In molecular biology, the TATA box (also called the Goldberg–Hogness box)[1] is a sequence of DNA found in the core promoter region of genes in archaea and eukaryotes.[2] The bacterial homolog of the TATA box is called the Pribnow box which has a shorter consensus sequence.
The TATA box is considered a non-coding DNA sequence (also known as a cis-regulatory element). It was termed the "TATA box" as it contains a consensus sequence characterized by repeating T and A base pairs.[3] How the term "box" originated is unclear. In the 1980s, while investigating nucleotide sequences in mouse genome loci, the Hogness box sequence was found and "boxed in" at the -31 position.[4] When consensus nucleotides and alternative ones were compared, homologous regions were "boxed" by the researchers.[4] The boxing in of sequences sheds light on the origin of the term "box".
The TATA box was first identified in 1978[1] as a component of eukaryotic promoters. Transcription is initiated at the TATA box in TATA-containing genes. The TATA box is the binding site of the TATA-binding protein (TBP) and other transcription factors in some eukaryotic genes. Gene transcription by RNA polymerase II depends on the regulation of the core promoter by long-range regulatory elements such as enhancers and silencers.[5] Without proper regulation of transcription, eukaryotic organisms would not be able to properly respond to their environment.
Based on the sequence and mechanism of TATA box initiation, mutations such as insertions, deletions, and point mutations to this consensus sequence can result in phenotypic changes. These phenotypic changes can then turn into a disease phenotype. Some diseases associated with mutations in the TATA box include gastric cancer, spinocerebellar ataxia, Huntington's disease, blindness, β-thalassemia, immunosuppression, Gilbert's syndrome, and HIV-1. The TATA-binding protein (TBP) could also be targeted by viruses as a means of viral transcription.[6]
^ abLifton RP, Goldberg ML, Karp RW, Hogness DS (1978). "The organization of the histone genes in Drosophila melanogaster: functional and evolutionary implications". Cold Spring Harbor Symposia on Quantitative Biology. 42 (2): 1047–51. doi:10.1101/sqb.1978.042.01.105. PMID 98262.
^Smale ST, Kadonaga JT (2003). "The RNA polymerase II core promoter". Annual Review of Biochemistry. 72: 449–79. doi:10.1146/annurev.biochem.72.121801.161520. PMID 12651739.
^Cite error: The named reference :4 was invoked but never defined (see the help page).
^ abOhshima Y, Okada N, Tani T, Itoh Y, Itoh M (October 1981). "Nucleotide sequences of mouse genomic loci including a gene or pseudogene for U6 (4.8S) nuclear RNA". Nucleic Acids Research. 9 (19): 5145–58. doi:10.1093/nar/9.19.5145. PMC 327505. PMID 6171774.
^Cite error: The named reference :16 was invoked but never defined (see the help page).
^Mainz D, Quadt I, Stranzenbach AK, Voss D, Guarino LA, Knebel-Mörsdorf D (June 2014). "Expression and nuclear localization of the TATA-box-binding protein during baculovirus infection". The Journal of General Virology. 95 (Pt 6): 1396–407. doi:10.1099/vir.0.059949-0. PMID 24676420. S2CID 33480957.
In molecular biology, the TATAbox (also called the Goldberg–Hogness box) is a sequence of DNA found in the core promoter region of genes in archaea and...
India. Tata Play entered into an agreement with French firm Vantiva to supply 4K set top boxes from early 2015. The company was formerly known as Tata Sky...
the site of initiation of transcription. The Pribnow box has a function similar to the TATAbox that occurs in promoters in eukaryotes and archaea: it...
up tata in Wiktionary, the free dictionary. Tata or TATA may refer to: Jamshedpur, a city in Jharkhand, India also known as Tatanagar or TataTata, Hungary...
core promoter that is similar in function to the Pribnow box (in prokaryotes) or the TATAbox (in eukaryotes). The Inr is the simplest functional promoter...
Naval Tata (born 28 December 1937) is an Indian industrialist, philanthropist and former chairman of Tata Sons. He was a chairman of the Tata Group from...
immediately near TATAbox, and consists of 7 nucleotides. There are two sets of BREs: one (BREu) found immediately upstream of the TATAbox, with the consensus...
promoter region of some eukaryotic genes. The GC box is upstream of the TATAbox, and approximately 110 bases upstream from the transcription initiation...
through specific recognition of promoter sequence motifs, including the TATAbox, Initiator, Downstream Promoter, Motif Ten, or Downstream Regulatory elements...
about as widely used as the TATAbox in D. melanogaster. While a DPE was found in many promoters that do not contain a TATAbox, there are also promoters...
upstream sequences are occasionally seen, e.g. U6 snRNA gene has an upstream TATAbox as seen in Pol II Promoters). There are three classes of Pol III initiation...
produce a functional product". Regulatory elements include: Promoter region TATAbox Polyadenylation sequences Enhancers These elements work in combination...
following GTFs: TFIIA – stabilizes the interaction between the TATAbox and TFIID/TATA binding protein (TBP) TFIIB – recognizes the B recognition element...
found in the promoters. For example, the TATAbox is the highly conserved DNA recognition sequence for the TATAbox binding protein, TBP, whose binding initiates...
Tata Telecom, the joint venture between Tata and Lucent Technologies, was known as a Tata-Avaya. Once the Tata Group sold its 25.1% ownership in Tata...
Tata Novus is the Tata Motors' first new offering from its acquisition of Daewoo's truck manufacturing unit. Tata Novus is based on the Daewoo Novus truck...
the UAS recruiting a mediator. A TATA-binding protein subunit of a transcription factor then binds to the TATAbox, recruiting additional transcription...
TATA-box binding protein associated factor 7 like is a protein that in humans is encoded by the TAF7L gene. This gene is similar to a mouse gene that encodes...
promoter. The TATA-binding protein (TBP, a subunit of TFIID), TBPL1, or TBPL2 can bind the promoter or TATAbox. Most genes lack a TATAbox and use an initiator...
The Tata Indica (from "Indian Car") was a B-segment car launched by the Indian manufacturer Tata Motors in 1998. It was the first Indian hatchback with...