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intrinsic component of external side of plasma membrane
plasma membrane
extracellular region
extracellular exosome
cell surface
extracellular space
serine-type peptidase complex
integral component of membrane
collagen-containing extracellular matrix
Biological process
hemostasis
positive regulation of protein kinase B signaling
positive regulation of endothelial cell proliferation
cytokine-mediated signaling pathway
positive regulation of cell migration
activation of blood coagulation via clotting cascade
positive regulation of platelet-derived growth factor receptor signaling pathway
positive regulation of angiogenesis
blood coagulation, extrinsic pathway
activation of plasma proteins involved in acute inflammatory response
activation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of positive chemotaxis
blood coagulation
protein processing
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
2152
14066
Ensembl
ENSG00000117525
ENSMUSG00000028128
UniProt
P13726
P20352
RefSeq (mRNA)
NM_001993 NM_001178096
NM_010171
RefSeq (protein)
NP_001171567 NP_001984
NP_034301
Location (UCSC)
Chr 1: 94.53 – 94.54 Mb
Chr 3: 121.52 – 121.53 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Tissue factor, also called platelet tissue factor, coagulation factor III, or CD142, is a protein encoded by the F3 gene, present in subendothelial tissue and leukocytes. Its role in the clotting process is the initiation of thrombin formation from the zymogen prothrombin. Thromboplastin defines the cascade that leads to the activation of factor X—the tissue factor pathway. In doing so, it has replaced the previously named extrinsic pathway in order to eliminate ambiguity.
^ abcGRCh38: Ensembl release 89: ENSG00000117525 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000028128 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Tissuefactor, also called platelet tissuefactor, coagulation factor III, or CD142, is a protein encoded by the F3 gene, present in subendothelial tissue...
in platelets, and the exposure of subendothelial platelet tissuefactor to coagulation factor VII, which ultimately leads to cross-linked fibrin formation...
Tissuefactor pathway inhibitor (or TFPI) is a single-chain polypeptide which can reversibly inhibit factor Xa (Xa). While Xa is inhibited, the Xa-TFPI...
to tissuefactor released from damaged tissues, it is converted to factor VIIa (or blood-coagulation factor VIIa, activated blood coagulation factor VII)...
factor IX (with its cofactor, factor VIII in a complex known as intrinsic tenase) and factor VII with its cofactor, tissuefactor (a complex known as extrinsic...
both phospholipids and tissuefactor, neither of which are enzymes. Thromboplastin acts on and accelerates the activity of Factor Xa, also known as thrombokinase...
peptide, glycosylated and then cleaved by factor XIa (of the contact pathway) or factor VIIa (of the tissuefactor pathway) to produce a two-chain form, where...
factor from damaged tissue. Tissuefactor binds to circulating factor VIIa. The combination activates factor X to factor Xa and factor IX to factor IXa...
platelets contain cytokines and growth factors which can promote wound healing and regeneration of damaged tissues. Structurally the platelet can be divided...
the whole body or for individual organs. 2. The tissue weighting factor WT, which is specific for tissue type T being irradiated. This is used with WR to...
Adipose tissue (also known as body fat or simply fat) is a loose connective tissue composed mostly of adipocytes. It also contains the stromal vascular...
damage host tissue. Factor H regulates complement activation on self cells and surfaces by possessing both cofactor activity for Factor I–mediated C3b...
that are formed from catechins in tea leaves Tissuefactor, or tissuefactor gene Transcription factor, a protein that binds to specific DNA sequences...
monocytes to release tissuefactor. Monocytes are also recruited early in the process. Tissuefactor, via the tissuefactor–factor VIIa complex, activates...
wounds. Saliva contains tissuefactor which promotes the blood clotting mechanism. The enzyme lysozyme is found in many tissues and is known to attack...
cancer. It is a combination of tisotumab, a monoclonal antibody against tissuefactor, and monomethyl auristatin E (MMAE), a potent inhibitor of cell division...
coagulation cascade. After a trauma factor VII initiates the process of coagulation in conjunction with tissuefactor (TF/factor III) in the extrinsic pathway...
not uncommon. Many trauma patients have an overwhelming activation of tissuefactor and thus massive hyperfibrinolysis. Hyperfibrinolysis may occur in other...
activates its substrate (inactive factor X) by cleaving it. Extrinsic tenase complex is made up of tissuefactor, factor VII, and Ca2+ as an activating ion...
vessels, exposing the enzyme called factor VII, a protein normally circulating within the vessels, to the tissuefactor, which is a protein encoded by the F3 gene...
the founders of modern pathology. Necrosis is caused by factors external to the cell or tissue, such as infection, or trauma which result in the unregulated...
nature. Some connective tissue diseases have strong or weak genetic inheritance risks. Others may be due to environmental factors, or a combination of genetic...
to a living organism's replacement of destroyed or damaged tissue by newly produced tissue. In undamaged skin, the epidermis (surface, epithelial layer)...
monoclonal antibody used for the treatment of hemophilia B. It is an anti-tissuefactor pathway inhibitor. Concizumab was approved for medical use in Canada...
endothelial lining of the vessel's wall. The main mechanism is exposure of tissuefactor to the blood coagulation system. Inflammatory and other stimuli (such...
biochemical and physicochemical factors to restore, maintain, improve, or replace different types of biological tissues. Tissue engineering often involves...
CTGF, also known as CCN2 or connective tissue growth factor, is a matricellular protein of the CCN family of extracellular matrix-associated heparin-binding...
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