structure of the rb c-terminal domain bound to an e2f1-dp1 heterodimer
Identifiers
Symbol
DP
Pfam
PF08781
InterPro
IPR014889
PROSITE
PDOC00359
MEROPS
S9
SCOP2
1c5e / SCOPe / SUPFAM
CAZy
GT1
Available protein structures:
Pfam
structures / ECOD
PDB
RCSB PDB; PDBe; PDBj
PDBsum
structure summary
In molecular biology, transcription factor DP (Dimerization Partner) is a family of proteins which function as transcription factors.
DP forms a heterodimer with E2F and regulates genes involved in cell cycle progression. The transcriptional activity of E2F is inhibited by the retinoblastoma protein which binds to the E2F-DP heterodimer [1] and negatively regulates the G1-S transition.
^Rubin SM, Gall AL, Zheng N, Pavletich NP (December 2005). "Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release". Cell. 123 (6): 1093–106. doi:10.1016/j.cell.2005.09.044. PMID 16360038. S2CID 6158027.
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