Cellular Inhibitor of Apoptosis Protein 1 information
Mammalian protein found in Homo sapiens
cIAP1 (also named BIRC2) is the abbreviation for a human protein, cellular inhibitor of apoptosis protein-1. It belongs to the IAP family of proteins and therefore contains at least one BIR (baculoviral IAP repeat) domain.[1]
cIAP1 is a multi-functional protein which can be found in the cytoplasm of cells and in the nucleus of tumor cells. Its function in this particular case is yet to be understood. However, it is well known that this protein has a big influence in the growth of diverse cancers. cIAP1 is involved in the development process of osteosarcoma[2] and gastric cancer[3] among others.[4][5]
cIAP1
Name
Cellular inhibitor of apoptosis protein 1
Abbreviation
cIAP1
Protein family
Inhibitor of apoptosis proteins
Number of amino acids
618
Molecular weight
69,9 kDa
Human chromosome location
11
^Eckelman, B. P.; Drag, M.; Snipas, S. J.; Salvesen, G. S. (2008-02-01). "The mechanism of peptide-binding specificity of IAP BIR domains". Cell Death & Differentiation. 15 (5): 920–928. doi:10.1038/cdd.2008.6. ISSN 1350-9047. PMID 18239672.
^Ma, Ou; Cai, Wei-Wen; Zender, Lars; et al. (2009). "MMP13, Birc2 (cIAP1) and Birc3 (cIAP2), Amplified on Chromosome 9A1, Collaborate with p53 Deficiency in Mouse Osteosarcoma Progression". Cancer Res. 69 (6): 2559–67. doi:10.1158/0008-5472.CAN-08-2929. PMC 2663905. PMID 19276372.
^Park YM, Hong SW, Moon JH, Shin JS, Lee HR, Ha SH, Lee DH, Kim JH, Kim SM, Kim JE, Kim KP, Hong YS, Choi EK, Lee JS, Jin DH, Kim T, Jung SA (2015). "Cellular inhibitor of apoptosis protein 1 (cIAP1) stability contributes to YM155 resistance in human gastric cancer cells". J Biol Chem. 290 (16): 9974–85. doi:10.1074/jbc.M114.600874. PMC 4400372. PMID 25635055.
^Wang H, Zhang B, Chen Y, Zhang Y, Sun X, Xiao G, Nan K, Ren H, Qin S, Yang C (2016). "LCL161 increases paclitaxel-induced apoptosis by degrading cIAP1 and cIAP2 in NSCLC". J Exp Clin Cancer Res. 35 (1): 158. doi:10.1186/s13046-016-0435-7. PMC 5062899. PMID 27737687.
^Jean Berthelet; Arthur Marivin; Simon Gemble; Valérie Edmond; Stéphanie Plenchette; Brice Lagrange; Arlette Hammann; Alban Dupoux; Laurent Delva; Béatrice Eymin; Eric Solary; Laurence Dubrez; Jessy Cartier (2011). "Cellular Inhibitor of Apoptosis Protein-1 (cIAP1) Can Regulate E2F1 Transcription Factor-mediated Control of Cyclin Transcription". J Biol Chem. 286 (30): 26406–17. doi:10.1074/jbc.M110.191239. PMC 3143604. PMID 21653699.
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