covalent modification.[2] Possible covalent modifications include acetylation, methylation, phosphorylation, and sulfation.[3] Sulfation, performed by carbohydrate sulfotransferases, generates carbohydrate sulfate esters (−O−SO−3). These sulfate esters are only located extracellularly, whether through excretion into the extracellular matrix (ECM) or by presentation on the cell surface.[4] As extracellular compounds, sulfated carbohydrates are mediators of intercellular communication, cellular adhesion, and ECM maintenance.
^Moon, AF.; Edavettal, SC.; Krahn, JM.; Munoz, EM.; Negishi, M.; Linhardt, RJ.; Liu, J.; Pedersen, LC. (Oct 2004). "Structural analysis of the sulfotransferase (3-o-sulfotransferase isoform 3) involved in the biosynthesis of an entry receptor for herpes simplex virus 1". J Biol Chem. 279 (43): 45185–93. doi:10.1074/jbc.M405013200. PMC 4114238. PMID 15304505.
^Nelson, R M; Venot, A; Bevilacqua, M P; Linhardt, R J; Stamenkovic, I (1995). "Carbohydrate-Protein Interactions in Vascular Biology". Annual Review of Cell and Developmental Biology. 11 (1): 601–631. doi:10.1146/annurev.cb.11.110195.003125. ISSN 1081-0706. PMID 8689570.
^Hooper, L.V.; Baenziger, J.U. (1993). "Sulfotransferase and Glycosyltransferase Analyses Using a 96-Well Filtration Plate". Analytical Biochemistry. 212 (1): 128–133. doi:10.1006/abio.1993.1301. ISSN 0003-2697. PMID 8368484.
In biochemistry, carbohydratesulfotransferases are enzymes within the class of sulfotransferases which catalyze the transfer of the sulfate (−SO−3) functional...
sulfonation via sulfotransferases may be part of a protein, lipid, carbohydrate or steroid. The following are examples of sulfotransferases: carbohydrate sulfotransferase:...
Carbohydratesulfotransferase 4 is an enzyme that in humans is encoded by the CHST4 gene. GRCh38: Ensembl release 89: ENSG00000140835 – Ensembl, May 2017...
Carbohydratesulfotransferase 10 is an enzyme that in humans is encoded by the CHST10 gene. Cell surface carbohydrates modulate a variety of cellular functions...
to be autosomal recessive, caused by mutation in the CHST14 (carbohydratesulfotransferase 14) gene. This syndrome is characterised by typical facial appearance...
Carbohydratesulfotransferase 5 is an enzyme that in humans is encoded by the CHST5 gene. GRCh38: Ensembl release 89: ENSG00000135702 – Ensembl, May 2017...
Carbohydratesulfotransferase 14 is an enzyme that in humans is encoded by the CHST14 gene. CHST14, a protein-coding gene, encodes for the enzyme carbohydrate...
Carbohydratesulfotransferase 6 is an enzyme that in humans is encoded by the CHST6 gene. It codes for an enzyme necessary for the production of keratan...
Carbohydratesulfotransferase 2 is an enzyme that in humans is encoded by the CHST2 gene. GRCh38: Ensembl release 89: ENSG00000175040 – Ensembl, May 2017...
Carbohydratesulfotransferase 11 is an enzyme that in humans is encoded by the CHST11 gene. Mutations in this gene have been associated to susceptibility...
Carbohydratesulfotransferase 7 is an enzyme that in humans is encoded by the CHST7 gene. This gene belongs to the sulfotransferase gene family. Sulfotransferases...
Carbohydratesulfotransferase 12 is an enzyme that in humans is encoded by the CHST12 gene. GRCh38: Ensembl release 89: ENSG00000136213 – Ensembl, May...
Carbohydratesulfotransferase 1 is an enzyme that in humans is encoded by the CHST1 gene. GRCh38: Ensembl release 89: ENSG00000175264 – Ensembl, May 2017...
Peeling skin syndrome 3 is caused by a genetic defect in the carbohydratesulfotransferase (CHST8) gene. This gene is characterized by a way of asymptomatic...
autosomal recessive genetic disorder caused by mutations in the carbohydratesulfotransferase gene (CHST6), resulting in abnormal proteoglycan synthesis....
by 2-O sulfation of the uronic acid sugar by 2-O sulfotransferase (Heparan sulfate 2-O-sulfotransferase). Finally, the 6-O and 3-O positions of GlcNAc moities...
dystrophy: is a congenital disease resulted from malfunction of GlcNAc-6-sulfotransferase. Congenital disorder in α-1,3 mannosyl transferase will result in a...
classes of sulfotransferases and an epimerase. The availability of the sulfate donor PAPS is crucial to the activity of the sulfotransferases. The first...
Hemmerich, Stefan (2006). "Induction of PNAd and N-acetylglucosamine 6-O-sulfotransferases 1 and 2 in mouse collagen-induced arthritis". BMC Immunology. 7 (12):...
sulfated glycosaminoglycans in the extracellular space. Together with sulfotransferases, sulfatases form the major catalytic machinery for the synthesis and...
metabolites of aromatic hydrocarbons, are substrates for both UDP-GT and sulfotransferases. Glucuronides predominate with phenol or a phenol precursor (benzene)...
Galactose-3-O-sulfotransferase 3 is an enzyme that in humans is encoded by the GAL3ST3 gene. This gene encodes a member of the galactose-3-O-sulfotransferase protein...
Bhakta S, Lee JK, Belov YY, Gunn MD, Zuo FR, et al. (May 1999). "Sulfotransferases of two specificities function in the reconstitution of high endothelial...
17β-hydroxysteroid dehydrogenase 2 (converts estradiol into estrone) and estrone sulfotransferase (converts estrone into estrone sulfate). The antiestrogenic effects...
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