CCL17 information

CCL17
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	1NR2, 1NR4
Identifiers
Aliases	CCL17, A-152E5.3, ABCD-2, SCYA17, TARC, C-C motif chemokine ligand 17
External IDs	OMIM: 601520 MGI: 1329039 HomoloGene: 2246 GeneCards: CCL17
Gene location (Human)
Chr.	Chromosome 16 (human)
End	57,416,063 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	95,538,664 bp
RNA expression pattern
	Top expressed in
	appendix; ; lymph node; ; upper lobe of left lung; ; gallbladder; ; minor salivary glands; ; rectum; ; bronchial epithelial cell; ; skin of abdomen; ; right lung; ; thymus;
	Top expressed in
	morula; ; facial motor nucleus; ; lip; ; superior frontal gyrus; ; thymus; ; Sertoli cell; ; visual cortex; ; right lung lobe; ; jejunum; ; spinal cord;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	cytokine activity; CCR chemokine receptor binding; signaling receptor binding; chemokine activity; CCR4 chemokine receptor binding; protein binding;
Cellular component	extracellular region; extracellular space;
Biological process	G protein-coupled receptor signaling pathway; negative regulation of myoblast differentiation; monocyte chemotaxis; chemokine-mediated signaling pathway; cellular response to tumor necrosis factor; cell-cell signaling; neutrophil chemotaxis; multicellular organism development; chemotaxis; positive regulation of GTPase activity; cellular response to interleukin-1; immune response; positive regulation of ERK1 and ERK2 cascade; cellular response to interferon-gamma; lymphocyte chemotaxis; inflammatory response; antimicrobial humoral immune response mediated by antimicrobial peptide; regulation of signaling receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	6361
	20295
	ENSG00000102970
	ENSMUSG00000031780
	Q92583
	n/a
	NM_002987
	NM_011332
	NP_002978
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

CCL17 is a powerful chemokine produced in the thymus and by antigen-presenting cells like dendritic cells, macrophages, and monocytes.^[5] CCL17 plays a complex role in cancer. It attracts T-regulatory cells allowing for some cancers to evade an immune response.^[6] However, in other cancers, such as melanoma, an increase in CCL17 is linked to an improved outcome.^[6] CCL17 has also been linked to autoimmune and allergic diseases.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000102970 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031780 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lacy P (2017). "Eosinophil Cytokines in Allergy". Cytokine Effector Functions in Tissues. Elsevier. pp. 173–218. doi:10.1016/b978-0-12-804214-4.00011-7. ISBN 978-0-12-804214-4.
^ ^a ^b Cite error: The named reference Korbecki_2020 was invoked but never defined (see the help page).
^ Cite error: The named reference Ness_2006 was invoked but never defined (see the help page).

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000102970 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031780 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Lacy_2017-5] Lacy P (2017). "Eosinophil Cytokines in Allergy". Cytokine Effector Functions in Tissues. Elsevier. pp. 173–218. doi:10.1016/b978-0-12-804214-4.00011-7. ISBN 978-0-12-804214-4.

[Korbecki_2020-6] Cite error: The named reference Korbecki_2020 was invoked but never defined (see the help page).

[Ness_2006-7] Cite error: The named reference Ness_2006 was invoked but never defined (see the help page).

CCL17 information

and 28 Related for: CCL17 information

CCL17

Cholinergic urticaria

Phospholipid

Chemokine

CCR4

Tumor necrosis factor

Cytokine

TARC

Haematopoiesis

CCL22

Interleukin 6

Interleukin 23

Interferon

Interleukin 17

Interleukin 12

Ubiquitin

List of human clusters of differentiation

Inflammatory cytokine

Tumor necrosis factor superfamily

Interleukin 23 subunit alpha

Interleukin 1 beta

Interleukin

CXCR4

Interleukin 5

RANKL

Fas ligand

Leukemia inhibitory factor

Interleukin 40