An ultrasound image demonstrating a blood clot in the left common femoral vein.
Specialty
Hematology
Thrombophilia (sometimes called hypercoagulability or a prothrombotic state) is an abnormality of blood coagulation that increases the risk of thrombosis (blood clots in blood vessels).[1][2] Such abnormalities can be identified in 50% of people who have an episode of thrombosis (such as deep vein thrombosis in the leg) that was not provoked by other causes.[3] A significant proportion of the population has a detectable thrombophilic abnormality, but most of these develop thrombosis only in the presence of an additional risk factor.[2]
There is no specific treatment for most thrombophilias, but recurrent episodes of thrombosis may be an indication for long-term preventive anticoagulation.[2] The first major form of thrombophilia to be identified by medical science, antithrombin deficiency, was identified in 1965, while the most common abnormalities (including factor V Leiden) were described in the 1990s.[4][5]
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Thrombophilia (sometimes called hypercoagulability or a prothrombotic state) is an abnormality of blood coagulation that increases the risk of thrombosis...
about heredity and factor V Leiden thrombophilia? http://www.genome.gov/15015167#Q5 "Factor V Leiden thrombophilia: MedlinePlus Genetics". Rodger MA,...
excludes thrombocytosis from the scope of thrombophilia by definition, but practically, by the definition of thrombophilia as an increased predisposition to thrombosis...
carriers who developed VTE. In those who develop VTE, the results of thrombophilia tests (wherein the variant can be detected) rarely play a role in the...
qualitative deficiency of either (protein C or protein S) may lead to thrombophilia (a tendency to develop thrombosis). Impaired action of Protein C (activated...
clot formation (thrombus), also known as a hypercoagulable state or thrombophilia. Coagulopathy may cause uncontrolled internal or external bleeding....
trauma/broken bones and extended air travel. Hypercoagulability (also called thrombophilia; any disorder of the blood that predisposes to thrombosis); Common causes...
development of CRVO, a systematic review found no increased prevalence of thrombophilia (an inherent propensity to thrombosis) in patients with retinal vascular...
fibroids, endometrial polyps, intrauterine adhesions, adenomyosis, thrombophilia and endometriosis, can reduce the chances of implantation and result...
therapy, menopausal hormone therapy and hormonal contraceptives) Genetic thrombophilia (factor V Leiden, prothrombin mutation G20210A, protein C deficiency...
for short, formerly known as the National Alliance for Thrombosis and Thrombophilia (NATT), is a United States nationwide not-for-profit alliance of patients...
limited to acquired blood clots, genetic thrombophilia, and paroxysmal nocturnal hemoglobinuria. Genetic thrombophilia can coexist in some patients with APS...
women with thrombophilia go through one or more pregnancies with no difficulties, while others may have pregnancy complications. Thrombophilia may explain...
(January 2017). "The use of direct oral anticoagulants in inherited thrombophilia". Journal of Thrombosis and Thrombolysis. 43 (1): 24–30. doi:10.1007/s11239-016-1428-2...
main causes of thrombosis are given in Virchow's triad which lists thrombophilia, endothelial cell injury, and disturbed blood flow. Generally speaking...
protein hyperfunctional and is associated with familial early-onset thrombophilia. Factor IX deficiency is treated by injection of purified factor IX...
apolipoprotein C2, may also be lost by increased filtration of proteins. Thrombophilia, or hypercoagulability, is a greater predisposition for the formation...
result in coagulopathy (bleeding disorders). Hypercoagulable state (thrombophilia) results from defects in regulation of platelet or clotting factor function...
hypertrophy, dysrhythmia, P pulmonale (characteristic peaked P wave) Thrombophilia screen- to detect chronic venous thromboembolism (proteins C and S,...
factors, such as surgery and immobilization, appear to dominate, whereas thrombophilias and age do not seem to increase risk. Common risk factors for having...
situations. 85% of people have at least one of these risk factors: Thrombophilia, a tendency to develop blood clots due to abnormalities in coagulation...
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