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Cromoglicic acid information


Cromoglicic acid
Clinical data
AHFS/Drugs.comInternational Drug Names
License data
  • US FDA: Cromolyn
Pregnancy
category
  • AU: B1
Routes of
administration
topical: oral, nasal spray, inhaled, eye drops
ATC code
  • A07EB01 (WHO) D11AH03 (WHO) R01AC01 (WHO) R03BC01 (WHO) S01GX01 (WHO)
Legal status
Legal status
  • AU: S2 (Pharmacy medicine)
  • UK: inhaler POM; eye OTC
  • US: OTC nasal; eye, inhaler: Rx only
Pharmacokinetic data
Bioavailability1%
Elimination half-life1.3 hours
Identifiers
IUPAC name
  • 5,5′-(2-hydroxypropane-1,3-diyl)bis(oxy)bis(4-oxo-4H-chromene-2-carboxylic acid)
CAS Number
  • 16110-51-3 checkY
PubChem CID
  • 2882
IUPHAR/BPS
  • 7608
DrugBank
  • DB01003 ☒N
ChemSpider
  • 2779 checkY
UNII
  • Y0TK0FS77W
KEGG
  • D07753 checkY
ChEBI
  • CHEBI:59773 checkY
ChEMBL
  • ChEMBL74 ☒N
CompTox Dashboard (EPA)
  • DTXSID4022860 Edit this at Wikidata
ECHA InfoCard100.036.602 Edit this at Wikidata
Chemical and physical data
FormulaC23H16O11
Molar mass468.370 g·mol−1
3D model (JSmol)
  • Interactive image
SMILES
  • O=C(O)C=4Oc3cccc(OCC(O)COc2cccc1O/C(=C\C(=O)c12)C(=O)O)c3C(=O)C=4
InChI
  • InChI=1S/C23H16O11/c24-11(9-31-14-3-1-5-16-20(14)12(25)7-18(33-16)22(27)28)10-32-15-4-2-6-17-21(15)13(26)8-19(34-17)23(29)30/h1-8,11,24H,9-10H2,(H,27,28)(H,29,30) checkY
  • Key:IMZMKUWMOSJXDT-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Cromoglicic acid (INN)—also referred to as cromolyn (USAN), cromoglycate (former BAN), or cromoglicate—is traditionally described as a mast cell stabilizer, and is commonly marketed as the sodium salt sodium cromoglicate or cromolyn sodium. This drug prevents the release of inflammatory chemicals such as histamine from mast cells.

It is considered a breakthrough drug in management of asthma, as the patients can be freed from steroids in many cases; however, it is mainly effective as a prophylaxis for allergic and exercise-induced asthma, not as a treatment for acute asthma attacks.[citation needed]

Cromoglicic acid has been the non-corticosteroid treatment of choice in the treatment of asthma, for which it has largely been replaced by leukotriene receptor antagonists because of their safety and convenience. Cromoglicic acid requires administration four times daily, and does not provide additive benefit in combination with inhaled corticosteroids.[1]

  1. ^ Fanta CH (March 2009). "Asthma". The New England Journal of Medicine. 360 (10): 1002–1014. doi:10.1056/NEJMra0804579. PMID 19264689. Review.

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