Crisaborole information

Crisaborole
Clinical data
Pronunciation	/juːˈkrɪsə/ yoo-KRIS-ə
Trade names	Eucrisa, Staquis
Other names	AN-2728
AHFS/Drugs.com	Monograph
MedlinePlus	a617019
License data	EU EMA: by INN; US DailyMed: Crisaborole;
Pregnancy; category	AU: B1; ;
Routes of; administration	Topical (ointment)
ATC code	D11AH06 (WHO) ;
Legal status
Legal status	CA: ℞-only; US: ℞-only; EU: authorization withdrawn on request of pharmaceutical company; In general: ℞ (Prescription only);
Identifiers
	IUPAC name 4-[(1-Hydroxy-1,3-dihydro-2,1-benzoxaborol-5-yl)oxy]benzonitrile;
CAS Number	906673-24-3;
PubChem CID	44591583;
DrugBank	DB05219;
ChemSpider	24701949;
UNII	Q2R47HGR7P;
KEGG	D10873;
ChEBI	CHEBI:134677 ;
ChEMBL	ChEMBL484785;
CompTox Dashboard (EPA)	DTXSID10238231 ;
ECHA InfoCard	100.225.309
Chemical and physical data
Formula	C14H10BNO3
Molar mass	251.05 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES B1(c2ccc(cc2CO1)Oc3ccc(cc3)C#N)O;
	InChI InChI=1S/C14H10BNO3/c16-8-10-1-3-12(4-2-10)19-13-5-6-14-11(7-13)9-18-15(14)17/h1-7,17H,9H2; Key:USZAGAREISWJDP-UHFFFAOYSA-N;

Crisaborole, sold under the brand name Eucrisa among others, is a nonsteroidal topical medication used for the treatment of mild-to-moderate atopic dermatitis (eczema) in adults and children.^[1]^[2]^[3]^[4]

The most common side effects are reactions at the application site (including burning or stinging).^[3]

Crisaborole is a phosphodiesterase 4 (PDE-4) inhibitor, although its specific mechanism of action in atopic dermatitis is not known.^[1]^[2]

^ ^a ^b "FDA Approves Eucrisa for Eczema" (Press release). U.S. Food and Drug Administration (FDA). 14 December 2016. This article incorporates text from this source, which is in the public domain.
^ ^a ^b "Eucrisa- crisaborole ointment". DailyMed. 21 April 2020. Retrieved 28 April 2020.
^ ^a ^b Cite error: The named reference Staquis EPAR was invoked but never defined (see the help page).
^ He Y, Liu J, Wang Y, Kuai W, Liu R, Wu J (6 February 2023). Pimpinelli N (ed.). "Topical Administration of Crisaborole in Mild to Moderate Atopic Dermatitis: A Systematic Review and Meta-Analysis". Dermatologic Therapy. 2023: 1–9. doi:10.1155/2023/1869934. ISSN 1529-8019.

[FDA_PR-1] "FDA Approves Eucrisa for Eczema" (Press release). U.S. Food and Drug Administration (FDA). 14 December 2016. This article incorporates text from this source, which is in the public domain.

[Eucrisa_FDA_label-2] "Eucrisa- crisaborole ointment". DailyMed. 21 April 2020. Retrieved 28 April 2020.

[Staquis_EPAR-3] Cite error: The named reference Staquis EPAR was invoked but never defined (see the help page).

[4] He Y, Liu J, Wang Y, Kuai W, Liu R, Wu J (6 February 2023). Pimpinelli N (ed.). "Topical Administration of Crisaborole in Mild to Moderate Atopic Dermatitis: A Systematic Review and Meta-Analysis". Dermatologic Therapy. 2023: 1–9. doi:10.1155/2023/1869934. ISSN 1529-8019.

Crisaborole information

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Clinical data

Pronunciation	/juːˈkrɪsə/ yoo-KRIS-ə
Trade names	Eucrisa, Staquis
Other names	AN-2728
AHFS/Drugs.com	Monograph
MedlinePlus	a617019
License data	EU EMA: by INN US DailyMed: Crisaborole
Pregnancy category	AU: B1
Routes of administration	Topical (ointment)
ATC code	D11AH06 (WHO)
Legal status
Legal status	CA: ℞-only US: ℞-only EU: authorization withdrawn on request of pharmaceutical company In general: ℞ (Prescription only)
Identifiers
IUPAC name 4-[(1-Hydroxy-1,3-dihydro-2,1-benzoxaborol-5-yl)oxy]benzonitrile
CAS Number	906673-24-3
PubChem CID	44591583
DrugBank	DB05219
ChemSpider	24701949
UNII	Q2R47HGR7P
KEGG	D10873
ChEBI	CHEBI:134677^Y
ChEMBL	ChEMBL484785
CompTox Dashboard (EPA)	DTXSID10238231
ECHA InfoCard	100.225.309
Chemical and physical data
Formula	C₁₄H₁₀BNO₃
Molar mass	251.05 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES B1(c2ccc(cc2CO1)Oc3ccc(cc3)C#N)O
InChI InChI=1S/C14H10BNO3/c16-8-10-1-3-12(4-2-10)19-13-5-6-14-11(7-13)9-18-15(14)17/h1-7,17H,9H2 Key:USZAGAREISWJDP-UHFFFAOYSA-N