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Barbital information


Barbital
Clinical data
Trade namesVeronal, Medinal
AHFS/Drugs.comInternational Drug Names
MedlinePlusa682221
Routes of
administration
Oral
ATC code
  • N05CA04 (WHO)
Legal status
Legal status
  • BR: Class B1 (Psychoactive drugs)[1]
  • CA: Schedule IV
  • DE: Anlage III (Special prescription form required)
  • US: Schedule IV
Pharmacokinetic data
Elimination half-life30.3 (± 3.2) hours
Identifiers
IUPAC name
  • 5,5-diethylpyrimidine-2,4,6(1H,3H,5H)-trione
CAS Number
  • 57-44-3 checkY
PubChem CID
  • 2294
DrugBank
  • DB01483 checkY
ChemSpider
  • 2206 checkY
UNII
  • 5WZ53ENE2P
KEGG
  • D01740 checkY
ChEBI
  • CHEBI:31252 checkY
ChEMBL
  • ChEMBL444 checkY
CompTox Dashboard (EPA)
  • DTXSID5022643 Edit this at Wikidata
ECHA InfoCard100.000.301 Edit this at Wikidata
Chemical and physical data
FormulaC8H12N2O3
Molar mass184.195 g·mol−1
3D model (JSmol)
  • Interactive image
SMILES
  • O=C1NC(=O)NC(=O)C1(CC)CC
InChI
  • InChI=1S/C8H12N2O3/c1-3-8(4-2)5(11)9-7(13)10-6(8)12/h3-4H2,1-2H3,(H2,9,10,11,12,13) checkY
  • Key:FTOAOBMCPZCFFF-UHFFFAOYSA-N checkY
  (verify)

Barbital (or barbitone), marketed under the brand names Veronal for the pure acid and Medinal for the sodium salt, was the first commercially available barbiturate. It was used as a sleeping aid (hypnotic) from 1903 until the mid-1950s. The chemical names for barbital are diethylmalonyl urea or diethylbarbituric acid; hence, the sodium salt (known as medinal, a genericised trademark in the United Kingdom) is known also as sodium diethylbarbiturate.

  1. ^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.

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Barbital

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Barbital (or barbitone), marketed under the brand names Veronal for the pure acid and Medinal for the sodium salt, was the first commercially available...

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Barbiturate

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interactions [1] calculated with CrystalExplorer Program. Sodium barbital and barbital have also been used as pH buffers for biological research, e.g....

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Joseph von Mering

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observations that barbital (then known as diethyl-barbituric acid) has sedative properties in humans. In 1904, he helped to launch barbital under the brand...

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Thiobarbital

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analogue of barbital. It is of note that although the drug can be prepared by the above route (cf e.g. thialbarbital), reaction of barbital with phosphorus...

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Amobarbital

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than phenobarbital and barbital (in descending order). (Secobarbital > pentobarbital > amobarbital > phenobarbital > barbital) It has an LD50 in mice...

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Diethyl diethylmalonate

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is a derivative of diethyl malonate. It can be used in the synthesis of barbital. As being a diethyl malonate derivative, it can be combined with urea under...

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Schedule X

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Cosmetics Rules 1945: The list of Schedule X drugs: Amobarbital Amphetamine Barbital Cyclobarbital Dexamphetamine Ethchlorvynol Glutethimide Ketamine Meprobamate...

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Butabarbital

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discovered to have medical use in 1903, when a research at Bayer showed barbital to be an effective sedative for dogs. It was not until the mid 20th century...

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Phenobarbital

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relatively infrequent. The synthesis of a photoswitchable analog (DASA-barbital) and phenobarbital has been described for use as research compound in photopharmacology...

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Paul Epstein

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unable to find a new position abroad, and finally committed suicide by barbital overdose at Dornbusch, fearing Gestapo torture because he was a Jew. O'Connor...

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Cannabis

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Methylpentynol Trichloroethanol Barbiturates Allobarbital Amobarbital Aprobarbital Barbital Butabarbital Butobarbital Cyclobarbital Ethallobarbital Heptabarb Hexobarbital...

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Brazilian Controlled Drugs and Substances Act

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Alprazolam Amineptine Amobarbital Aprobarbital Armodafinil Barbexaclone Barbital Bromazepam Bromazolam Brotizolam Butabarbital Butalbital Camazepam Ketamine...

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Propofol

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Methylpentynol Trichloroethanol Barbiturates Allobarbital Amobarbital Aprobarbital Barbital Butabarbital Butobarbital Cyclobarbital Ethallobarbital Heptabarb Hexobarbital...

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Methaqualone

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Methylpentynol Trichloroethanol Barbiturates Allobarbital Amobarbital Aprobarbital Barbital Butabarbital Butobarbital Cyclobarbital Ethallobarbital Heptabarb Hexobarbital...

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Chloral hydrate

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susceptible to chloral hydrate addiction. After the 1904 invention of barbital, the first of the barbiturate family, chloral hydrate began to disappear...

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Barbituric acid

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use around the world at present. The first to be used in medicine was barbital (Veronal) starting in 1903, and the second, phenobarbital was first marketed...

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Butane

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Barbiturates (-)-DMBB Allobarbital Alphenal Amobarbital Aprobarbital Barbexaclone Barbital Benzobarbital Benzylbutylbarbiturate Brallobarbital Brophebarbital...

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Hexobarbital

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oldest sedative-hypnotic agents known, dating back from the introduction of barbital in the early 20th century. In Eastern Europe, hexobarbital (and other barbiturates)...

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Ryan Randall

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Death Unties, I Love a Luger, Spring, 8 Count, Yeah Rite, Emilie and Barbital, and the documentary films A Rock and a Hard Place and Data Mining the...

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CHEB

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action compared to other barbiturates. While other barbiturates such as Barbital are usually anticonvulsants, CHEB is a convulsant. CHEB's convulsant action...

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Alprazolam

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Barbiturates (-)-DMBB Allobarbital Alphenal Amobarbital Aprobarbital Barbexaclone Barbital Benzobarbital Benzylbutylbarbiturate Brallobarbital Brophebarbital...

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Xylazine

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Methylpentynol Trichloroethanol Barbiturates Allobarbital Amobarbital Aprobarbital Barbital Butabarbital Butobarbital Cyclobarbital Ethallobarbital Heptabarb Hexobarbital...

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Flunitrazepam

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Methylpentynol Trichloroethanol Barbiturates Allobarbital Amobarbital Aprobarbital Barbital Butabarbital Butobarbital Cyclobarbital Ethallobarbital Heptabarb Hexobarbital...

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Emil Fischer

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Josef von Mering, he helped to launch the first barbiturate sedative, barbital, in 1904. He next carried out pioneering work on proteins. By the introduction...

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Dimenhydrinate

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Methylpentynol Trichloroethanol Barbiturates Allobarbital Amobarbital Aprobarbital Barbital Butabarbital Butobarbital Cyclobarbital Ethallobarbital Heptabarb Hexobarbital...

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