Lamotrigine, sold under the brand name Lamictal among others, is a medication used to treat epilepsy and stabilize mood in bipolar disorder.[5][8] For epilepsy, this includes focal seizures, tonic-clonic seizures, and seizures in Lennox-Gastaut syndrome.[8] In bipolar disorder, lamotrigine has not been shown to reliably treat acute depression for all groups except in the severely depressed; but for patients with bipolar disorder who are not currently symptomatic, it appears to reduce the risk of future episodes of depression.[9]
Common side effects include nausea, sleepiness, headache, vomiting, trouble with coordination, and rash.[8] Serious side effects include excessive breakdown of red blood cells, increased risk of suicide, severe skin reaction (Stevens–Johnson syndrome), and allergic reactions, which can be fatal.[8] Lamotrigine is a phenyltriazine,[5] making it chemically different from other anticonvulsants.[8] Its mechanism of action is not clear, but it appears to inhibit release of excitatory neurotransmitters via voltage-sensitive sodium channels and voltage-gated calcium channels in neurons.[8][10][11]
Lamotrigine was first marketed in Ireland in 1991,[12] and approved for use in the United States in 1994.[8][13] It is on the World Health Organization's List of Essential Medicines.[14] In 2021, it was the 50th most commonly prescribed medication in the United States, with more than 13million prescriptions.[15][16]
^Cite error: The named reference brands was invoked but never defined (see the help page).
^"Lamotrigine Use During Pregnancy". Drugs.com. 8 October 2019. Archived from the original on 25 January 2021. Retrieved 24 March 2020.
^"FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 October 2023.
^Anvisa (31 March 2023). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 4 April 2023). Archived from the original on 3 August 2023. Retrieved 16 August 2023.
^ abcCite error: The named reference Lamictal FDA label was invoked but never defined (see the help page).
^"Lamictal XR- lamotrigine tablet, film coated, extended release Lamictal XR- lamotrigine kit". DailyMed. 13 April 2022. Archived from the original on 27 August 2022. Retrieved 27 August 2022.
^"Lamictal". European Medicines Agency. 17 September 2018. Archived from the original on 27 August 2022. Retrieved 27 August 2022.
^ abcdefg"Lamotrigine". The American Society of Health-System Pharmacists. Archived from the original on 10 December 2017. Retrieved 8 December 2017.
^"Lamotrigine: Its Role in Bipolar Disorder". PsychiatricTimes. 26 November 2019. Archived from the original on 26 January 2021. Retrieved 1 September 2020.
^"Lamotrigine". PubChem Open Chemistry Database. US: National Institutes of Health. Archived from the original on 6 September 2016. Retrieved 13 December 2016.
^Goldsmith DR, Wagstaff AJ, Ibbotson T, Perry CM (1 October 2003). "Lamotrigine: a review of its use in bipolar disorder". Drugs. 63 (19): 2029–2050. doi:10.2165/00003495-200363190-00009. PMID 12962521. Archived from the original on 27 August 2022. Retrieved 15 January 2022.
^Cite error: The named reference pmid 18001843 was invoked but never defined (see the help page).
^Shorvon SD, Perucca E, Engel J (2015). The Treatment of Epilepsy (4th ed.). John Wiley & Sons, Incorporated. p. 1321. ISBN 9781118936993. Archived from the original on 2 August 2021. Retrieved 31 August 2020.
^World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
^"The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.
^"Lamotrigine - Drug Usage Statistics". ClinCalc. Retrieved 14 January 2024.
Lamotrigine, sold under the brand name Lamictal among others, is a medication used to treat epilepsy and stabilize mood in bipolar disorder. For epilepsy...
there is evidence for using gabapentin, lamotrigine, oxcarbazepine or topiramate as monotherapy. Lamotrigine can be included in the options for children...
are of equal efficacy controlling absences in around 75% of patients. Lamotrigine monotherapy is less effective, controlling absences in around 50% of...
group. These molecules are pharmacologically important. As an example, lamotrigine is a phenyltriazine derivative used as an anticonvulsant drug and has...
the strong enzyme-inducing ASMs. Clobazam, eslicarbazepine, felbamate, lamotrigine, rufinamide and topiramate are examples of weak enzyme-inducing ASMs...
when taken as a free acid. Liver function and CBC should be monitored. Lamotrigine (aka Lamictal) – FDA approved for bipolar disorder maintenance therapy...
therapy with lamotrigine, these complex visual disturbances receded almost completely. There are also many anecdotal reports on lamotrigine alleviating...
studies, lamotrigine as a treatment for visual snow syndrome only showed efficiacy in 20% of patients, and in one study, patients using lamotrigine even reported...
bipolar disorder) and migraine.[citation needed] The anticonvulsant drug, lamotrigine, has been associated with a decrease in white blood cell count. The FDA...
evidence that lamotrigine decreases the risk of relapse in rapid-cycling BP-II. It is more effective in BP-II than BP-I, suggesting that lamotrigine is more...
or valproate. Lamotrigine has some efficacy in treating depression, and this benefit is greatest in more severe depression. Lamotrigine may have a similar...
drug withdrawal in as many as 23% of patients. Other options include lamotrigine, baclofen, gabapentin, amitriptyline and pimozide. Opioids are not usually...
avenue of treatment, with medications such as clomipramine, fluoxetine, lamotrigine, and opioid antagonists being commonly prescribed. However, it is important...
has been reported with imatinib, resulting in hepatotoxicity, and with lamotrigine. The common ginsengs (P. ginseng and P. quinquefolia) are generally considered...
organ failure. The most common cause is certain medications such as lamotrigine, carbamazepine, allopurinol, sulfonamide antibiotics, and nevirapine...
anti-epileptic drug lamotrigine for 6 weeks, it was revealed that the contraceptive effectiveness could be lowered, despite lamotrigine not being an enzyme...
Psychotomimetic effects limit the acceptance of ketamine; however, lamotrigine and nimodipine decrease psychotomimetic effects and can be counteracted...
of the very few anticonvulsants [see: levetiracetam, carbamazepine, lamotrigine] that do not induce apoptosis in young animals at doses needed to produce...
and Drug Administration (FDA) announced a voluntary recall of 100 mg Lamotrigine (Generic for Lamictal) tablets manufactured by Taro Pharmaceuticals USA...
may have fewer side effects. In the United Kingdom, carbamazepine or lamotrigine are recommended as first-line treatment for focal seizures, with levetiracetam...
Global Information
(what is this?) (verify)
