IRF8 information

IRF8
Identifiers
Aliases	IRF8, H-ICSBP, ICSBP, ICSBP1, IMD32A, IMD32B, IRF-8, interferon regulatory factor 8
External IDs	OMIM: 601565 MGI: 96395 HomoloGene: 1629 GeneCards: IRF8
Gene location (Human)
Chr.	Chromosome 16 (human)
End	85,922,606 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	121,483,433 bp
RNA expression pattern
	Top expressed in
	monocyte; ; lymph node; ; spleen; ; secondary oocyte; ; appendix; ; blood; ; bone marrow; ; rectum; ; trabecular bone; ; duodenum;
	Top expressed in
	spleen; ; bone marrow; ; submandibular gland; ; crypt of lieberkuhn of small intestine; ; jejunum; ; subcutaneous adipose tissue; ; blood; ; Paneth cell; ; duodenum; ; thymus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; DNA-binding transcription factor activity; protein binding; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytosol; nucleoplasm; nucleus; cytoplasm;
Biological process	myeloid cell differentiation; regulation of transcription, DNA-templated; response to bacterium; positive regulation of interleukin-12 production; interferon-gamma-mediated signaling pathway; positive regulation of interferon-gamma production; positive regulation of transcription initiation from RNA polymerase II promoter; transcription, DNA-templated; positive regulation of transcription, DNA-templated; defense response to bacterium; type I interferon signaling pathway; immune response; phagocytosis; cellular response to lipopolysaccharide; defense response to protozoan; negative regulation of transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; cellular response to interferon-gamma; autophagy; immune system process;
	Sources:Amigo / QuickGO
Orthologs
	3394
	15900
	ENSG00000140968
	ENSMUSG00000041515
	Q02556
	P23611
	NM_002163; NM_001363907; NM_001363908
	NM_001301811; NM_008320
	NP_002154; NP_001350836; NP_001350837
	NP_001288740; NP_032346
	Wikidata
View/Edit Human	View/Edit Mouse

Interferon regulatory factor 8 (IRF8) also known as interferon consensus sequence-binding protein (ICSBP), is a protein that in humans is encoded by the IRF8 gene.^[5]^[6]^[7] IRF8 is a transcription factor that plays critical roles in the regulation of lineage commitment and in myeloid cell maturation including the decision for a common myeloid progenitor (CMP) to differentiate into a monocyte precursor cell.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000140968 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000041515 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: IRF8 interferon regulatory factor 8".
^ Weisz A, Marx P, Sharf R, Appella E, Driggers PH, Ozato K, Levi BZ (December 1992). "Human interferon consensus sequence binding protein is a negative regulator of enhancer elements common to interferon-inducible genes". J. Biol. Chem. 267 (35): 25589–96. doi:10.1016/S0021-9258(19)74081-2. PMID 1460054.^{[permanent dead link]}
^ Nehyba J, Hrdlicková R, Burnside J, Bose HR (June 2002). "A novel interferon regulatory factor (IRF), IRF-10, has a unique role in immune defense and is induced by the v-Rel oncoprotein". Mol. Cell. Biol. 22 (11): 3942–57. doi:10.1128/MCB.22.11.3942-3957.2002. PMC 133824. PMID 11997525.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000140968 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000041515 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: IRF8 interferon regulatory factor 8".

[pmid1460054-6] Weisz A, Marx P, Sharf R, Appella E, Driggers PH, Ozato K, Levi BZ (December 1992). "Human interferon consensus sequence binding protein is a negative regulator of enhancer elements common to interferon-inducible genes". J. Biol. Chem. 267 (35): 25589–96. doi:10.1016/S0021-9258(19)74081-2. PMID 1460054.^{[permanent dead link]}

[pmid11997525-7] Nehyba J, Hrdlicková R, Burnside J, Bose HR (June 2002). "A novel interferon regulatory factor (IRF), IRF-10, has a unique role in immune defense and is induced by the v-Rel oncoprotein". Mol. Cell. Biol. 22 (11): 3942–57. doi:10.1128/MCB.22.11.3942-3957.2002. PMC 133824. PMID 11997525.

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