The minichromosome maintenance protein complex (MCM) is a DNA helicase essential for genomic DNA replication. Eukaryotic MCM consists of six gene products, Mcm2–7, which form a heterohexamer.[1][2] As a critical protein for cell division, MCM is also the target of various checkpoint pathways, such as the S-phase entry and S-phase arrest checkpoints. Both the loading and activation of MCM helicase are strictly regulated and are coupled to cell growth cycles. Deregulation of MCM function has been linked to genomic instability and a variety of carcinomas.[3][4]
^ abLi N, Zhai Y, Zhang Y, Li W, Yang M, Lei J, Tye BK, Gao N (August 2015). "Structure of the eukaryotic MCM complex at 3.8 Å". Nature. 524 (7564): 186–91. Bibcode:2015Natur.524..186L. doi:10.1038/nature14685. PMID 26222030. S2CID 4468690.
^Zhai Y, Cheng E, Wu H, Li N, Yung PY, Gao N, Tye BK (March 2017). "Open-ringed structure of the Cdt1-Mcm2-7 complex as a precursor of the MCM double hexamer". Nature Structural & Molecular Biology. 24 (3): 300–308. doi:10.1038/nsmb.3374. PMID 28191894. S2CID 3929807.
^Bochman ML, Schwacha A (December 2009). "The Mcm complex: unwinding the mechanism of a replicative helicase". Microbiology and Molecular Biology Reviews. 73 (4): 652–83. doi:10.1128/mmbr.00019-09. PMC 2786579. PMID 19946136.
^Shima N, Alcaraz A, Liachko I, Buske TR, Andrews CA, Munroe RJ, Hartford SA, Tye BK, Schimenti JC (January 2007). "A viable allele of Mcm4 causes chromosome instability and mammary adenocarcinomas in mice". Nature Genetics. 39 (1): 93–8. doi:10.1038/ng1936. PMID 17143284. S2CID 11433033.
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The minichromosomemaintenance protein complex (MCM) is a DNA helicase essential for genomic DNA replication. Eukaryotic MCM consists of six gene products...
cycle 6 protein (Cdc6) to form a platform for the loading of the minichromosomemaintenance (Mcm 2–7) complex proteins, facilitated by the chromatin licensing...
A minichromosome is a small chromatin-like structure resembling a chromosome and consisting of centromeres, telomeres and replication origins but little...
each other. Since both regions of Orc1/Cdc6 associate with a minichromosomemaintenance (MCM) replicative helicase, this specific arrangement of ORB elements...
pre-replicative complex (pre-RC) and is required for loading minichromosomemaintenance (MCM) proteins onto the DNA, an essential step in the initiation...
protein CDC6, are then recruited to the forming pre-RC, followed by minichromosomemaintenance complexes (MCM2-7). The activity of CDT1 during the cell cycle...
from the effects of a chemical, biological, or nuclear attack Minichromosomemaintenance protein, which forms DNA helicase in eukaryotic species Mobil...
work on eukaryotic DNA replication led to the discovery of the minichromosomemaintenance (MCM) genes in 1984, which encode the catalytic core of the eukaryotic...
hydrolysis. In eukaryotes, helicase function is provided by the MCM (Minichromosomemaintenance) complex. The DnaB helicase is the product of the dnaB gene. The...
PMID 8626773. Su TT, O'Farrell PH (1998). "Chromosome Association of MinichromosomeMaintenance Proteins in Drosophila Endoreplication Cycles". Journal of Cell...
"Chromatin Association of Human Origin Recognition Complex, Cdc6, and MinichromosomeMaintenance Proteins during the Cell Cycle: Assembly of Prereplication Complexes...
MCM10 minichromosomemaintenance deficient 10 (S. cerevisiae)". Thu YM, Bielinsky AK (June 2014). "MCM10: one tool for all—Integrity, maintenance and damage...
methanogenic archaea of the order Methanococcales, the cellular minichromosomemaintenance (MCM) helicase has apparently undergone accelerated evolution...
is a protein that in humans is encoded by the MCM3AP gene. The minichromosomemaintenance protein 3 (MCM3) is one of the MCM proteins essential for the...
"Chromatin association of human origin recognition complex, cdc6, and minichromosomemaintenance proteins during the cell cycle: assembly of prereplication complexes...
Ishimi Y, Ichinose S, Omori A, et al. (1996). "Binding of human minichromosomemaintenance proteins with histone H3". J. Biol. Chem. 271 (39): 24115–22....
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