protein serine/threonine kinase activator activity
Cellular component
nucleoplasm
nucleus
nuclear body
Dbf4-dependent protein kinase complex
Biological process
DNA replication
cell cycle
positive regulation of catalytic activity
G1/S transition of mitotic cell cycle
positive regulation of DNA replication
positive regulation of protein serine/threonine kinase activity
positive regulation of nuclear cell cycle DNA replication
regulation of cell cycle phase transition
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
10926
27214
Ensembl
ENSG00000006634
ENSMUSG00000002297
UniProt
Q9UBU7
Q9QZ41
RefSeq (mRNA)
NM_006716 NM_001318060 NM_001318061 NM_001318062
NM_001190717 NM_013726
RefSeq (protein)
NP_001304989 NP_001304990 NP_001304991 NP_006707
NP_001177646 NP_038754
Location (UCSC)
Chr 7: 87.88 – 87.91 Mb
Chr 5: 8.45 – 8.47 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Protein DBF4 homolog A is a protein that is encoded by the DBF4 gene in humans.[5][6][7]
^ abcGRCh38: Ensembl release 89: ENSG00000006634 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000002297 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Kumagai H, Sato N, Yamada M, Mahony D, Seghezzi W, Lees E, Arai K, Masai H (Jul 1999). "A novel growth- and cell cycle-regulated protein, ASK, activates human Cdc7-related kinase and is essential for G1/S transition in mammalian cells". Molecular and Cellular Biology. 19 (7): 5083–95. doi:10.1128/MCB.19.7.5083. PMC 84351. PMID 10373557.
^Lepke M, Pütter V, Staib C, Kneissl M, Berger C, Hoehn K, Nanda I, Schmid M, Grummt F (Sep 1999). "Identification, characterization and chromosomal localization of the cognate human and murine DBF4 genes". Molecular & General Genetics. 262 (2): 220–9. doi:10.1007/s004380051078. PMID 10517317. S2CID 24878962.
^"Entrez Gene: DBF4 DBF4 homolog (S. cerevisiae)".
Protein DBF4 homolog A is a protein that is encoded by the DBF4 gene in humans. DBF4 has been shown to interact with: Cell division cycle 7-related protein...
Dysdiadochokinesia, a type of cerebellar ataxia In molecular biology, Cdc7/Dbf4 kinase, or Dbf4-dependent kinase, — protein kinase required for initiation of eukaryotic...
complex is triggered by two kinases, cyclin-dependent kinase 2 (CDK) and Dbf4-dependent kinase (DDK) that help transition the pre-RC to the initiation...
ed6c66e2-82c2-4797-a771-0d83a37058cd Observation.org: 188752 Open Tree of Life: 676506 ScaleNet: Icerya purchasi ZooBank: CCB22C51-DBF4-4D3D-B686-B371C9498FC6...
ed6c66e2-82c2-4797-a771-0d83a37058cd Observation.org: 188752 Open Tree of Life: 676506 ScaleNet: Icerya purchasi ZooBank: CCB22C51-DBF4-4D3D-B686-B371C9498FC6...
NBN: NBNSYS0000131371 NCBI: 170894 Open Tree of Life: 825503 Plazi: 3B4C4DAD-F9A9-1758-F20B-1B9228C4093B ZooBank: 7E4BCA1B-DBF4-467E-BC28-383B7DD0F764...
activity rises abruptly as a result of association with the regulatory subunit DBF4, which binds Cdc7 directly and promotes its protein kinase activity. Cdc7...
as a head-to-head double hexamer onto DNA to license origins. In S-phase, Dbf4-dependent kinase (DDK) and Cyclin-dependent kinase (CDK) phosphorylate several...
S2CID 15691580. Tsuji T, Lau E, Chiang GG, Jiang W (December 2008). "The role of Dbf4/Drf1-dependent kinase Cdc7 in DNA-damage checkpoint control". Molecular Cell...
induction in A2-4 cells, the target DNA replication factor proteins—MCMs, RPA34, DBF4, RFCp37, and RFCp140—all showed decreased levels. Along with decreased levels...
(pre-RC). Pre-RC triggered to initiate when cyclin-dependent kinase (CDK) and Dbf4-dependent kinase (DDK) bind to it. Initiation complexes then allow for recruitment...
Kihara, M., Sugino, A. & Tye, B. K. Mcm2 is a target of regulation by Cdc7-Dbf4 during the initiation of DNA synthesis. Genes Dev 11, 3365-3374 (1997). Homesley...
PSIP1 has been shown to interact with the proteins ASF/SF2, JPO2, Cdc7-Dbf4, and POGZ as well as the menin/MLL protein complex. GRCh38: Ensembl release...
has been shown to interact with MCM5, ORC2, Replication protein A1, ORC4, DBF4, ORC3, CDC45-related protein, MCM4 and Cell division cycle 7-related protein...
conserved S-phase replication start enzyme Cdc7, its activating protein Dbf4, and a number of other components. The H3T45 residue appears to be a nucleosome...
S2CID 8689588. Jiang W, McDonald D, Hope TJ, Hunter T (Oct 1999). "Mammalian Cdc7-Dbf4 protein kinase complex is essential for initiation of DNA replication". The...
Dbf4 is the key regulator of Cdc7 activity – association Cdc7 with Dbf4 activates its kinase activity. In a similar manner to cyclin levels, dbf4 levels...
PMID 9765232. Jiang W, McDonald D, Hope TJ, Hunter T (Oct 1999). "Mammalian Cdc7-Dbf4 protein kinase complex is essential for initiation of DNA replication". The...
DNA replication. Upon entry into S phase, the activity of the CDKs and the Dbf4-dependent kinase (DDK) Cdc7 promotes the assembly of replication forks, likely...
Zachariae W (March 2010). "Rec8 phosphorylation by casein kinase 1 and Cdc7-Dbf4 kinase regulates cohesin cleavage by separase during meiosis". Developmental...
progression. MCM3 has been shown to interact with: CDC45-related protein, CDC6, DBF4, MCM2 MCM3AP, MCM5, MCM7, ORC4L, and ORC5L. Mini Chromosome Maintenance GRCh38:...
PMID 10438470. Jiang W, McDonald D, Hope TJ, Hunter T (Oct 1999). "Mammalian Cdc7-Dbf4 protein kinase complex is essential for initiation of DNA replication". The...
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