This article is about the protein domain. For the compression algorithm, see Bzip2.
bZIP transcription factor
CREB (top) is a transcription factor capable of binding DNA via the bZIP domain (bottom) and regulating gene expression.
Identifiers
Symbol
bZIP_1
Pfam
PF00170
InterPro
IPR011616
PROSITE
PDOC00036
SCOP2
1ysa / SCOPe / SUPFAM
CDD
cd14686
Membranome
235
Available protein structures:
Pfam
structures / ECOD
PDB
RCSB PDB; PDBe; PDBj
PDBsum
structure summary
The Basic Leucine Zipper Domain (bZIP domain) is found in many DNA binding eukaryotic proteins. One part of the domain contains a region that mediates sequence specific DNA binding properties and the leucine zipper that is required to hold together (dimerize) two DNA binding regions. The DNA binding region comprises a number of basic amino acids such as arginine and lysine. Proteins containing this domain are transcription factors.[1][2]
^Ellenberger T (1994). "Getting a grip in DNA recognition: structures of the basic region leucine zipper, and the basic region helix-loop-helix DNA-binding domains". Curr. Opin. Struct. Biol. 4 (1): 12–21. doi:10.1016/S0959-440X(94)90054-X.
^Hurst HC (1995). "Transcription factors 1: bZIP proteins". Protein Profile. 2 (2): 101–68. PMID 7780801.
The Basic Leucine Zipper Domain (bZIPdomain) is found in many DNA binding eukaryotic proteins. One part of the domain contains a region that mediates...
a dimerization motif of the bZIP (Basic-region leucine zipper) class of eukaryotic transcription factors. The bZIPdomain is 60 to 80 amino acids in length...
melanogaster. Basic leucine zipper domain (bZIPdomain): found in many DNA-binding eukaryotic proteins. One part of the domain contains a region that mediates...
bZIP Maf is a domain found in Maf transcription factor proteins. It contains a leucine zipper (bZIP) domain, which mediates the transcription factor's...
(Neh) domains. The Neh1 domain is a CNC-bZIPdomain that allows Nrf2 to heterodimerize with small Maf proteins (MAFF, MAFG, MAFK). The Neh2 domain allows...
X-box binding protein 1 (XBP1) is a transcription factor containing a bZIPdomain. It was first identified by its ability to bind to the Xbox, a conserved...
to the family of basic leucine zipper (bZIP), and shows high homology with the ATF3 bZIPdomain. The bZIPdomain includes the amino acids from position...
Krüppel factor in Drosophila. It often appears as a metal-binding domain in multi-domain proteins. Proteins that contain zinc fingers (zinc finger proteins)...
regulation by regions outside of the bZIP domain, regulation of subnuclear localization of the bZIPdomains Fos and Jun by their different interacting...
of the popular Unix compressing tools gzip and bzip2. Just like gzip and bzip, xz and lzma can only compress single files (or data streams) as input. They...
The DNA binding of CREB is mediated via its basic leucine zipper domain (bZIPdomain) as depicted in the image. Evidence suggests the β-adrenoceptor (a...
factors that have well-conserved homeodomains. The Pou domain is a bipartite DNA binding domain found in these proteins. The acronym POU is derived from...
activation (ACT) domain and a basic zipper DNA-binding (bZip) domain with a HAT domain in-between. The last is TAFII250 which has a Kinase domain at the N-terminus...
sequence specific TF according to literature or domain structure – No motif [1] AC023509.3 ENSG00000267281 bZIP Known motif – from protein with 100% identical...
respiratory factor 1 (Nrf1). NFE2L1 is a cap ‘n’ collar, basic-leucine zipper (bZIP) transcription factor. Several isoforms of NFE2L1 have been described for...
activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic...
in adipose tissue. The C/EBPs follow a general basic-leucine zipper (bZIP) domain at the C-terminus and are able to form dimers with other C/EBPs or other...
up of 282 amino acids. ATF5 is a transcription factor that contains a bZipdomain. Activating transcription factor ATF5 has been shown to interact with...
for tissue specific transcription factors containing an N-terminal paired domain and usually a partial, or in the case of four family members (PAX3, PAX4...
gene. In 2001, Peters et al. published a paper showing that ATF-7, a Novel bZIP Protein, interacts with PTP4A1. This ATF-7 is actually ATF5 and not ATF7...
Global Information