Dopaminergic cell groups, DA cell groups, or dopaminergic nuclei are collections of neurons in the central nervous system that synthesize the neurotransmitter dopamine.[1] In the 1960s, dopaminergic neurons or dopamine neurons were first identified and named by Annica Dahlström and Kjell Fuxe, who used histochemical fluorescence.[2] The subsequent discovery of genes encoding enzymes that synthesize dopamine, and transporters that incorporate dopamine into synaptic vesicles or reclaim it after synaptic release, enabled scientists to identify dopaminergic neurons by labeling gene or protein expression that is specific to these neurons.
In the mammalian brain, dopaminergic neurons form a semi-continuous population extending from the midbrain through the forebrain, with eleven named collections or clusters among them.[3][4][5]
^"Dopaminergic cell groups". braininfo.rprc.washington.edu. Retrieved 8 August 2022.
^Fuxe, Hoekfelt & Ungerstedt (1970).
^Smeets & Reiner (1994).
^Felten & Sladek Jr (1983).
^Dubach (1994).
and 27 Related for: Dopaminergic cell groups information
Dopaminergiccellgroups, DA cellgroups, or dopaminergic nuclei are collections of neurons in the central nervous system that synthesize the neurotransmitter...
Dopaminergic pathways (dopamine pathways, dopaminergic projections) in the human brain are involved in both physiological and behavioral processes including...
The dopaminergiccellgroups and pathways make up the dopamine system which is neuromodulatory. Dopaminergic neurons (dopamine-producing nerve cells) are...
combination of dopaminergiccellgroups and noradrenergic cellgroups. Some authors include in this category 'putative' adrenergic cellgroups, collections...
specific sensory stimuli for example during sexual behaviour. Dopaminergiccellgroups Giuliano, F; Allard (August 2001). "Dopamine and sexual function"...
code AAQ Eastern Abenaki language, ISO 939-3 language code aaq Dopaminergiccellgroup Aaq the Swiss Agency of Accreditation and Quality Assurance (AAQ)...
monoaminergic cellgroups in the macaque and the squirrel monkey did not identify a B4 cellgroup distinct from other groups in the region. Cellgroup B5 is located...
tegmentum, is a group of neurons located close to the midline on the floor of the midbrain. The VTA is the origin of the dopaminergiccell bodies of the...
may be termed by their associated neurotransmitter such as excitatory dopaminergic neurons and inhibitory GABAergic neurons. Cortical interneurons only...
Parkinson's disease is characterized by the death of dopaminergic neurons in this region. In humans, the nerve cell bodies of the pars compacta are coloured black...
the pars reticulata (SNr). The pars compacta contains dopaminergic neurons from the A9 cellgroup that forms the nigrostriatal pathway that, by supplying...
synaptic neuron and cell damage. Glutamate is synthesized from the amino acid glutamine by the enzyme glutamate synthase. Dopaminergic neurons—dopamine....
indicate that iPSCs, like hESCs, may be differentiable into dopaminergic neurons. Stem cell-associated genes were downregulated after differentiation....
4-Dihydroxyphenylacetaldehyde (DOPAL), is a potent inducer of programmed cell death (apoptosis) in dopaminergic neurons. DOPAL may play an important role in the pathology...
thiol group in the globin protein, releasing it at the same time as oxygen. Hemoglobin is also found in other cells, including in the A9 dopaminergic neurons...
high levels of neuromelanin in dopaminergic neurons. Parkinson's disease is characterized by the loss of dopaminergic neurons in the substantia nigra...
mitochondrion (/ˌmaɪtəˈkɒndriən/; pl.: mitochondria) is an organelle found in the cells of most eukaryotes, such as animals, plants and fungi. Mitochondria have...
synthetic organic compound used by researchers to selectively destroy dopaminergic and noradrenergic neurons in the brain. The main use for oxidopamine...
mesolimbic pathway, sometimes referred to as the reward pathway, is a dopaminergic pathway in the brain. The pathway connects the ventral tegmental area...
"star" and κύτος, kútos, "cavity", "cell"), also known collectively as astroglia, are characteristic star-shaped glial cells in the brain and spinal cord. They...
Ernest (2020). "Midbrain Dopaminergic Neuron Development at the Single Cell Level: In vivo and in Stem Cells". Frontiers in Cell and Developmental Biology...
neural lineage cells. An example of the therapeutic usage of this technique is the targeted differentiation of ventral midbrain dopaminergic (DAergenic)...
peripheral cell types. These include cell receptors in the arcuate and ventromedial nuclei, as well as other parts of the hypothalamus and dopaminergic neurons...
that photostimulation of genetically circumscribed groups of neurons, such as those of the dopaminergic system, elicited characteristic behavioural changes...
been shown to affect the dopaminergic neuronal cell lines N27 by disrupting the mitochondrial dynamics. Loss of dopaminergiccells have been linked to Parkinson's...
wake-promoting cellgroups such as the HA cells of the TM,101 the 5-HT cells of the dorsal Raphe nuclei (DRN),101 the noradrenergic cells of the LC,102...