Monoclonal antibody
Gevokizumab Type Whole antibody Source Humanized (from mouse) Target Interleukin 1β ATC code CAS Number 1129435-60-4 N ChemSpider UNII KEGG Formula C 6442 H 9962 N 1710 O 2010 S 52 Molar mass 145193 .64 g·mol−1 N Y (what is this?) (verify)
Gevokizumab is an experimental monoclonal antibody, developed by XOMA Corporation, with allosteric modulating properties. Gevokizumab binds to interleukin-1 beta (IL-1 beta),[1] a pro-inflammatory cytokine, and downmodulates the cellular signaling events that produce inflammation. IL-1 beta has been implicated in cardiovascular conditions, lung cancer, and auto-inflammatory diseases.
On August 25, 2017, XOMA Corporation licensed the global commercial rights to gevokizumab to Novartis. Under the license agreement, Novartis will have worldwide rights to gevokizumab, and will be solely responsible for the development and commercialization of antibodies and products containing antibodies arising from gevokizumab. XOMA received an approximately $16 million upfront payment, and Novartis repaid in its entirety the approximately €12 million of debt owed by XOMA to Les Laboratoires Servier. XOMA is eligible to receive up to $438 million in development, regulatory and commercial milestones plus tiered high-single to mid-double-digit royalties on net sales of gevokizumab.
^ Knickelbein JE, Tucker WR, Bhatt N, Armbrust K, Valent D, Obiyor D, et al. (December 2016). "Gevokizumab in the Treatment of Autoimmune Non-necrotizing Anterior Scleritis: Results of a Phase I/II Clinical Trial". American Journal of Ophthalmology . 172 : 104–110. doi:10.1016/j.ajo.2016.09.017. PMC 5121021 . PMID 27663070.
Last Update: 2023-09-26T14:21:50Z
Gevokizumab is an experimental monoclonal antibody, developed by XOMA Corporation, with allosteric modulating properties. Gevokizumab binds to interleukin-1...
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Last Update: 2024-04-23T14:41:01Z
Antagonists: AF-12198 Anakinra IL-1RA Isunakinra Antibodies: Canakinumab Gevokizumab Lutikizumab Decoy receptors: Rilonacept (IL-1 Trap) IL-2 Agonists: Adargileukin...
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Last Update: 2024-04-07T06:14:24Z
Antagonists: AF-12198 Anakinra IL-1RA Isunakinra Antibodies: Canakinumab Gevokizumab Lutikizumab Decoy receptors: Rilonacept (IL-1 Trap) IL-2 Agonists: Adargileukin...
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Last Update: 2024-04-27T02:35:32Z
Antagonists: AF-12198 Anakinra IL-1RA Isunakinra Antibodies: Canakinumab Gevokizumab Lutikizumab Decoy receptors: Rilonacept (IL-1 Trap) IL-2 Agonists: Adargileukin...
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Last Update: 2024-04-27T02:59:44Z
Antagonists: AF-12198 Anakinra IL-1RA Isunakinra Antibodies: Canakinumab Gevokizumab Lutikizumab Decoy receptors: Rilonacept (IL-1 Trap) IL-2 Agonists: Adargileukin...
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Last Update: 2024-04-14T05:42:28Z
Antagonists: AF-12198 Anakinra IL-1RA Isunakinra Antibodies: Canakinumab Gevokizumab Lutikizumab Decoy receptors: Rilonacept (IL-1 Trap) IL-2 Agonists: Adargileukin...
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Last Update: 2024-04-17T06:53:02Z
Antagonists: AF-12198 Anakinra IL-1RA Isunakinra Antibodies: Canakinumab Gevokizumab Lutikizumab Decoy receptors: Rilonacept (IL-1 Trap) IL-2 Agonists: Adargileukin...
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Last Update: 2024-04-23T21:00:54Z
Antagonists: AF-12198 Anakinra IL-1RA Isunakinra Antibodies: Canakinumab Gevokizumab Lutikizumab Decoy receptors: Rilonacept (IL-1 Trap) IL-2 Agonists: Adargileukin...
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Last Update: 2024-03-15T07:13:16Z
Antagonists: AF-12198 Anakinra IL-1RA Isunakinra Antibodies: Canakinumab Gevokizumab Lutikizumab Decoy receptors: Rilonacept (IL-1 Trap) IL-2 Agonists: Adargileukin...
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Last Update: 2024-04-20T03:30:36Z
Antagonists: AF-12198 Anakinra IL-1RA Isunakinra Antibodies: Canakinumab Gevokizumab Lutikizumab Decoy receptors: Rilonacept (IL-1 Trap) IL-2 Agonists: Adargileukin...
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Last Update: 2024-02-26T14:00:14Z
Antagonists: AF-12198 Anakinra IL-1RA Isunakinra Antibodies: Canakinumab Gevokizumab Lutikizumab Decoy receptors: Rilonacept (IL-1 Trap) IL-2 Agonists: Adargileukin...
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Last Update: 2023-12-01T20:57:17Z
Tralokinumab Ustekinumab Humanized Anrukinzumab Bimekizumab Clazakizumab Gevokizumab Ixekizumab Mirikizumab† Lebrikizumab Olokizumab† Perakizumab Risankizumab...
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Last Update: 2024-04-26T18:57:18Z
Antagonists: AF-12198 Anakinra IL-1RA Isunakinra Antibodies: Canakinumab Gevokizumab Lutikizumab Decoy receptors: Rilonacept (IL-1 Trap) IL-2 Agonists: Adargileukin...
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Last Update: 2024-03-28T06:50:00Z
Antagonists: AF-12198 Anakinra IL-1RA Isunakinra Antibodies: Canakinumab Gevokizumab Lutikizumab Decoy receptors: Rilonacept (IL-1 Trap) IL-2 Agonists: Adargileukin...
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Last Update: 2023-11-27T23:02:19Z
Antagonists: AF-12198 Anakinra IL-1RA Isunakinra Antibodies: Canakinumab Gevokizumab Lutikizumab Decoy receptors: Rilonacept (IL-1 Trap) IL-2 Agonists: Adargileukin...
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Last Update: 2023-09-06T17:09:04Z
Antagonists: AF-12198 Anakinra IL-1RA Isunakinra Antibodies: Canakinumab Gevokizumab Lutikizumab Decoy receptors: Rilonacept (IL-1 Trap) IL-2 Agonists: Adargileukin...
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Last Update: 2024-03-13T06:40:07Z
Antagonists: AF-12198 Anakinra IL-1RA Isunakinra Antibodies: Canakinumab Gevokizumab Lutikizumab Decoy receptors: Rilonacept (IL-1 Trap) IL-2 Agonists: Adargileukin...
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Last Update: 2024-03-08T11:05:29Z
Antagonists: AF-12198 Anakinra IL-1RA Isunakinra Antibodies: Canakinumab Gevokizumab Lutikizumab Decoy receptors: Rilonacept (IL-1 Trap) IL-2 Agonists: Adargileukin...
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Last Update: 2024-04-29T05:37:30Z
Antagonists: AF-12198 Anakinra IL-1RA Isunakinra Antibodies: Canakinumab Gevokizumab Lutikizumab Decoy receptors: Rilonacept (IL-1 Trap) IL-2 Agonists: Adargileukin...
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Last Update: 2024-04-02T18:59:06Z
Antagonists: AF-12198 Anakinra IL-1RA Isunakinra Antibodies: Canakinumab Gevokizumab Lutikizumab Decoy receptors: Rilonacept (IL-1 Trap) IL-2 Agonists: Adargileukin...
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Last Update: 2024-04-10T06:41:00Z
Antagonists: AF-12198 Anakinra IL-1RA Isunakinra Antibodies: Canakinumab Gevokizumab Lutikizumab Decoy receptors: Rilonacept (IL-1 Trap) IL-2 Agonists: Adargileukin...
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Last Update: 2024-04-07T05:29:31Z
Antagonists: AF-12198 Anakinra IL-1RA Isunakinra Antibodies: Canakinumab Gevokizumab Lutikizumab Decoy receptors: Rilonacept (IL-1 Trap) IL-2 Agonists: Adargileukin...
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Last Update: 2024-04-11T19:32:12Z
Antagonists: AF-12198 Anakinra IL-1RA Isunakinra Antibodies: Canakinumab Gevokizumab Lutikizumab Decoy receptors: Rilonacept (IL-1 Trap) IL-2 Agonists: Adargileukin...
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Last Update: 2024-03-13T06:37:38Z
Antagonists: AF-12198 Anakinra IL-1RA Isunakinra Antibodies: Canakinumab Gevokizumab Lutikizumab Decoy receptors: Rilonacept (IL-1 Trap) IL-2 Agonists: Adargileukin...
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Last Update: 2023-12-20T20:04:18Z
Antagonists: AF-12198 Anakinra IL-1RA Isunakinra Antibodies: Canakinumab Gevokizumab Lutikizumab Decoy receptors: Rilonacept (IL-1 Trap) IL-2 Agonists: Adargileukin...
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Last Update: 2024-04-29T03:54:23Z
Antagonists: AF-12198 Anakinra IL-1RA Isunakinra Antibodies: Canakinumab Gevokizumab Lutikizumab Decoy receptors: Rilonacept (IL-1 Trap) IL-2 Agonists: Adargileukin...
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