Calcium gluconate is the calcium salt of gluconic acid and is used as a mineral supplement and medication.[1] As a medication it is used by injection into a vein to treat low blood calcium, high blood potassium, and magnesium toxicity.[1][2] Supplementation is generally only required when there is not enough calcium in the diet.[3] Supplementation may be done to treat or prevent osteoporosis or rickets.[1] It can also be taken by mouth but is not recommended for injection into a muscle.[1]
Side effects when injected include slow heart rate, pain at the site of injection, and low blood pressure.[3] When taken by mouth side effects may include constipation and nausea.[1] Blood calcium levels should be measured when used and extra care should be taken in those with a history of kidney stones.[3] At normal doses, use is regarded as safe in pregnancy and breastfeeding.[1][4] Calcium gluconate is made by mixing gluconic acid with calcium carbonate or calcium hydroxide.[5]
Calcium gluconate came into medical use in the 1920s.[6] It is on the World Health Organization's List of Essential Medicines.[7] Calcium gluconate is available as a generic medication.[2][8]
^ abcdef"Calcium Salts". The American Society of Health-System Pharmacists. Archived from the original on 18 January 2017. Retrieved 8 January 2017.
^ abBritish national formulary : BNF 69 (69 ed.). British Medical Association. 2015. pp. 680, 694. ISBN 9780857111562.
^ abcWorld Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. p. 497. hdl:10665/44053. ISBN 9789241547659.
^"Calcium gluconate Use During Pregnancy | Drugs.com". www.drugs.com. Archived from the original on 18 January 2017. Retrieved 15 January 2017.
^Bhattacharya S (2014). Conventional and Advanced Food Processing Technologies. John Wiley & Sons. p. 391. ISBN 9781118406304. Archived from the original on 18 September 2017.
^Tegethoff FW (2012). Calcium Carbonate: From the Cretaceous Period into the 21st Century. Birkhäuser. p. 308. ISBN 9783034882453. Archived from the original on 18 September 2017.
^World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
^"Competitive Generic Therapy Approvals". U.S. Food and Drug Administration (FDA). 29 June 2023. Archived from the original on 29 June 2023. Retrieved 29 June 2023.
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aging Cheddar cheese. The solubility of calcium L-lactate in water increases significantly in presence of d-gluconate ions, from 6.7 g/dl) at 25 °C to 9.74...
Initial treatment in those with ECG changes is salts, such as calciumgluconate or calcium chloride. Other medications used to rapidly reduce blood potassium...
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condition includes: Intravenous calciumgluconate 10% can be administered, or if the hypocalcaemia is severe, calcium chloride is given instead. This...
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possible with intravenous calcium (e.g. as calciumgluconate). Calciumgluconate can be given via a peripheral IV, however other calcium formulations require...
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space into the intracellular spaces within skeletal muscle cells, and calciumgluconate is used to stabilise the myocardium in hyperkalaemic patients, in...
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