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Consensus sequence information


In molecular biology and bioinformatics, the consensus sequence (or canonical sequence) is the calculated sequence of most frequent residues, either nucleotide or amino acid, found at each position in a sequence alignment. It represents the results of multiple sequence alignments in which related sequences are compared to each other and similar sequence motifs are calculated. Such information is important when considering sequence-dependent enzymes such as RNA polymerase.[1]

  1. ^ Pierce, Benjamin A. 2002. Genetics : A Conceptual Approach. 1st ed. New York: W.H. Freeman and Co.

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Consensus sequence

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molecular biology and bioinformatics, the consensus sequence (or canonical sequence) is the calculated sequence of most frequent residues, either nucleotide...

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Kozak consensus sequence

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The Kozak consensus sequence (Kozak consensus or Kozak sequence) is a nucleic acid motif that functions as the protein translation initiation site in...

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Sequence logo

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sequences). A sequence logo is created from a collection of aligned sequences and depicts the consensus sequence and diversity of the sequences. Sequence logos...

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Consensus

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database. Consensus sequence, the order of nucleotide or amino acid residues most frequently found within a DNA, RNA or protein sequence. Consensus theorem...

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DNA unwinding element

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initiation. In prokaryotes, DUEs are found in the form of tandem consensus sequences flanking the 5' end of DnaA binding domain. The act of unwinding...

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TATA box

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called the Pribnow box which has a shorter consensus sequence. The TATA box is considered a non-coding DNA sequence (also known as a cis-regulatory element)...

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Sequence motif

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Such techniques belong to the discipline of bioinformatics. See also consensus sequence. Consider the N-glycosylation site motif mentioned above: Asn, followed...

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Sequence alignment

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For multiple sequences the last row in each column is often the consensus sequence determined by the alignment; the consensus sequence is also often...

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Pribnow box

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DNA for transcription to occur in bacteria. It is an idealized or consensus sequence—that is, it shows the most frequently occurring base at each position...

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Nucleic acid sequence

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Shine-Dalgarno sequence, the Kozak consensus sequence and the RNA polymerase III terminator. In bioinformatics, a sequence entropy, also known as sequence complexity...

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Phred quality score

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scores is the automatic determination of accurate, quality-based consensus sequences. Phred quality scores Q {\displaystyle Q} are logarithmically related...

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CAAT box

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box or CAT box) is a distinct pattern of nucleotides with GGCCAATCT consensus sequence that occur upstream by 60–100 bases to the initial transcription site...

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Split gene theory

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box (consensus sequence TATAAA), which contains the stop codon TAA. Bacterial promoter elements at ~10 bases exhibits a TATA box with a consensus of TATAAT...

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IRF8

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Interferon regulatory factor 8 (IRF8) also known as interferon consensus sequence-binding protein (ICSBP), is a protein that in humans is encoded by the...

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Upstream activating sequence

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conditions. The inositol-sensitive upstream activation sequence (UASINO) has a consensus sequence 5'-CATGTGAAAT-3' and is present in the promoter regions...

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Phrap

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is sequenced several times in the same direction. If a consensus base is covered by both high-quality sequence and (discrepant) low-quality sequence, Phrap's...

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Gene

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initiate transcription.: 7.1  The recognition typically occurs as a consensus sequence like the TATA box. A gene can have more than one promoter, resulting...

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Nuclear localization sequence

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mediator. Chelsky et al. proposed the consensus sequence K-K/R-X-K/R for monopartite NLSs. A Chelsky sequence may, therefore, be part of the downstream...

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Electrophoretic mobility shift assay

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large sets of consensus sequences are multiplexed in each reaction, and where one set competes for binding, the individual consensus sequences from this set...

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Protein targeting

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proteins to specific intracellular or extracellular locations. While no consensus sequence has been identified for signal peptides, many nonetheless possess...

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Alternative splicing

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branchpoint is always an A; the consensus around this sequence varies somewhat. In humans the branch site consensus sequence is yUnAy. The branch site is...

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Glycosaminoglycan

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consensus sequence of E(E/L)PFPS. Additionally, for three other keratan sulfated proteoglycans, lumican, keratocan, and mimecan (OGN), the consensus sequence...

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Transposable element

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repeat identification involves building a consensus of each family of sequences. A consensus sequence is a sequence that is created based on the repeats that...

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Bordetella

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to a consensus sequence present within the coding sequences of at least some Bvg-repressed genes. Binding of this protein to the consensus sequence represents...

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Autonomously replicating sequence

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functioning of the origin. Element A is highly conserved, consisting of the consensus sequence: 5'- T/A T T T A Y R T T T T/A -3' (where Y is either pyrimidine and...

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