ORC4 information

ORC4
Identifiers
Aliases	ORC4, ORC4L, ORC4P, origin recognition complex subunit 4
External IDs	OMIM: 603056; MGI: 1347043; HomoloGene: 8059; GeneCards: ORC4; OMA:ORC4 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	148,021,604 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	48,840,289 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; oocyte; ; islet of Langerhans; ; ganglionic eminence; ; kidney tubule; ; bronchial epithelial cell; ; corpus callosum; ; endothelial cell; ; ventricular zone; ; right uterine tube;
	Top expressed in
	otic placode; ; saccule; ; otic vesicle; ; spermatocyte; ; tail of embryo; ; ventricular zone; ; neural layer of retina; ; embryo; ; epiblast; ; superior frontal gyrus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; DNA binding; DNA replication origin binding; protein binding; ATP binding;
Cellular component	nuclear origin of replication recognition complex; nucleolus; origin recognition complex; nucleus; nucleoplasm; cytosol;
Biological process	G1 phase; DNA replication; DNA replication initiation; G1/S transition of mitotic cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	5000
	26428
	ENSG00000115947
	ENSMUSG00000026761
	O43929
	O88708
NM_001190879; NM_001190881; NM_001190882; NM_002552; NM_181741;
	NM_181742; NM_001374270; NM_001374272
	NM_001177313; NM_011958; NM_001355296
NP_001177808; NP_001177810; NP_001177811; NP_002543; NP_859525;
	NP_859526; NP_001361199; NP_001361201
	NP_001170784; NP_036088; NP_001342225
	Wikidata
View/Edit Human	View/Edit Mouse

Origin recognition complex subunit 4 is a protein that in humans is encoded by the ORC4 (ORC4L) gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000115947 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026761 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Quintana DG, Hou ZH, Thome KC, Hendricks M, Saha P, Dutta A (Nov 1997). "Identification of HsORC4, a member of the human origin of replication recognition complex". The Journal of Biological Chemistry. 272 (45): 28247–51. doi:10.1074/jbc.272.45.28247. PMID 9353276.
^ Eki T, Dean FB, Kohda A, Okumura K, Abe M, Murakami Y, Ishiai M, Satomoto K, Hurwitz J, O'Donnell M, Hanaoka F (October 1998). "Assignment of the homologue of the yeast origin recognition complex subunit ORC4 (ORC4L) to human chromosome band 2q22→q23 by in situ hybridization and somatic cell hybrid analysis". Cytogenetics and Cell Genetics. 81 (1): 89–90. doi:10.1159/000014997. PMID 9691185. S2CID 46878915.
^ "Entrez Gene: ORC4L origin recognition complex, subunit 4-like (yeast)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000115947 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026761 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9353276-5] Quintana DG, Hou ZH, Thome KC, Hendricks M, Saha P, Dutta A (Nov 1997). "Identification of HsORC4, a member of the human origin of replication recognition complex". The Journal of Biological Chemistry. 272 (45): 28247–51. doi:10.1074/jbc.272.45.28247. PMID 9353276.

[pmid9691185-6] Eki T, Dean FB, Kohda A, Okumura K, Abe M, Murakami Y, Ishiai M, Satomoto K, Hurwitz J, O'Donnell M, Hanaoka F (October 1998). "Assignment of the homologue of the yeast origin recognition complex subunit ORC4 (ORC4L) to human chromosome band 2q22→q23 by in situ hybridization and somatic cell hybrid analysis". Cytogenetics and Cell Genetics. 81 (1): 89–90. doi:10.1159/000014997. PMID 9691185. S2CID 46878915.

[entrez-7] "Entrez Gene: ORC4L origin recognition complex, subunit 4-like (yeast)".

ORC4 information

and 19 Related for: ORC4 information

ORC4

DNA replication

Origin of replication

Primordial dwarfism

Origin recognition complex

DNA polymerase epsilon

AAA proteins

Eukaryotic DNA replication

POLD3

Margreta Elkins

Opera Rara

Anindya Dutta

ORC2

ORC1

POLE2

ORC6

ORC3

ORC5

POLE4