Micrograph of mastocytosis. Skin biopsy. H&E stain.
Specialty
Clinical Immunology and Allergy, Oncology, hematology
Mastocytosis, a type of mast cell disease, is a rare disorder affecting both children and adults caused by the accumulation of functionally defective mast cells (also called mastocytes) and CD34+ mast cell precursors.[1]
People affected by mastocytosis are susceptible to a variety of symptoms, including itching, hives, and anaphylactic shock, caused by the release of histamine and other pro-inflammatory substances from mast cells.[2]
^Horny HP, Sotlar K, Valent P (2007). "Mastocytosis: state of the art". Pathobiology. 74 (2): 121–32. doi:10.1159/000101711. PMID 17587883.
^"Mastocytosis & mast cell disorders". Mastocytosis Society Canada. Archived from the original on 2013-12-28. Retrieved 2017-11-02.
found in >90% of patients with systemic mastocytosis. Diagnosis of urticaria pigmentosa (cutaneous mastocytosis, see above) can often be done by seeing...
generalized eruption of cutaneous mastocytosis (childhood type): 616 ) is the most common form of cutaneous mastocytosis. It is a rare disease caused by...
"Cutaneous manifestations in patients with mastocytosis: Consensus report of the European Competence Network on Mastocytosis; the American Academy of Allergy,...
of patients with adult onset systemic mastocytosis and approximately 40% of children with cutaneous mastocytosis are positive for the D816V c-Kit activating...
treatment of adults with advanced systemic mastocytosis, aggressive systemic mastocytosis, systemic mastocytosis with an associated hematological neoplasm...
this activity is dependent on antibodies and complement components. Mastocytosis is a rare clonal mast cell disorder involving the presence of too many...
"Prognosis in adult indolent systemic mastocytosis: a long-term study of the Spanish Network on Mastocytosis in a series of 145 patients". The Journal...
allergic conjunctivitis in an oral form (Gastrocrom, Nalcrom) to treat mastocytosis, mast cell activation syndrome, dermatographic urticaria and ulcerative...
c-KIT mutations and occurs in 80% of patients with mastocytosis. However, there are also mastocytosis patients without alterations in the stem cell factor...
lymphoma Leishmaniasis Lipoid proteinosis Progressive nodular histiocytosis Mastocytosis Hyperimmunoglobulin E syndrome, also known as Job's syndrome Facies Leontiasis...
ketotifen has shown efficacy in managing systemic mast cell diseases such as mastocytosis and mast cell activation syndrome (MCAS), which involve abnormal accumulation...
It may also be used as an adjunct therapy in symptomatic treatment of mastocytosis. It is taken by mouth, as a tablet, chewable tablet, or as granules....
mast cell diseases, including mastocytosis, mast cell activation syndrome and hereditary alpha tryptasimia. Mastocytosis is a rare disease with limited...
Finally, in oral form, they are used to treat the rare condition of mastocytosis. Mast cell stabilizer medications include: Cromoglicic acid (Cromolyn/cromoglycate)...
histamine may be involved in immune system disorders and allergies. Mastocytosis is a rare disease in which there is a proliferation of mast cells that...
Urticaria pigmentosa Mastocytosis with a clinical picture of darkish spots. Not otherwise specified Includes the rare disease of primary mastocytosis....
heparin, platelet-activating factor, and other substances. Disseminated mastocytosis is rarely seen in young dogs and cats, while mast cell tumors are usually...
mononucleosis Primary sclerosing cholangitis Polycythemia vera Myelofibrosis Mastocytosis Leukemoid reaction to infection Women using hormonal contraception Pregnancy...
(medication induced, thyrotoxicosis, caffeine, cocaine, anemia, amphetamine, mastocytosis). The cardiac etiologies of palpitations are the most life-threatening...
formation of FIP1L1-PDGFRA fusion genes or the presence of systemic mastocytosis. Tryptase is involved with allergenic response and is suspected to act...
hypereosinophilic syndrome (HES), chronic eosinophilic leukemia (CEL), systemic mastocytosis, and myelodysplastic syndrome. Common side effects include vomiting,...
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