Bisoprolol, sold under the brand name Zebeta among others, is a beta blocker which is selective for the beta-1 receptor[7] and used for cardiovascular diseases,[7] including tachyarrhythmias, high blood pressure, angina, and heart failure.[7][8] It is taken by mouth.[7]
Common side effects include headache, feeling tired, diarrhea, and swelling in the legs.[7] More severe side effects include worsening asthma, blocking the ability to recognize low blood sugar, and worsening heart failure.[9] There are concerns that use during pregnancy may be harmful to the baby.[10]
Bisoprolol was patented in 1976 and approved for medical use in 1986.[11] It was approved for medical use in the United States in 1992.[7]
Bisoprolol is on the World Health Organization's List of Essential Medicines[12] and is available as a generic medication.[7][13] In 2020, it was the 267th most commonly prescribed medication in the United States, with more than 1million prescriptions.[14][15]
^"Monocor Product information". Health Canada. 31 July 2009. Retrieved 19 April 2024.
^"Zebeta (Bisoprolol Fumarate) Tablets". DailyMed. Retrieved 19 April 2024.
^"Bisoprolol fumarate tablet, film coated". DailyMed. 6 March 2024. Archived from the original on 19 April 2024. Retrieved 19 April 2024.
^Bühring KU, Sailer H, Faro HP, Leopold G, Pabst J, Garbe A (1986). "Pharmacokinetics and metabolism of bisoprolol-14C in three animal species and in humans". Journal of Cardiovascular Pharmacology. 8 (Suppl 11): S21–S28. doi:10.1097/00005344-198511001-00004. PMID 2439794. S2CID 38147937.
^Leopold G (1986). "Balanced pharmacokinetics and metabolism of bisoprolol". Journal of Cardiovascular Pharmacology. 8 (Suppl 11): S16–S20. doi:10.1097/00005344-198511001-00003. PMID 2439789. S2CID 25731558.
^Horikiri Y, Suzuki T, Mizobe M (March 1998). "Pharmacokinetics and metabolism of bisoprolol enantiomers in humans". Journal of Pharmaceutical Sciences. 87 (3): 289–294. doi:10.1021/js970316d. PMID 9523980.
^ abcdefg"Bisoprolol Fumarate". The American Society of Health-System Pharmacists. Archived from the original on 21 December 2016. Retrieved 8 December 2016.
^"Bisoprolol 2.5mg/5mg/10mg film coated tablet - Summary of Product Characteristics (SPC) - (eMC)". medicines.org.uk. 18 February 2014. Archived from the original on 20 December 2016. Retrieved 14 December 2016.
^"Bisoprolol - FDA prescribing information, side effects and uses". drugs.com. Archived from the original on 21 December 2016. Retrieved 14 December 2016.
^"Bisoprolol (Zebeta) Use During Pregnancy". drugs.com. Archived from the original on 21 December 2016. Retrieved 14 December 2016.
^Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 461. ISBN 9783527607495. Archived from the original on 2017-09-08.
^World Health Organization (2023). The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023). Geneva: World Health Organization. hdl:10665/371090. WHO/MHP/HPS/EML/2023.02.
^"Drugs@FDA: FDA Approved Drug Products". Archived from the original on 2015-02-25. Retrieved 2013-11-13.
^"The Top 300 of 2020". ClinCalc. Archived from the original on 12 February 2021. Retrieved 7 October 2022.
^"Bisoprolol - Drug Usage Statistics". ClinCalc. Archived from the original on 28 September 2022. Retrieved 7 October 2022.
Bisoprolol, sold under the brand name Zebeta among others, is a beta blocker which is selective for the beta-1 receptor and used for cardiovascular diseases...
Plus (with candesartan), etc. Beta blockers – e.g. Ziac or Lodoz (with bisoprolol), Nebilet Plus or Nebilet HCT (with nebivolol), Dutoprol or Lopressor...
late 1990s showed their efficacy at reducing morbidity and mortality. Bisoprolol, carvedilol, and sustained-release metoprolol are specifically indicated...
and bisoprolol C09BX03 Ramipril, amlodipine and hydrochlorothiazide C09BX04 Perindopril, bisoprolol and amlodipine C09BX05 Ramipril and bisoprolol C09BX06...
diuretic. Beta-blockers licensed to treat heart failure in the UK include bisoprolol, carvedilol, and nebivolol. Hydralazine is used to treat severe hypertension...
β-blockers tested, being approximately 3.5 times more β1-selective than bisoprolol. However, the drug's receptor selectivity in humans is more complex and...
Phenytoin Type Ic Encainide Flecainide Propafenone Type II (beta blockers) Bisoprolol Carvedilol Metoprolol Propranolol Type III (potassium channel blockers)...
improvement in patients with orthostatic intolerance after treatment with bisoprolol and fludrocortisone". Clinical Autonomic Research. 10 (5): 293–299. doi:10...
heart failure in the short term, certain beta blockers (e.g. carvedilol, bisoprolol and metoprolol) have been believed to reduce long-term morbidity and mortality...
in animal models. Newer, more cardio-selective beta blockers (such as bisoprolol, nebivolol, carvedilol, or metoprolol) are now used preferentially in...
pp. 18–40. doi:10.1007/978-3-0348-6809-9_3. ISBN 978-3-0348-6796-2. "Bisoprolol". www.drugbank.ca. "Cocaine". www.drugbank.ca. Archived from the original...
improvement in patients with orthostatic intolerance after treatment with bisoprolol and fludrocortisone". Clinical Autonomic Research. 10 (5): 293–299. doi:10...
commonly used, such as the beta-blockers carvedilol, metoprolol, and bisoprolol, and the Potassium-Channel-Blockers amiodarone, dronedarone, bretylium...
Cardiovascular diseases. Some products from Merck include Metformin, Bisoprolol, Levothyroxine and Digitoxin. Merck's clinical research strategy consists...
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