The left model is of the complex of NF-YC/NF-YB with the CCAAT element from the pro- 2(I) collagen promoter. The DNA backbone is shown as ribbons (purple) with the bases displayed. The two possible locations of the CCAAT box, according to the modeling, have been colored cyan. For the right model of the NF-Y/CCAAT complex. NF-YC, NF-YB and DNA are colored as in figure on the left, whereas NF-YA is colored blue. The two alternative positions for the linker connecting NF-YA1 and NF-YA2 sub-domains are shown as blue dotted lines. Secondary structure elements of the histone pair that are implicated in NF-YA1 and NF-YA2 recognition (see text) are labeled and colored in red and gray, respectively. For clarity, only the bases for the CCAAT pentanucleotide are shown and labeled.[1]
In molecular biology, a CCAAT box (also sometimes abbreviated a CAAT box or CAT box) is a distinct pattern of nucleotides with GGCCAATCT consensus sequence that occur upstream by 60–100 bases to the initial transcription site. The CAAT box signals the binding site for the RNA transcription factor, and is typically accompanied by a conserved consensus sequence. It is an invariant DNA sequence at about minus 70 base pairs from the origin of transcription in many eukaryotic promoters. Genes that have this element seem to require it for the gene to be transcribed in sufficient quantities. It is frequently absent from genes that encode proteins used in virtually all cells. This box along with the GC box is known for binding general transcription factors. Both of these consensus sequences belong to the regulatory promoter. Full gene expression occurs when transcription activator proteins bind to each module within the regulatory promoter. Protein specific binding is required for the CCAAT box activation. These proteins are known as CCAAT box binding proteins/CCAAT box binding factors.
A CCAAT box is a feature frequently found before eukaryote coding regions, but is not found in prokaryotes.[2]
^Romier, Christophe; Cocchiarella, Fabienne; Mantovani, Roberto; Moras, Dino (24 October 2002). "The NF-YB/NF-YC Structure Gives Insight into DNA Binding and Transcription Regulation by CCAAT Factor NF-Y". The Journal of Biological Chemistry. 278 (2): 1336–1345. doi:10.1074/jbc.M209635200. PMID 12401788.
^Stedman, Thomas Lathrop (6 December 2005). Stedman's Medical Dictionary, Volume 1 (28th ed.). Lippincott Williams & Wilkins. ISBN 9780781733908.
In molecular biology, a CCAAT box (also sometimes abbreviated a CAATbox or CAT box) is a distinct pattern of nucleotides with GGCCAATCT consensus sequence...
both conserved. A CAATbox (also CAT box) is a region of nucleotides with the following consensus sequence: 5’ GGCCAATCT 3’. The CAATbox is located about...
center Campaign Against Arms Trade, a British campaigning organisation The CAATbox in molecular genetics The Children's Air Ambulance Trust, a fundraising...
regulatory region, like other members of the Acad family, lacks a TATA or CAATbox and is GC rich. This region does contain multiple, putative cis-acting...
Trypanosoma brucei which despite some specific insertions show a similar fold. CAATbox Enhancer (genetics) Initiator element Insulator (genetics) Promoter (biology)...
basepairs upstream of transcription) include elements such as the TATA and CAATboxes, GC elements, and an initiator. Exons are the part of the transcript that...
control FPPS expression through two cis regulatory factors (an inverted CAATbox and SRE-3) in the proximal FPPS promoter. In plants, porphyrin and carotenoids...
approximately 8.2, 3.2, 2.3 and 2.3 kb. The TRAIL gene lacks TATA and CAATboxes and the promoter region contains putative response elements for transcription...
Jochen Richard Mass (German pronunciation: [ˈjɔ.χn̩ ˈʁɪ.çaɐ̯t maːs]; born 30 September 1946) is a German former racing driver. Born in Dorfen, Bavaria...
2 of the hTERT gene. The hTERT promoter is GC-rich and lacks TATA and CAATboxes but contains many sites for several transcription factors giving indication...
region flanking the 5’ end of the gene lacks a TATA box, but contains many GC’s and also has two CAATboxes. The gene also may have a binding site for the...
contains several copies of the SP1 binding motive but no typical TATA or CAATboxes are apparent. Alu repeat elements have been identified within the region...
from the original on 24 July 2008. Retrieved 21 August 2008. Marcel ten Caat (2009-01-20). "15 teams confirm their Le Mans 24 entry". Planet Le Mans....
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