The dimerization partner, RB-like, E2F and multi-vulval class B (DREAM) complex is a protein complex responsible for the regulation of cell cycle-dependent gene expression.[1][2] The complex is evolutionarily conserved, although some of its components vary from species to species. In humans, the key proteins in the complex are RBL1 (p107) and RBL2 (p130), both of which are homologs of RB (p105) and bind repressive E2F transcription factors E2F4 and E2F5; DP1, DP2 and DP3, dimerization partners of E2F; and MuvB, which is a complex of LIN9/37/52/54 and RBBP4.[1]
^ abSadasivam, Subhashini; DeCaprio, James A. (11 July 2013). "The DREAM complex: master coordinator of cell cycle-dependent gene expression". Nature Reviews Cancer. 13 (8): 585–595. doi:10.1038/nrc3556. PMC 3986830. PMID 23842645.
^Fischer, M; Müller, GA (December 2017). "Cell cycle transcription control: DREAM/MuvB and RB-E2F complexes". Critical Reviews in Biochemistry and Molecular Biology. 52 (6): 638–662. doi:10.1080/10409238.2017.1360836. PMID 28799433. S2CID 205695213.
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