endoplasmic reticulum to Golgi vesicle-mediated transport
signal peptide processing
blood coagulation, extrinsic pathway
peptidyl-glutamic acid carboxylation
proteolysis
blood coagulation
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
2158
14071
Ensembl
ENSG00000101981
ENSMUSG00000031138
UniProt
P00740
P16294
RefSeq (mRNA)
NM_000133 NM_001313913
NM_007979 NM_001305797
RefSeq (protein)
NP_000124 NP_001300842
NP_001292726 NP_032005
Location (UCSC)
Chr X: 139.53 – 139.56 Mb
Chr X: 59.04 – 59.08 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Factor IX (or Christmas factor) (EC 3.4.21.22) is one of the serine proteases of the coagulation system; it belongs to peptidase family S1. Deficiency of this protein causes haemophilia B. It was discovered in 1952 after a young boy named Stephen Christmas was found to be lacking this exact factor, leading to haemophilia.[5]
Coagulation factor IX is on the World Health Organization's List of Essential Medicines.[6]
^ abcGRCh38: Ensembl release 89: ENSG00000101981 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000031138 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Biggs R, Douglas AS, Macfarlane RG, Dacie JV, Pitney WR (Dec 1952). "Christmas disease: a condition previously mistaken for haemophilia". British Medical Journal. 2 (4799): 1378–82. doi:10.1136/bmj.2.4799.1378. PMC 2022306. PMID 12997790.
^World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
FactorIX (or Christmas factor) (EC 3.4.21.22) is one of the serine proteases of the coagulation system; it belongs to peptidase family S1. Deficiency...
inherited mutation of the gene for factorIX, and resulting in a deficiency of factorIX. It is less common than factor VIII deficiency (haemophilia A)....
known as factorIX complex, sold under the brand name Kcentra among others, is a combination medication made up of blood clotting factors II, IX, and X...
Willebrand factor (vWF), which is released from the endothelium and from platelets; vWF forms additional links between the platelets' glycoprotein Ib/IX/V and...
Willebrand factor. The active protein (sometimes written as coagulation factor VIIIa) interacts with another coagulation factor called factorIX. This interaction...
Factor X is synthesized in the liver and requires vitamin K for its synthesis. Factor X is activated, by hydrolysis, into factor Xa by both factorIX...
coagulation factor VII), which in turn activates factorIX and factor X. Using genetic recombination a recombinant factor VIIa (eptacog alfa) (trade names include...
occurs due to low amounts of clotting factor VIII, and haemophilia B, which occurs due to low levels of clotting factorIX. They are typically inherited from...
deficient in Factor II, Factor VII, FactorIX, and Factor X. Aged plasma is deficient in Factor V & Factor VIIIC. Serum is deficient in factors I, V & VIIIC...
adeno-associated virus used for the treatment of Hemophilia B (congenital FactorIX deficiency). It was approved for medical use in Canada in December 2023...
sequence of the RNA for FactorIX by examining the amino acids in FactorIX: Microsequencing of highly purified... [FactorIX] yielded sufficient amino...
activated coagulation factorIX and to factor X, mediating the activation of the latter. This is normally the function of coagulation factor VIII, which is missing...
human diseases. The protein in question was the human blood clotting factorIX. Another difference from Dolly the Sheep was the source cell type of the...
Intrinsic tenase complex contains the active factorIX (IXa), its cofactor factor VIII (VIIIa), the substrate (factor X), and they are activated by negatively...
levels of active clotting factor. Two of the most common differential diagnoses are haemophilia B which is a deficiency in FactorIX and von Willebrand Disease...
Financial Reporting, a financial reporting software application FactorIX, a coagulation factor F9, a function key on a computer keyboard Zeolite F-9, a sodium-type...
activated factorIX and factor VIII. Both pathways lead to the activation of factor X (the common pathway), which combines with activated factor V in the...
factor VIII concentrate Berinin P, freeze-dried human coagulation factorIX concentrate Factor X P Behring, a freeze-dried human coagulation factor IX...
deficiency of Factor VIII causes classic hemophilia A while deficiencies of FactorIX cause "Christmas disease"(hemophilia B). Antibodies to Factor VIII can...
factor from damaged tissue. Tissue factor binds to circulating factor VIIa. The combination activates factor X to factor Xa and factorIX to factor IXa...
HIV, as a result of receiving contaminated blood or contaminated clotting factor products. Many of the products were imported from the US, and distributed...
Title IX is the most commonly used name for the landmark federal civil rights law in the United States that was enacted as part (Title IX) of the Education...
dealing with the controversy surrounding Anastasia's death. Hemophilia B (FactorIX Deficiency) Could the Bulgarian mountain village of Gabarevo be the last...
Global Information
