ECH-associated protein 1 is a protein that in humans is encoded by the Keap1 gene. Keap1 has four discrete protein domains. The N-terminal Broad complex, Tramtrack...
like-ECH-associated protein 1 (KEAP1) and Cullin 3, which degrade NRF2 by ubiquitination. Cullin 3 ubiquitinates NRF2, while Keap1 is a substrate adaptor protein...
STRUCTURAL FEATURES THAT DETERMINE INDUCER POTENCY AND REACTIVITY WITH Keap1". The Journal of Biological Chemistry. 285 (44): 33747–33755. doi:10.1074/jbc...
parent and other cells as detailed elsewhere (see SUCNR1 and succinic acid). KEAP1 (i.e., Kelch-like ECH-associated protein 1) resides in the cytoplasm of...
(blue), ankyrin repeat domain of ANKRA2 (orange), kelch repeat domain of Keap1 (yellow) and HEAT repeat domain of a PP2A regulatory subunit R1a (magenta)...
(blue), ankyrin repeat domain of ANKRA2 (orange), kelch repeat domain of Keap1 (yellow) and HEAT repeat domain of a PP2A regulatory subunit R1a (magenta)...
stress-induced liver oxidative damage in broilers by activating the Nrf2-Keap1 signaling pathway". Ecotoxicology and Environmental Safety. 249: 114411...
has been described. Other genes involved affected by this mutation are Keap1, Nrf2 and HMOX1. The diagnosis is made either by testing of the fumarate...
phosphorylated, the binding affinity between protein complex p62 and the protein Keap1 is strengthened, which is linked to stress response. When serine 337 is...
genes, including TP53 (mutated in 46% of cases), EGFR (27%), KRAS (32%), KEAP1, STK11 and NF1. EGFR and KRAS mutations tend to appear in a mutually exclusive...
Antioxidant Response in Amyotrophic Lateral Sclerosis through Interactions with KEAP1". Molecular and Cellular Biology. 35 (14): 2385–2399. doi:10.1128/MCB.00087-15...
inactivations of p53 and RB (~40%), or inactivation of TP53 and STK11 or KEAP1 (~40%). The World Health Organization classification of lung tumors recognizes...
Tetsuro; Siow, Richard CM (2009). "Targeting the redox sensitive Nrf2–Keap1 defense pathway in cardiovascular disease: Protection afforded by dietary...
placebo-treated patients was similar. Bardoxolone methyl is an activator of the KEAP1-Nrf2 pathway in mice. Bardoxolone methyl also inhibits the pro-inflammatory...
normal conditions the Nrf2 is bound to Kelch-like ECH associated protein 1 (Keap1) in its inactive form. With the uptake of arsenic within cells and the subsequent...
stress-induced liver oxidative damage in broilers by activating the Nrf2-Keap1 signaling pathway". Ecotoxicology and Environmental Safety. 249: 114411...
malignancy. Certain cancers contain somatic mutations in NRF2(NFE2L2) or KEAP1 that cause constitutive activation of Nrf2 and promote cell proliferation...
effect of this inhibition is to inhibit and/or refers inflammation. KEAP1: cytosolic KEAP1 serves to promote the degradation of Nrf2 by proteasomes thereby...
(September 2008). "Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy". Proceedings of the National Academy...
of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survival. J...