Prazosin, sold under the brand name Minipress among others, is a medication used to treat high blood pressure, symptoms of an enlarged prostate, and nightmares related to post-traumatic stress disorder (PTSD).[6] It is an α1 blocker.[6] It is a less preferred treatment of high blood pressure.[6] Other uses may include heart failure and Raynaud syndrome.[7] It is taken by mouth.[6]
Common side effects include dizziness, sleepiness, nausea, and heart palpitations.[6] Serious side effects may include low blood pressure with standing and depression.[6][7] Prazosin is a non-selective inverse agonist of the α1-adrenergic receptors.[6] It works to decrease blood pressure by dilating blood vessels and helps with an enlarged prostate by relaxing the outflow of the bladder.[6] How it works in PTSD is not entirely clear.[6]
Prazosin was patented in 1965 and came into medical use in 1974.[8] It is available as a generic medication.[6] In 2021, it was the 183rd most commonly prescribed medication in the United States, with more than 2million prescriptions.[9][10]
^"Prazosin (Minipress) Use During Pregnancy". Drugs.com. 26 November 2019. Retrieved 30 January 2020.
^"Hypovase Tablets 0.5mg - Summary of Product Characteristics (SmPC)". (emc). 26 April 2021. Retrieved 5 February 2023.
^"Minipress- prazosin hydrochloride capsule". DailyMed. 19 July 2021. Retrieved 5 February 2023.
^ abc"Prazosin". drugs.com. Retrieved 15 March 2020.
^Packer M, Meller J, Gorlin R, Herman MV (March 1979). "Hemodynamic and clinical tachyphylaxis to prazosin-mediated afterload reduction in severe chronic congestive heart failure". Circulation. 59 (3): 531–539. doi:10.1161/01.cir.59.3.531. PMID 761333.
^ abcdefghij"Prazosin Hydrochloride Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 18 March 2019.
^ abBritish national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 766. ISBN 9780857113382.
^Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 455. ISBN 9783527607495.
^"The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.
^"Prazosin - Drug Usage Statistics". ClinCalc. Retrieved 14 January 2024.
Prazosin, sold under the brand name Minipress among others, is a medication used to treat high blood pressure, symptoms of an enlarged prostate, and nightmares...
nightmares. Prazosin is an α1-blocker that acts as an inverse agonist at α1-adrenergic receptors. Raskind and colleagues studied the efficacy of prazosin for...
Scorpion antivenom has little effect in clinical treatment but application of prazosin reduces the mortality rate to less than 4%. As in other scorpions, the...
prescribed aspirin. Sympatholytic agents, such as the alpha-adrenergic blocker prazosin, may provide temporary relief to secondary Raynaud's phenomenon. Angiotensin...
efficient is an alpha-blocker, Prazosin, which reduces tone during sleep by blocking noradrenergic receptors. Prazosin would significantly decrease the...
include propranolol, oxprenolol, and metoprolol. The alpha-1 antagonist prazosin could be effective for PTSD. The alpha-2 agonists clonidine and guanfacine...
January 2011). "Efficacy and safety of scorpion antivenom plus prazosin compared with prazosin alone for venomous scorpion (Mesobuthus tamulus) sting: randomised...
of some pharmaceutical drugs including amiquinsin, hoquizil, piquizil, prazosin, quinazoline, tiapamil, toborinone, verazide, and vetrabutine.[citation...
clonidine (a central α2-agonist), diltiazem (a calcium channel blocker), and prazosin (an α1-blocker) on pulse pressure and found that, after one year of treatment...
Louis A. Faillace, MD, Department of Psychiatry and Behavioral Sciences. Prazosin, an alpha-adrenoceptor antagonist, is often prescribed, particularly for...
and the degree to which exposure therapy is included in the protocol". Prazosin (alpha-1 blocker) appears useful in decreasing the number of nightmares...
and/or anti-inflammatory medication together with anti-spasm drugs such as prazosin. The key difference between the two types of episodes will be that a blocked...
effective medication to help alleviate nightmares associated with PTSD is Prazosin. International Society for Neurochemistry List of neurochemists Molecular...
include: captopril, labetalol, amlodipine, felodipine, isradipine, and prazosin. Sublingual nifedipine is not recommended in hypertensive urgencies. This...
monitored carefully while taking tamsulosin. Alpha blockers, including prazosin, terazosin, doxazosin, or tamsulosin, do not appear to affect all-cause...
treat seizures. Melatonin – a hypnotic used to treat insomnia Minipress (prazosin) – atypical psychotropic used to treat PTSD Neurontin (gabapentin) – an...
found to be competitively antagonized by prazosin (a standard α1 antagonist) and ketanserin, with prazosin being the more potent antagonist (pA2 = 9...
the normal blood pressure. Antagonists of alpha-1 receptors (doxazosin, prazosin) cause vasodilation (a decrease in vascular smooth muscle tone with increase...
may be effective in reducing attacks. Prophylactic use of nifedipine, prazosin, and terazosin has also been reported to prevent attacks. Topical analgesics...
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