Crofelemer information

Crofelemer
Clinical data
Trade names	Mytesi
Other names	SP-303
AHFS/Drugs.com	Monograph
MedlinePlus	a613016
License data	US DailyMed: Crofelemer; US FDA: Crofelemer;
Routes of; administration	By mouth (oral tablets)
ATC code	A07XA06 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only); US: ℞-only;
Pharmacokinetic data
Bioavailability	Little or no absorption from the gut
Identifiers
CAS Number	148465-45-6;
PubChem SID	17397714;
DrugBank	DB04941;
ChemSpider	none;
UNII	PY79D6C8RX;
KEGG	D03605;
CompTox Dashboard (EPA)	DTXSID50858715 ;
Chemical and physical data
Formula	(C15O6,7H12)n
Molar mass	860–9100 g·mol−1

Crofelemer (USAN, trade name Mytesi) is an antidiarrheal indicated for the symptomatic relief of non-infectious diarrhea in adult patients with HIV/AIDS on antiretroviral therapy.^[1] Other possible uses include diarrhea in children, acute infectious diarrhea, and diarrhea in patients with irritable bowel syndrome.^[2] It is a purified oligomeric proanthocyanidin from "dragon's blood", the sap of the South American tree Croton lechleri.^[3]

Crofelemer treats the symptoms of disease, but it is not used to treat infectious diarrhea (diarrhea caused by infection of the digestive system by a bacterium, virus or parasite). It was initially developed by Napo Pharmaceuticals, which is a wholly owned subsidiary of Jaguar Health, Inc. A Phase III clinical trial for diarrhea in HIV patients was completed in 2012, and the drug was approved by the US Food and Drug Administration (FDA) on 31 December 2012.^[4]^[5]^[6]

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