PSIP1 information

PSIP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1Z9E, 2B4J, 2M16, 2MSR, 2MTN, 2N3A, 3F9K, 3HPG, 3HPH, 3U88, 3ZEH, 4FU6
Identifiers
Aliases	PSIP1, DFS70, LEDGF, PAIP, PSIP2, p52, p75, PC4 and SFRS1 interacting protein 1
External IDs	OMIM: 603620 MGI: 2142116 HomoloGene: 13242 GeneCards: PSIP1
Gene location (Human)
Chr.	Chromosome 9 (human)
End	15,510,995 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	83,404,696 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; ganglionic eminence; ; cerebellar hemisphere; ; Brodmann area 9; ; Achilles tendon; ; optic nerve; ; nucleus accumbens; ; prefrontal cortex; ; caudate nucleus; ; amygdala;
	Top expressed in
	spermatocyte; ; ganglionic eminence; ; secondary oocyte; ; abdominal wall; ; dorsomedial hypothalamic nucleus; ; olfactory tubercle; ; maxillary prominence; ; nucleus accumbens; ; cerebellar cortex; ; mammillary body;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; transcription coactivator activity; chromatin binding; protein binding; supercoiled DNA binding; RNA binding;
Cellular component	cytosol; nuclear periphery; nucleoplasm; nucleolus; nucleus;
Biological process	regulation of transcription, DNA-templated; response to heat; response to oxidative stress; transcription, DNA-templated; establishment of integrated proviral latency; mRNA 5'-splice site recognition; positive regulation of transcription by RNA polymerase II; viral process; nuclear transport;
	Sources:Amigo / QuickGO
Orthologs
	11168
	101739
	ENSG00000164985
	ENSMUSG00000028484
	O75475
	Q99JF8
	NM_001128217; NM_021144; NM_033222; NM_001317898; NM_001317900
	NM_001290527; NM_133948; NM_001347143; NM_001355203
	NP_001121689; NP_001304827; NP_001304829; NP_066967; NP_150091
	NP_001277456; NP_001334072; NP_598709; NP_001342132
	Wikidata
View/Edit Human	View/Edit Mouse

PC4 and SFRS1 interacting protein 1, also known as lens epithelium-derived growth factor (LEDGF/p75), dense fine speckles 70kD protein (DFS 70) or transcriptional coactivator p75/p52, is a protein that in humans is encoded by the PSIP1 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000164985 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028484 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: PSIP1 PC4 and SFRS1 interacting protein 1".
^ Singh DP, Kimura A, Chylack LT, Shinohara T (January 2000). "Lens epithelium-derived growth factor (LEDGF/p75) and p52 are derived from a single gene by alternative splicing". Gene. 242 (1–2): 265–73. doi:10.1016/S0378-1119(99)00506-5. PMID 10721720.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000164985 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028484 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: PSIP1 PC4 and SFRS1 interacting protein 1".

[pmid10721720-6] Singh DP, Kimura A, Chylack LT, Shinohara T (January 2000). "Lens epithelium-derived growth factor (LEDGF/p75) and p52 are derived from a single gene by alternative splicing". Gene. 242 (1–2): 265–73. doi:10.1016/S0378-1119(99)00506-5. PMID 10721720.

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