proteasome-mediated ubiquitin-dependent protein catabolic process
negative regulation of cell population proliferation
positive regulation of defense response to virus by host
apoptotic process
response to cytokine
cell fate commitment
negative regulation of translation in response to oxidative stress
regulation of transcription, DNA-templated
common-partner SMAD protein phosphorylation
branching involved in mammary gland duct morphogenesis
extrinsic apoptotic signaling pathway
positive regulation of fibroblast proliferation
positive regulation of apoptotic signaling pathway
endoplasmic reticulum calcium ion homeostasis
transcription, DNA-templated
PML body organization
negative regulation of cell growth
intrinsic apoptotic signaling pathway by p53 class mediator
innate immune response
viral process
response to gamma radiation
response to UV
regulation of calcium ion transport into cytosol
positive regulation of protein localization to chromosome, telomeric region
fibroblast migration
protein targeting
immune system process
protein stabilization
positive regulation of apoptotic process involved in mammary gland involution
circadian regulation of gene expression
regulation of MHC class I biosynthetic process
regulation of circadian rhythm
negative regulation of transcription, DNA-templated
maintenance of protein location in nucleus
cellular response to interleukin-4
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
response to hypoxia
regulation of double-strand break repair
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
retinoic acid receptor signaling pathway
negative regulation of angiogenesis
negative regulation of ubiquitin-dependent protein catabolic process
entrainment of circadian clock by photoperiod
negative regulation of mitotic cell cycle
positive regulation of MHC class I biosynthetic process
positive regulation of transcription by RNA polymerase II
regulation of signal transduction by p53 class mediator
cellular response to leukemia inhibitory factor
protein import into nucleus
protein-containing complex assembly
positive regulation of nucleic acid-templated transcription
protein sumoylation
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
5371
18854
Ensembl
ENSG00000140464
ENSMUSG00000036986
UniProt
P29590
Q60953
RefSeq (mRNA)
NM_033250 NM_002675 NM_033238 NM_033239 NM_033240
NM_033244 NM_033246 NM_033247 NM_033249
NM_008884 NM_178087 NM_001311088
RefSeq (protein)
NP_002666 NP_150241 NP_150242 NP_150243 NP_150247
NP_150249 NP_150250 NP_150252 NP_150253
NP_001298017 NP_032910 NP_835188
Location (UCSC)
Chr 15: 73.99 – 74.05 Mb
Chr 9: 58.13 – 58.16 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Promyelocytic leukemia protein (PML) (also known as MYL, RNF71, PP8675 or TRIM19[5]) is the protein product of the PML gene. PML protein is a tumor suppressor protein required for the assembly of a number of nuclear structures, called PML-nuclear bodies, which form amongst the chromatin[5] of the cell nucleus. These nuclear bodies are present in mammalian nuclei, at about 1 to 30 per cell nucleus.[5] PML-NBs are known to have a number of regulatory cellular functions, including involvement in programmed cell death, genome stability, antiviral effects and controlling cell division.[5][6] PML mutation or loss, and the subsequent dysregulation of these processes, has been implicated in a variety of cancers.[5]
^ abcGRCh38: Ensembl release 89: ENSG00000140464 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000036986 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Sahin U, Lallemand-Breitenbach V, de Thé H (November 2014). "PML nuclear bodies: regulation, function and therapeutic perspectives". The Journal of Pathology. 234 (3): 289–91. doi:10.1002/path.4426. PMID 25138686. S2CID 34066050.
and 23 Related for: Promyelocytic leukemia protein information
Promyelocyticleukemiaprotein (PML) (also known as MYL, RNF71, PP8675 or TRIM19) is the protein product of the PML gene. PML protein is a tumor suppressor...
Acute promyelocyticleukemia (APML, APL) is a subtype of acute myeloid leukemia (AML), a cancer of the white blood cells. In APL, there is an abnormal...
forms of acute myeloid leukemia with recurrent genetic abnormalities: t(8;21), inv(16) or t(16;16), and acute promyelocyticleukemia with PML-RARA, in which...
cells. Nuclear bodies include Cajal bodies, the nucleolus, and promyelocyticleukemiaprotein (PML) nuclear bodies (also called PML oncogenic dots). Nuclear...
"Establishment of papillomavirus infection is enhanced by promyelocyticleukemiaprotein (PML) expression". Proceedings of the National Academy of Sciences...
which promotes transcription of small nuclear RNA (snRNA). Promyelocyticleukemiaprotein (PML-nuclear bodies) are spherical bodies found scattered throughout...
leukoencephalopathy, rare and usually fatal disorder Promyelocyticleukemiaprotein, tumor suppressor protein Programmable Macro Language, for Aveva industrial...
RA, Borden KL (Nov 1999). "The promyelocyticleukemiaprotein PML interacts with the proline-rich homeodomain protein PRH: a RING may link hematopoiesis...
treatment of acne and acute promyelocyticleukemia. For acne, it is applied to the skin as a cream, gel or ointment. For leukemia, it is taken by mouth for...
of numerical mathematics Cyto-Plasmic Promyelocytic Leukaemia (cPML), a form of the promyelocyticleukemiaprotein Central Pennsylvania Multiple Listing...
transcription factor E2F1 and the promyelocyticleukemiaprotein (PML) involved in apoptosis (programmed cell death). The CHK2 protein plays a critical role in...
PMID 10903152. Lin DY, Lai MZ, Ann DK, Shih HM (May 2003). "Promyelocyticleukemiaprotein (PML) functions as a glucocorticoid receptor co-activator by...
"Potentiation of GATA-2 activity through interactions with the promyelocyticleukemiaprotein (PML) and the t(15;17)-generated PML-retinoic acid receptor...
dots or promyelocyticleukemia (PML) nuclear bodies, and alters the expression of host and viral genes in combination with a neuron specific protein. At later...
PLA2G4D: encoding protein Phospholipase A2 group IVD PLA2G4E: encoding protein Phospholipase A2 group IVE PML: promyelocyticleukemiaprotein (involved in...
2002). "Interactions of STAT5b-RARalpha, a novel acute promyelocyticleukemia fusion protein, with retinoic acid receptor and STAT3 signaling pathways"...
PMID 10816420. Vallian S, Chin KV, Chang KS (December 1998). "The promyelocyticleukemiaprotein interacts with Sp1 and inhibits its transactivation of the epidermal...