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Factor VII deficiency information


Factor VII deficiency
Other namesHypoproconvertinemia
This condition is inherited in an autosomal recessive manner.
SpecialtyHematology, medical genetics Edit this on Wikidata

Factor VII deficiency is a bleeding disorder characterized by a lack in the production of Factor VII (FVII) (proconvertin), a protein that causes blood to clot in the coagulation cascade. After a trauma factor VII initiates the process of coagulation in conjunction with tissue factor (TF/factor III) in the extrinsic pathway.[citation needed]

The condition may be inherited or acquired. It is the most common of the rare congenital coagulation disorders.[1]

  1. ^ Guglielmo Mariani, Francesco Bernardi (2009). "Factor VII Deficiency". Semin. Thromb. Hemost. 35 (4): 400–406. doi:10.1055/s-0029-1225762. PMID 19598068.

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Factor VII deficiency

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distinguish factor deficiencies from factor inhibitors, such as lupus anticoagulant, or specific factor inhibitors, such as antibodies directed against factor VIII...

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hemophilia A) is a blood clotting disorder caused by a genetic deficiency in clotting factor VIII, thereby resulting in significant susceptibility to bleeding...

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models, mutations within the promoter region of factor IX have an age-dependent phenotype. Factors VII, IX, and X all play key roles in blood coagulation...

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it should only be used in clinical trials or with patients with factor VII deficiency. A new product of this type (Cresilon Hemostatic Gel or CHG, Vetigel...

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appear to decrease the mortality rate. In those without previous factor VII deficiency, its use is not recommended outside of trial situations. Other medications...

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and X. Some versions also contain factor VII. It is used to treat and prevent bleeding in hemophilia B if pure factor IX is not available. It may also...

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and confusion. In Western countries, chronic alcoholism is a risk factor for deficiency. Also at risk are older adults, persons with HIV/AIDS or diabetes...

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bleeding. The PT evaluates coagulation factors I, II, V, VII and X, while the PTT evaluates coagulation factors I, II, V, VIII, IX, X, XI and XII. The...

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splice site mutation in the human gene for plasma factor VII that causes severe plasma factor VII deficiency, bleeding disease, results from a 251 bp NUMT...

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which a congenital deficiency has not been described. In addition to the membrane-bound tissue factor, soluble form of tissue factor was also found which...

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intermediate. The presence of uncarboxylated proteins indicates a vitamin K deficiency. Carboxylation allows them to bind (chelate) calcium ions, which they...

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