Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references
Chemical compound
Deoxycholic acid
Clinical data
Trade names
Kybella, Belkyra
AHFS/Drugs.com
Monograph
License data
US DailyMed: Deoxycholic_acid
Identifiers
PDB ligand
DXC (PDBe, RCSB PDB)
CompTox Dashboard (EPA)
DTXSID0042662
ECHA InfoCard
100.001.344
Deoxycholic acid is a bile acid. Deoxycholic acid is one of the secondary bile acids, which are metabolic byproducts of intestinal bacteria. The two primary bile acids secreted by the liver are cholic acid and chenodeoxycholic acid. Bacteria metabolize chenodeoxycholic acid into the secondary bile acid lithocholic acid, and they metabolize cholic acid into deoxycholic acid. There are additional secondary bile acids, such as ursodeoxycholic acid. Deoxycholic acid is soluble in alcohol and acetic acid. When pure, it exists in a white to off-white crystalline powder form.
Deoxycholic acid is available as a generic medication in the United States as of April 2021, sold under the brand name Kybella among others.[8]
^"Deoxycholic acid" (PDF). Sigma Aldrich. Archived from the original (PDF) on 2020-06-06. Retrieved 2013-10-10.
^Lide DR (1998). Handbook of Chemistry and Physics (87 ed.). Boca Raton, FL: CRC Press. p. 1287. ISBN 978-0-8493-0594-8.
^ ab"Belkyra (deoxycholic acid solution for injection) Product Information" (PDF). TGA. Archived from the original on 25 June 2021. Retrieved 23 June 2021.
^https://www.ebs.tga.gov.au/servlet/xmlmillr6?dbid=ebs/PublicHTML/pdfStore.nsf&docid=6CC2E7A2D27AA7C5CA2585D80042A1CC&agid=(PrintDetailsPublic)&actionid=1[permanent dead link]
^"Prescription medicines: registration of new chemical entities in Australia, 2016". Therapeutic Goods Administration (TGA). 21 June 2022. Archived from the original on 10 April 2023. Retrieved 10 April 2023.
^"Kybella- deoxycholic acid injection, solution". DailyMed. Archived from the original on 24 June 2021. Retrieved 20 June 2021.
^"Active substance: deoxycholic acid" (PDF). European Medicines Agency (EMA). 10 December 2020. Archived (PDF) from the original on 28 August 2021. Retrieved 23 January 2021.
^"Deoxycholic acid: FDA-Approved Drugs". U.S. Food and Drug Administration (FDA). Archived from the original on 24 June 2021. Retrieved 19 June 2021.
Deoxycholicacid is a bile acid. Deoxycholicacid is one of the secondary bile acids, which are metabolic byproducts of intestinal bacteria. The two primary...
cells. While some bile acids are known to be colon tumor promoters (e.g. deoxycholicacid), others such as ursodeoxycholic acid are thought to be chemopreventive...
results with the pressurized injection system. In the United States, deoxycholicacid, under the brand name Kybella, is approved by the Food and Drug Administration...
of deoxycholicacid, a product of bile acid alteration by certain gut microbes, and these microbes are increased with obesity. The excess deoxycholic acid...
Hyaluronic acid (/ˌhaɪ.əljʊəˈrɒnɪk/; abbreviated HA; conjugate base hyaluronate), also called hyaluronan, is an anionic, nonsulfated glycosaminoglycan...
taurocholic acid in newborn rats is 380 mg/kg.[citation needed] Deoxycholicacid Anwer, M. Sawkat (2004). "Cellular regulation of hepatic bile acid transport...
differs from deoxycholicacid in that the 6α-hydroxyl is in the 12 position in the former. The 6α-hydroxyl group makes HDCA a hydrophilic acid, a property...
Cromoglicic acid (INN)—also referred to as cromolyn (USAN), cromoglycate (former BAN), or cromoglicate—is traditionally described as a mast cell stabilizer...
reactive compounds. It is typically stored with a stabilizer in a weakly acidic solution in an opaque bottle. Hydrogen peroxide is found in biological systems...
Calcium gluconate is the calcium salt of gluconic acid and is used as a mineral supplement and medication. As a medication it is used by injection into...
hormone and vitamin D. Some publications point towards the effect of deoxycholicacid (DCA) as an immunostimulant of the non-specific immune system, activating...
detergents are produced annually for the domestic markets. Bile acids, such as deoxycholicacid (DOC), are anionic detergents produced by the liver to aid...
which is structurally similar to cumene hydroperoxide and rearranges in acid to give acetone and hydroquinone. A second route involves hydroxylation of...
process that started with deoxycholicacid, which was extracted from ox bile. The low efficiency of converting deoxycholicacid into cortisone led to a...
diet is linked to elevated levels of bile acids in the colon, particularly deoxycholicacid. Deoxycholicacid induces autophagy in non-cancer colon epithelial...
jejuni. When C. jejuni is grown in a medium containing the bile aciddeoxycholicacid, a component of bile, the DNA of C. jejuni is damaged by a process...
group to produce cholic acid. Some other mammals have muricholic acid or deoxycholicacid rather than chenodeoxycholic acid. It occurs as a white crystalline...
decreased abundance of secondary bile acids such as lithocholic acid and deoxycholicacid. The human microbiota consists of 10–100 trillion microorganisms. Several...
swelling and hydrolysis of skin), salicylic acid, urea, lactic acid, allantoin, glycolic acid, and trichloroacetic acid. While cytostatic agents such as zinc...
5-Dimethoxy-4-chloroamphetamine, a psychedelic amphetamine DOC, Deoxycholicacid, a bile acid Day-old cockerel, a term in falconry Diesel Oxidation Catalyst...
such as salmonella, XLD agar which contains, among other ingredients deoxycholicacid is used. Bacteria were first observed by the Dutch microscopist Antonie...
States, with more than 11 million prescriptions. It is available as its acid or in two salts, as either diclofenac sodium or potassium. It is also widely...
Müller-Calgan H, "2-(2,6-dimethyl-3-hydroxy-4-tert-butyl-benzyl)-2-imidazoline,and acid addition salts thereof,and process for their manufacture", issued 23 November...
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