In biology, a Src homology domain is one of the two small protein binding domains found in the Src oncoprotein. Homologs of both the Src homology 2 and Src homology 3 domains are found in numerous other proteins. The Src homology 1 domain was an early name of the protein kinase domain.
In terms of initiating the cell cycle when growth factor signals are present, "Src homology domains" are found on Grb2 proteins, allowing them to bind Receptor Tyrosine Kinases (RTKs), and also on SOS proteins allowing them to interact with Grb2. This brings SOS proteins close to the membrane, where Ras-GDP is bound via a lipid "tail". SOS acts as a Guanosine exchange factor (GEF) for Ras, activating Ras to cleave a phosphate group from Raf, causing it to release the 14-3-3 proteins that are keeping it inactive, which through a downstream signalling cascade allows the release of E2F and thus, progression through the Restriction point (R point) in G1 phase of the cell cycle.
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and 24 Related for: Src homology domain information
a Srchomologydomain is one of the two small protein binding domains found in the Src oncoprotein. Homologs of both the Srchomology 2 and Src homology...
The SH2 (SrcHomology 2) domain is a structurally conserved protein domain contained within the Src oncoprotein and in many other intracellular signal-transducing...
The SRCHomology 3 Domain (or SH3 domain) is a small protein domain of about 60 amino acid residues. Initially, SH3 was described as a conserved sequence...
Srchomology 2 domain containing F is a protein that in humans is encoded by the SHF gene. GRCh38: Ensembl release 89: ENSG00000138606 – Ensembl, May...
phosphatase-like 1, a protein that in addition to the phosphatase domain contains an SH2 (src-homologydomain 2) motif. INPPL1 has been shown to interact with: BCAR1...
phosphorylates the membrane adaptor Lat, which subsequently recruits several Srchomologydomain–containing proteins, including phospholipase C-γ1 (PLC-γ1) activation...
"5-Lipoxygenase contains a functional Srchomology 3-binding motif that interacts with the Srchomology 3 domain of Grb2 and cytoskeletal proteins". The...
Tyrosine-protein phosphatase non-receptor type 6, also known as Srchomology region 2 domain-containing phosphatase-1 (SHP-1), is an enzyme that in humans...
"Gene expression of Sh3d19, a novel adaptor protein with five Srchomology 3 domains, in anagen mouse hair follicles". Journal of Dermatological Science...
(August 1998). "Sequences surrounding the Src-homology 3 domain of phospholipase Cgamma-1 increase the domain's association with Cbl". Biochemical and Biophysical...
trk proto-oncogene product and stimulates its association with the srchomologydomain of phospholipase C gamma 1" (PDF). Biochemical and Biophysical Research...
(August 1998). "Sequences surrounding the Src-homology 3 domain of phospholipase Cgamma-1 increase the domain's association with Cbl". Biochem. Biophys...
compartments. Inhibitory NKG2 molecules containing ITIMs recruite the Srchomology 2 domain containing phosphatases SHP-1 and SHP-2, which leads to the inhibition...
including the actin-binding protein profilin, SH3 (Srchomology 3) domain proteins, and WW domain proteins. The actin nucleation-promoting activity of...
Adaptor proteins usually contain several domains within their structure (e.g., Srchomology 2 (SH2) and SH3 domains) that allow specific interactions with...
SGEF (Srchomology 3 domain-containing Guanine nucleotide Exchange Factor) is a 97 kDa protein involved in intracellular signalling networks. It functions...
or membrane trafficking. Srchomology 2 domain (SH2): SH2 domains are often found in signal transduction proteins. SH2 domains confer binding to phosphorylated...
(PTPN11) also known as protein-tyrosine phosphatase 1D (PTP-1D), Srchomology region 2 domain-containing phosphatase-2 (SHP-2), or protein-tyrosine phosphatase...
the GTPase domain and terminates with a Proline Rich Domain that binds to the SrcHomologydomains of many proteins. During clathrin-mediated endocytosis...
2003). "Functional requirements for interactions between CD84 and Srchomology 2 domain-containing proteins and their contribution to human T cell activation"...
lack of Srchomology binding domains (SH2/SH3) and the presence of up to seven JAK homologydomains (JH1-JH7). Nonetheless the terminal JH domains retain...
the SH2 (Srchomology) domain, which is a region that has phosphotyrosine receptors and is important in many signaling molecules. This domain is located...
of the JH1 domain which has undergone mutation post-duplication. The JH3-JH4 domains of JAKs share homology with Src-homology-2 (SH2) domains. The amino...
SHC may refer to: Srchomology 2 domain-containing, in structural biology, a structural domain in signal transduction proteins SHC1, a human gene Sirohydrochlorin...
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