Process in bioinformatics that identifies equivalent sites within molecular sequences
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In bioinformatics, a sequence alignment is a way of arranging the sequences of DNA, RNA, or protein to identify regions of similarity that may be a consequence of functional, structural, or evolutionary relationships between the sequences.[1][2] Aligned sequences of nucleotide or amino acid residues are typically represented as rows within a matrix. Gaps are inserted between the residues so that identical or similar characters are aligned in successive columns.
Sequence alignments are also used for non-biological sequences such as calculating the distance cost between strings in a natural language, or to display financial data.
A sequence alignment, produced by ClustalO, of mammalian histone proteins. Sequences are the amino acids for residues 120-180 of the proteins. Residues that are conserved across all sequences are highlighted in grey. Below the protein sequences is a key denoting conserved sequence (*), conservative mutations (:), semi-conservative mutations (.), and non-conservative mutations ( ).[3]
^Mount DM. (2004). Bioinformatics: Sequence and Genome Analysis (2nd ed.). Cold Spring Harbor Laboratory Press: Cold Spring Harbor, NY. ISBN 978-0-87969-608-5.
^Gagniuc, Paul A. (2021). Algorithms in bioinformatics: theory and implementation (1st ed.). Hoboken, NJ: John Wiley & Sons. pp. 1–528. ISBN 978-1-119-69800-5. OCLC 1240827446.{{cite book}}: CS1 maint: date and year (link)
^"Clustal FAQ #Symbols". Clustal. Archived from the original on 24 October 2016. Retrieved 8 December 2014.
and 23 Related for: Sequence alignment information
In bioinformatics, a sequencealignment is a way of arranging the sequences of DNA, RNA, or protein to identify regions of similarity that may be a consequence...
Multiple sequencealignment (MSA) is the process or the result of sequencealignment of three or more biological sequences, generally protein, DNA, or...
of sequencealignment software is a compilation of software tools and web portals used in pairwise sequencealignment and multiple sequencealignment. See...
another. In sequencealignments of proteins, the degree of similarity between amino acids occupying a particular position in the sequence can be interpreted...
areas of the life sciences. This includes visualization of sequences, genomes, alignments, phylogenies, macromolecular structures, systems biology, microscopy...
acid or protein sequence as input, or use statistical models generated from multiple sequencealignments of known related sequences. Statistical models...
unrecognizable. The first sequence assemblers began to appear in the late 1980s and early 1990s as variants of simpler sequencealignment programs to piece together...
techniques that provide the sequence comparisons (sequencealignment) and analyze the alignment product to understand its biology. Sequence analysis in molecular...
Alignment Map (BAM) is the comprehensive raw data of genome sequencing; it consists of the lossless, compressed binary representation of the Sequence...
protein molecules Sequencealignment, in bioinformatics, arranging the sequences of DNA, RNA, or protein to identify similarities Alignment program, software...
Clustal is a computer program used for multiple sequencealignment in bioinformatics. The software (and algorithms) have gone through several iterations...
acid sequences converge on a common tertiary structure. Structural alignments can compare two sequences or multiple sequences. Because these alignments rely...
matrix used for sequencealignment of proteins. BLOSUM matrices are used to score alignments between evolutionarily divergent protein sequences. They are based...
method of scoring alignments of two or more sequences. When aligning sequences, introducing gaps in the sequences can allow an alignment algorithm to match...
This page is a subsection of the list of sequencealignment software. Multiple alignment visualization tools typically serve four purposes: Aid general...
at each position in a sequencealignment. It represents the results of multiple sequencealignments in which related sequences are compared to each other...
multiple alignment using fast Fourier transform) is a program used to create multiple sequencealignments of amino acid or nucleotide sequences. Published...
of the query sequence, and on the production of an alignment that maps residues in the query sequence to residues in the template sequence. It has been...
the pairwise distances between two sequences in sequence space. They are used in structural and sequential alignment, and for the determination of protein...
homologous to the sequences that were used to construct the profile-HMM. Profile-HMMs are constructed from a multiple sequencealignment in the HMMER package...
BLAST sequencealignment program and a widely respected figure in bioinformatics. NCBI had responsibility for making available the GenBank DNA sequence database...
changes from a common ancestral sequence. Alignments of multiple sequences are used to indicate which regions of each sequence are homologous. The term "percent...
with and post-processing short DNA sequence read alignments in the SAM (SequenceAlignment/Map), BAM (Binary Alignment/Map) and CRAM formats, written by...
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