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Amobarbital information


Amobarbital
Clinical data
AHFS/Drugs.comMicromedex Detailed Consumer Information
License data
  • US FDA: Amobarbital
Routes of
administration
Oral, IM, IV, Rectal
ATC code
  • N05CA02 (WHO)
Legal status
Legal status
  • BR: Class B1 (Psychoactive drugs)[1]
  • CA: Schedule IV
  • DE: Anlage III (Special prescription form required)
  • UK: Class B
  • US: Schedule II / Schedule III
  • UN: Psychotropic Schedule III
  • SE: Förteckning IV
Pharmacokinetic data
MetabolismHepatic
Elimination half-life8–42 hours
ExcretionRenal
Identifiers
IUPAC name
  • 5-ethyl-5-(3-methylbutyl)-1,3-diazinane-2,4,6-trione
CAS Number
  • 57-43-2 checkY 64-43-7 (sodium salt)
PubChem CID
  • 2164
DrugBank
  • DB01351 checkY
ChemSpider
  • 2079 checkY
UNII
  • GWH6IJ239E
KEGG
  • D00555 checkY
ChEBI
  • CHEBI:2673 checkY
ChEMBL
  • ChEMBL267894 checkY
CompTox Dashboard (EPA)
  • DTXSID9020081 Edit this at Wikidata
ECHA InfoCard100.000.300 Edit this at Wikidata
Chemical and physical data
FormulaC11H18N2O3
Molar mass226.276 g·mol−1
3D model (JSmol)
  • Interactive image
SMILES
  • O=C1NC(=O)NC(=O)C1(CCC(C)C)CC
InChI
  • InChI=1S/C11H18N2O3/c1-4-11(6-5-7(2)3)8(14)12-10(16)13-9(11)15/h7H,4-6H2,1-3H3,(H2,12,13,14,15,16) checkY
  • Key:VIROVYVQCGLCII-UHFFFAOYSA-N checkY
  (verify)

Amobarbital (formerly known as amylobarbitone or sodium amytal as the soluble sodium salt) is a drug that is a barbiturate derivative. It has sedative-hypnotic properties. It is a white crystalline powder with no odor and a slightly bitter taste. It was first synthesized in Germany in 1923. It is considered a short to intermediate acting barbiturate.[citation needed]

If amobarbital is taken for extended periods of time, physiological and psychological dependence can develop. Amobarbital withdrawal mimics delirium tremens and may be life-threatening. Amobarbital was manufactured by Eli Lilly and Company in the US under the brand name Amytal in bright blue bullet shaped capsules (known as Pulvules) or pink tablets (known as Diskets)[2] containing 50, 100, or 200 milligrams of the drug. The drug was also manufactured generically.

Amobarbital was widely misused, known as "Blue Heavens" on the street. Amytal, as well as Tuinal, a combination drug containing equal quantities of secobarbital and amobarbital, were both manufactured by Eli Lilly until the late-1990s. However, as the popularity of benzodiazepines increased, prescriptions for these medications became increasingly rare beginning in the mid to late-1980s.

  1. ^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
  2. ^ Winek, Charles L. (1965-02-01). "Dosage Form Names and Product Identification". American Journal of Health-System Pharmacy. 22 (2): 84. doi:10.1093/ajhp/22.2.82. ISSN 1079-2082.

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