Precursor cells of neurons and glia during embryonic development
Neural stem cell
Details
System
Nervous system
Identifiers
Latin
cellula nervosa praecursoria
MeSH
D058953
TH
H2.00.01.0.00010
FMA
86684
Anatomical terms of microanatomy
[edit on Wikidata]
Neural stem cells (NSCs) are self-renewing, multipotent cells that firstly generate the radial glial progenitor cells that generate the neurons and glia of the nervous system of all animals during embryonic development.[1] Some neural progenitor stem cells persist in highly restricted regions in the adult vertebrate brain and continue to produce neurons throughout life. Differences in the size of the central nervous system are among the most important distinctions between the species and thus mutations in the genes that regulate the size of the neural stem cell compartment are among the most important drivers of vertebrate evolution. [2]
Stem cells are characterized by their capacity to differentiate into multiple cell types.[3] They undergo symmetric or asymmetric cell division into two daughter cells. In symmetric cell division, both daughter cells are also stem cells. In asymmetric division, a stem cell produces one stem cell and one specialized cell.[4] NSCs primarily differentiate into neurons, astrocytes, and oligodendrocytes.
^Gilbert, Scott F.; College, Swarthmore; Helsinki, the University of (2014). Developmental biology (Tenth ed.). Sunderland, Mass.: Sinauer. ISBN 978-0878939787.
Neuralstemcells (NSCs) are self-renewing, multipotent cells that firstly generate the radial glial progenitor cells that generate the neurons and glia...
multicellular organisms, stemcells are undifferentiated or partially differentiated cells that can change into various types of cells and proliferate indefinitely...
Adult stemcells are undifferentiated cells, found throughout the body after development, that multiply by cell division to replenish dying cells and regenerate...
neuron, neurone, or nerve cell is an electrically excitable cell that fires electric signals called action potentials across a neural network. Neurons communicate...
Cancer stemcells (CSCs) are cancer cells (found within tumors or hematological cancers) that possess characteristics associated with normal stemcells, specifically...
Neuroepithelial cells are the stemcells of the central nervous system, known as neuralstemcells, and generate the intermediate progenitor cells known as radial...
Mouthon MA (2008). "Role of Fanconi DNA repair pathway in neuralstemcell homeostasis". Cell Cycle. 7 (13): 1911–5. doi:10.4161/cc.7.13.6235. PMID 18604174...
Stemcell markers are genes and their protein products used by scientists to isolate and identify stemcells. Stemcells can also be identified by functional...
neuralstemcell to granule cell in the SGZ can be described by tracing the following lineage of cell types: Radial glial cells. Radial glial cells are...
multipotent neuralstemcells. Gliogenesis results in the formation of non-neuronal glia populations from neuronal cells. In this capacity, glial cells provide...
of undifferentiated embryonic stemcells. Sox2 has a critical role in maintenance of embryonic and neuralstemcells. Sox2 is a member of the Sox family...
fate of a stemcell can be best understood by knowing the "circuitry employed to orchestrate stemcell maintenance and progressive neural fate decisions"...
Albany, New York. She is a co-founder and scientific director for The NeuralStemCell Institute and is a professor of Neuroscience and Neuropharmacology...
radial glial cells and are committed to becoming neurons. Neuralstemcells, which only divide symmetrically to produce more neuralstemcells, transition...
Depending on the goal of a particular study, one can use neuralstemcells markers, neural progenitor cell markers, neuron markers or PNS neuronal markers. The...
transplanting T-cells capable of fighting cancer cells via cell-mediated immunity in the course of immunotherapy, or grafting stemcells to regenerate diseased...
A progenitor cell is a biological cell that can differentiate into a specific cell type. Stemcells and progenitor cells have this ability in common....
Neurogenesis is the process by which nervous system cells, the neurons, are produced by neuralstemcells (NSCs). In short, it is brain growth in relation...
pluripotent stemcells (also known as iPS cells or iPSCs) are a type of pluripotent stemcell that can be generated directly from a somatic cell. The iPSC...
Neural crest cells are a temporary group of cells that arise from the embryonic ectoderm germ layer, and in turn give rise to a diverse cell lineage—including...
revealed that cells may differentiate not into a fully totipotent cell, but instead into a "complex cellular variation" of totipotency. Stemcells resembling...
cells. Examples of stem and progenitor cells include:[citation needed] Radial glial cells (embryonic neuralstemcells) that give rise to excitatory neurons...
but later, these stemcells begin to generate neurons through the process of neurogenesis. NeuralstemcellStemcell Radial glial cell Neurogenesis Cellular...
Induced stemcells (iSC) are stemcells derived from somatic, reproductive, pluripotent or other cell types by deliberate epigenetic reprogramming. They...
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